Phase II I/UCRC University of California-Davis: Center for Biophotonics Sensors and Systems

CBSS在生命科学和光子工程的交叉点上运作，专注于竞争前研究，为先进的方法提供支持技术，以检测、感知和识别分子、细胞和亚细胞水平的生物特性、条件或变化。这些创新将通过与CBSS成员的长期工业合作伙伴关系，解决疾病诊断、药物功效测试和监测、药物发现和食品和水安全等领域的解决方案。在第二阶段，研究工作将继续在波士顿大学（牵头机构）和加州大学戴维斯分校（大学所在地）开展，与我们校园内与中心相关的研究人员开展合作。年代的使命。该中心的研究有潜力通过开发生物传感方法并将其应用于行业成员定义的重要应用领域，从而促进知识的发展，从而满足市场的巨大需求。与此同时，行业参与将增强我们多样化科学家和工程师的教育经验。学生有机会直接参与技术转移过程，并与行业一起学习识别应用程序并定义最大需求领域，评估新技术和研究工具，并进行可应用于解决现实世界挑战和改善医疗保健结果的研究。随着CBSS的发展，该中心打算利用生命科学领域公司的趋势，通过合作研究和大学主导的创新来加速创新，特别是在生物光子传感领域。该中心对会员的价值是基于提供竞争前研究的能力，这些研究可以根据会员的产品组合长期计划进行调整。这种高优先级的研究和产品导向的研究通常是每个公司的重点，但总的来说，会员对中心的价值在于：-增加成员研究组合的广度和多样性。-致力于竞争前的技术，可以在未来带来一些好处。-研究有价值的替代方法，但成员公司既没有时间也没有资源去追求。这也有助于成员更好地定位他们现有的产品/技术方法。提供可能在公司领域之外的新兴研究领域的机会，从而增加一个成员？创新能力。在行业战略监督的指导下，这些研究项目将在理解细胞/宿主相互作用、新的生物标志物发现、护理点和互操作诊断、个性化癌症治疗以及许多其他将提高医疗质量的技术方面取得突破。该中心的研究与三个重叠的重点领域保持一致：生物成像、光学诊断和分析，每个重点领域都有系统、传感器和设备以及材料和生物学的组成部分。Analytics研究的目标是在成像和诊断工具中嵌入数据检索和计算处理能力，以开发对所收集的生物、遗传、行为和环境数据的理解，从而可以在个人层面上做出医疗保健决策。加州大学戴维斯分校将继续利用其科学专业知识、基础设施和研究能力来发展生物光子传感器和系统工具箱，并将这些新技术应用于更好、更快、更便宜的医疗保健。在第二阶段，我们计划从加州大学其他校区聘请教师，从而进一步扩大中心的研究能力和专业知识。

CBSS operates at the intersection of life sciences and photonics engineering and focuses on precompetitive research that provides the enabling technologies for advanced methods to detect, sense and identify biological properties, conditions or changes at the molecular, cellular and subcellular level. These innovations will address solutions in the areas of Disease Diagnosis, Drug Efficacy Testing & Monitoring, Drug Discovery, and Food & Water Safety through long-term industrial partnerships with the CBSS members. During Phase II, research efforts will continue at Boston University (lead institution) and UC Davis (university site) to develop collaborations with faculty across our campuses whose research is relevant to the Center?s mission. The Center's research has the potential to advance knowledge by developing biosensing methods and applying them to important application areas defined by industry members to be of great demand in the marketplace. At the same time, industry participation will enhance the educational experiences of our pipeline of diverse scientist and engineers. Students have an opportunity to directly participate in the technology transfer process and with industry learn to identify applications and define areas of greatest needs, evaluate new technologies and research tools, and pursue research that can be applied to solving real-world challenges and improving healthcare outcomes. As CBSS grows, the Center intends to capitalize on a trend by companies in the life sciences sector to accelerate innovation through collaborative research and university-led innovations, specifically in the area of biophotonic sensing. The Center's value to the membership is based on the ability to deliver pre-competitive research that can be adapted to align with a member's product portfolio long-term plans. This high priority research and product directed research typically remains the focus of each individual company, but collectively, the membership values the Center for:- Adding to the breadth and diversity of a member's research portfolio.- Working on pre-competitive technologies that could add some benefits in the future.- Working on alternative approaches that have merit but which a member company has neither the time nor the resources to pursue. This also helps a member better position their existing product/technology approaches. Providing exposure to emerging areas of research that may be outside the company's domain, thus adding to a member?s innovation capability.The research projects, guided by industry strategic oversight, will lead to breakthroughs in understanding cell/host interactions, new biomarker discovery, point-of-care and interoperation diagnostics, personalized cancer treatment, and many other technologies that will improve the quality of healthcare. The Center's research is aligned with three overlapping thrust areas: Bio-Imaging, Optical Diagnostics and Analytics, and each of these thrust areas has a component in Systems, Sensors & Devices, and Materials & Biology. The goal of the Analytics research is to embed data retrieval and computing processing power in imaging and diagnostic tools to develop an understanding of biological, genetic, behavioral and environmental data gathered so that healthcare decisions can be made down to the individual level. The UC Davis site will continue to leverage its scientific expertise, infrastructure and research capabilities to grow the toolbox of biophotonic sensors and systems and apply these new technologies towards better, faster, and more inexpensive healthcare. During Phase II, we plan to engage faculty from additional University of California campuses and thus further expand the Center/s research capabilities and expertise.