MRI: Acquisition-Upgrade of a 400 MHz Nuclear Magnetic Resonance Spectrometer to Facilitate Faculty Research and Improve Student Research and Education

利用由化学研究仪器和设施(CRIF)计划共同资助的重大研究仪器计划颁发的这一奖项，威廉与玛丽学院的Christopher Abelt教授及其同事Deborah Bebout、Elizabeth Harbron、Robert Hinkle和Jonathan Scheer将升级一台400 MHz核磁共振光谱仪，配备新的控制台、探头和自动进样器。该建议旨在加强各级的研究和教育，特别是在下列领域：(A)对氧碳正离子的合成和机理研究中获得的草环产物进行立体化学分析；(B)生物活性多环天然产物的合成和生物合成研究；(C)研究荧光团和环糊精之间的主客体络合物；(D)与金属毒性有关的溶液动力学研究；(E)光致变色聚合物体系中的荧光调制；(F)寻找具有扩展遗传密码的治疗工具；核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是包括本科生和硕士学生在内的教学和研究的一个组成部分。这种使用最先进的核磁共振仪器进行的培训将增强毕业生进入竞争激烈的博士课程和在化工行业寻找工作的职业准备。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Christopher Abelt from College of William & Mary and colleagues Deborah Bebout, Elizabeth Harbron, Robert Hinkle and Jonathan Scheerer will upgrade a 400 MHz NMR spectrometer with a new console, probe and autosampler. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) stereochemical analyses of oxacyclic products obtained during synthetic and mechanistic studies of oxocarbenium ions; (b) synthetic, and biosynthetic studies of biologically active, polycyclic natural products; (c) examination of host-guest complexes between fluorophores and cyclodextrins; (d) studies of solution dynamics related to metal toxicities; (e) fluorescence modulation in photochromic polymer systems; (f) search for therapeutic tools with an expanded genetic code; and (g) examination of new catalysts for solar hydrogen generation.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research involving undergraduate and master students. Such training with state-of-the-art NMR instrumentation will enhance the professional readiness of graduates entering competitive doctoral programs and those seeking employment in the chemical industry.