I-Corps: Noninvasive method for assessing cardiovascular stress arising from acute exposure to nanoparticles

I-Corps：评估急性暴露于纳米粒子引起的心血管应激的无创方法

• 批准号: 1637682
• 负责人: Joseph Starobin
• 金额: $ 4.95万
• 依托单位: University of North Carolina Greensboro
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1637682&HistoricalAwards=false
• 关键词: Corps; Noninvasive; method; assessing; cardiovascular

As modern technology has made the collection of vast amounts of data of all kinds extremely cheap and easy, new approaches to analyzing such information are required for this type of technology to be truly useful. In particular, the advent of affordable and portable electrocardiogram (ECG) measurement devices has enabled collection and storage of hours of detailed information about patients? personal cardiovascular system. However, the untrained individual's limited ability to interpret this raw information limits the revolutionary healthcare potential of such technology. Consequently, there is no decrease in required face-to-face visits with a physician, and many ethical questions arise regarding storage, transmission and responsibility of the doctor to monitor such information. In this project, this I-Corps team outlines a strategy for taking such technology to the next level of personalization by incorporating a novel metric for cardiovascular health into currently available portable ECG measurement devices.The ability to extract meaningful information from a large set of data is of paramount importance in the digital age. At its core, the proposed technology isolates the degrees of freedom within the cardiovascular system that govern a particular aspect of the heart's response to external stresses including pollutants. By enabling real-time measurement of the cardiac muscle physical ability to recover from a single contraction through the so-called "reserve of refractoriness" (RoR), the door to non-invasive assessment of exposure to arbitrary types of potential pollutants is opened. A remarkable feature of introduced metric is its lack of sensitivity to the inherent noise in low-resolution, single-lead ECG measurement devices. Such a stiffness makes the proposed refractoriness metric an ideal method for analyzing the cardiovascular system in a variety of practical contexts. Specifically, the proposed technology demonstrates how it may be rewarding for the medical industry, companies with concern for occupational or environmental hazards, as well as for the vast fitness industry.

由于现代技术使收集大量各种数据变得极其便宜和容易，因此需要新的方法来分析此类信息，以使此类技术真正有用。特别是，价格实惠的便携式心电图 (ECG) 测量设备的出现使得能够收集和存储数小时的患者详细信息？个人心血管系统。然而，未经训练的个人解释这些原始信息的能力有限，限制了此类技术的革命性医疗保健潜力。因此，与医生面对面就诊的次数并没有减少，并且出现了许多关于医生监控此类信息的存储、传输和责任的道德问题。在这个项目中，I-Corps 团队概述了一项策略，通过将一种新颖的心血管健康指标纳入当前可用的便携式心电图测量设备中，将此类技术提升到个性化的新水平。从大量数据中提取有意义的信息的能力在数字时代至关重要。其核心是，所提出的技术隔离了心血管系统内的自由度，这些自由度控制着心脏对包括污染物在内的外部压力的反应的特定方面。通过所谓的“不应储备”(RoR) 实时测量心肌从单次收缩中恢复的物理能力，打开了对任意类型的潜在污染物暴露进行非侵入性评估的大门。引入的指标的一个显着特点是它对低分辨率、单导联心电图测量设备中的固有噪声缺乏敏感性。这样的刚度使得所提出的不应度度量成为在各种实际情况下分析心血管系统的理想方法。具体来说，拟议的技术展示了它如何为医疗行业、关注职业或环境危害的公司以及广大的健身行业带来回报。