MRI: Acquisition-Upgrade of a 400 MHz Nuclear Magnetic Resonance Spectrometer to Facilitate Faculty Research and Improve Student Research and Education

MRI：购置并升级 400 MHz 核磁共振波谱仪，以促进教师研究并改善学生研究和教育

• 批准号: 1337295
• 负责人: Christopher Abelt
• 金额: $ 18.13万
• 依托单位: College of William and Mary
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1337295&HistoricalAwards=false
• 关键词: MRI; Acquisition; Upgrade; 400; MHz

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor Christopher Abelt from College of William & Mary and colleagues Deborah Bebout, Elizabeth Harbron, Robert Hinkle and Jonathan Scheerer will upgrade a 400 MHz NMR spectrometer with a new console, probe and autosampler. The proposal is aimed at enhancing research and education at all levels, especially in areas such as (a) stereochemical analyses of oxacyclic products obtained during synthetic and mechanistic studies of oxocarbenium ions; (b) synthetic, and biosynthetic studies of biologically active, polycyclic natural products; (c) examination of host-guest complexes between fluorophores and cyclodextrins; (d) studies of solution dynamics related to metal toxicities; (e) fluorescence modulation in photochromic polymer systems; (f) search for therapeutic tools with an expanded genetic code; and (g) examination of new catalysts for solar hydrogen generation.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research involving undergraduate and master students. Such training with state-of-the-art NMR instrumentation will enhance the professional readiness of graduates entering competitive doctoral programs and those seeking employment in the chemical industry.

有了这个由化学研究仪器和设施（CRIF）计划共同资助的主要研究仪器计划的奖项，William玛丽学院的Christopher Abelt教授和同事Deborah Bebout，Elizabeth Harbron，Robert Hinkle和Jonathan Scheerer将升级400 MHz NMR光谱仪，配备新的控制台，探头和自动进样器。该提案旨在加强各级的研究和教育，特别是在以下领域：（a）对在氧碳正离子的合成和机理研究过程中获得的氧杂环产品进行立体化学分析;（B）对具有生物活性的多环天然产品进行合成和生物合成研究;（c）检查荧光团和环糊精之间的主客体复合物;（d）与金属毒性有关的溶液动力学研究;（e）光致变色聚合物系统中的荧光调制;（f）寻找具有扩展遗传密码的治疗工具;（g）研究太阳能制氢的新催化剂。光谱学是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将是教学的一个组成部分，以及涉及本科生和硕士研究生的研究。这种培训与国家的最先进的核磁共振仪器将提高毕业生进入竞争激烈的博士课程和那些寻求在化学工业就业的专业准备。