Conference: New Advances in Probing Cell-Extracellular Matrix Interactions; Berlin, Germany; October 21 - 22, 2016

会议：探测细胞-细胞外基质相互作用的新进展；

• 批准号: 1630448
• 负责人: Ovijit Chaudhuri
• 金额: $ 1.03万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2017-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1630448&HistoricalAwards=false
• 关键词: Conference; New; Advances; Probing; Cell

Many of the secrets to life lie outside the cell. The extracellular matrix (ECM), consisting of primarily proteins supports the cells within a tissue. While the ECM has long been viewed as a static "home" for cells, we are starting to understand how the stiffness of the extracellular matrix changes cell activities in ways that are similar to how dissolved signaling molecules control cell behavior. In other words, the ECM helps determine what the cell does during development of a baby, and during adulthood, wound healing, and cancer invasion. Support from this grant for the conference "New Advances in Probing Cell-Extracellular Matrix Interactions; Berlin, Germany; October 21 - 22, 2016" will enable young investigators to meet senior scientists and to understand technologies at the cutting edge of the field.Recent progress in cell mechanotransduction research has been facilitated by advances of experimental tools. Microtechnologies have enabled the design and fabrication of controlled physical microenvironments for the study and measurement of cell-ECM interactions. Advances in engineered biomaterials have allowed researchers to develop synthetic ECMs that mimic tissue microenvironments and investigate the impact of altered physicochemical properties on various cellular processes. Finally, advanced imaging and spectroscopy techniques have facilitated the visualization of the complex interaction between cells and ECM in vitro and in living tissues. This meeting will highlight the application of recent innovations in these technologies to probing cell-ECM interactions with an aim to inspire new combinatorial experiments from the interaction of these sub-disciplines.

生命的许多秘密都隐藏在细胞之外。细胞外基质(ECM)主要由蛋白质组成，支持组织内的细胞。虽然细胞外基质长期以来一直被视为细胞的静态“家”，但我们开始了解细胞外基质的僵硬如何改变细胞活动，其方式类似于溶解的信号分子如何控制细胞行为。换句话说，细胞外基质有助于确定细胞在婴儿发育期间、成年期间、伤口愈合和癌症侵袭期间的作用。这笔赠款支持了2016年10月21日至22日在德国柏林举行的“探测细胞-细胞外基质相互作用的新进展”会议，这将使年轻的研究人员能够会见资深科学家并了解该领域的前沿技术。实验工具的进步促进了细胞机械转导研究的最新进展。微技术使研究和测量细胞-细胞外基质相互作用的受控物理微环境的设计和制造成为可能。工程生物材料的进步使研究人员能够开发模拟组织微环境的合成ECM，并研究改变的物理化学性质对各种细胞过程的影响。最后，先进的成像和光谱技术有助于在体外和活组织中可视化细胞和细胞外基质之间的复杂相互作用。这次会议将突出这些技术的最新创新在探索细胞-细胞外基质相互作用方面的应用，目的是从这些子学科的相互作用中启发新的组合实验。