Phase II I/UCRC University of California-Davis: Center for Biophotonics Sensors and Systems

II 期 I/UCRC 加州大学戴维斯分校：生物光子传感器和系统中心

• 批准号: 1650588
• 负责人: James Chan
• 金额: $ 50万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1650588&HistoricalAwards=false
• 关键词: Phase; II; UCRC; University; California

CBSS operates at the intersection of life sciences and photonics engineering and focuses on precompetitive research that provides the enabling technologies for advanced methods to detect, sense and identify biological properties, conditions or changes at the molecular, cellular and subcellular level. These innovations will address solutions in the areas of Disease Diagnosis, Drug Efficacy Testing & Monitoring, Drug Discovery, and Food & Water Safety through long-term industrial partnerships with the CBSS members. During Phase II, research efforts will continue at Boston University (lead institution) and UC Davis (university site) to develop collaborations with faculty across our campuses whose research is relevant to the Center?s mission. The Center's research has the potential to advance knowledge by developing biosensing methods and applying them to important application areas defined by industry members to be of great demand in the marketplace. At the same time, industry participation will enhance the educational experiences of our pipeline of diverse scientist and engineers. Students have an opportunity to directly participate in the technology transfer process and with industry learn to identify applications and define areas of greatest needs, evaluate new technologies and research tools, and pursue research that can be applied to solving real-world challenges and improving healthcare outcomes. As CBSS grows, the Center intends to capitalize on a trend by companies in the life sciences sector to accelerate innovation through collaborative research and university-led innovations, specifically in the area of biophotonic sensing. The Center's value to the membership is based on the ability to deliver pre-competitive research that can be adapted to align with a member's product portfolio long-term plans. This high priority research and product directed research typically remains the focus of each individual company, but collectively, the membership values the Center for:- Adding to the breadth and diversity of a member's research portfolio.- Working on pre-competitive technologies that could add some benefits in the future.- Working on alternative approaches that have merit but which a member company has neither the time nor the resources to pursue. This also helps a member better position their existing product/technology approaches. Providing exposure to emerging areas of research that may be outside the company's domain, thus adding to a member?s innovation capability.The research projects, guided by industry strategic oversight, will lead to breakthroughs in understanding cell/host interactions, new biomarker discovery, point-of-care and interoperation diagnostics, personalized cancer treatment, and many other technologies that will improve the quality of healthcare. The Center's research is aligned with three overlapping thrust areas: Bio-Imaging, Optical Diagnostics and Analytics, and each of these thrust areas has a component in Systems, Sensors & Devices, and Materials & Biology. The goal of the Analytics research is to embed data retrieval and computing processing power in imaging and diagnostic tools to develop an understanding of biological, genetic, behavioral and environmental data gathered so that healthcare decisions can be made down to the individual level. The UC Davis site will continue to leverage its scientific expertise, infrastructure and research capabilities to grow the toolbox of biophotonic sensors and systems and apply these new technologies towards better, faster, and more inexpensive healthcare. During Phase II, we plan to engage faculty from additional University of California campuses and thus further expand the Center/s research capabilities and expertise.

CBSS在生命科学和光子学工程的交叉点上运作，专注于竞争前的研究，为先进的方法提供使能技术，以检测、感知和识别分子、细胞和亚细胞水平的生物特性、条件或变化。这些创新将通过与CBSS成员的长期工业伙伴关系，解决疾病诊断、药效测试和监测、药物发现和食品与水安全领域的解决方案。在第二阶段，波士顿大学(牵头机构)和加州大学戴维斯分校(大学网站)的研究工作将继续进行，以发展与我们校园内教师的合作，这些教师的研究与S中心的任务相关。该中心的研究有可能通过开发生物传感方法并将其应用于行业成员定义的市场需求巨大的重要应用领域来促进知识的发展。与此同时，业界的参与将增强我们培养不同科学家和工程师的教育经验。学生有机会直接参与技术转让过程，并与行业一起学习识别应用程序和定义最大需求的领域，评估新技术和研究工具，并从事可应用于解决现实世界挑战和改善医疗保健结果的研究。随着CBSS的发展，该中心打算利用生命科学领域的公司通过合作研究和大学主导的创新加速创新的趋势，特别是在生物光子学传感领域。该中心对会员的价值基于提供竞争前研究的能力，这些研究可以根据会员的产品组合长期计划进行调整。这种高度优先的研究和以产品为导向的研究通常仍然是每一家公司的重点，但总的来说，成员资格重视该中心的价值：-增加成员研究组合的广度和多样性。-致力于竞争前的技术，这些技术可能会在未来增加一些好处。-致力于有价值但成员公司既没有时间也没有资源去追求的替代方法。这也有助于成员更好地定位其现有的产品/技术方法。提供对可能超出公司范围的新兴研究领域的敞口，从而增加成员-S创新能力。在行业战略监督的指导下，研究项目将在理解细胞/宿主相互作用、新的生物标记物发现、护理点和互操作诊断、个性化癌症治疗以及许多其他将提高医疗质量的技术方面取得突破。该中心的研究与三个相互重叠的关键领域保持一致：生物成像、光学诊断和分析，每个关键领域都有系统、传感器和设备以及材料和生物领域的组成部分。Analytics研究的目标是在成像和诊断工具中嵌入数据检索和计算处理能力，以加深对收集的生物、基因、行为和环境数据的理解，以便能够在个人层面上做出医疗决策。加州大学戴维斯分校的网站将继续利用其科学专业知识、基础设施和研究能力，扩大生物光子传感器和系统的工具箱，并将这些新技术应用于更好、更快和更便宜的医疗保健。在第二阶段，我们计划从加州大学更多的校区聘请教师，从而进一步扩大中心/S的研究能力和专业知识。

项目成果

Investigation of the effect of directional (off-axis) illumination on the reflectivity of retina layers in mice using swept-source optical coherence tomography

使用扫源光学相干断层扫描研究定向（离轴）照明对小鼠视网膜层反射率的影响

• DOI: 10.1117/12.2288739
• 发表时间: 2018
• 期刊: Ophthalmic Technologies XXVIII; 104742B
• 作者: Meleppat, Ratheesh K.;Zhang, Pengfei;Wahl, Daniel J.;Jian, Yifan;Manna, Suman K.;Sarunic, Marinko V.;Pugh, Edward N.;Zawadzki, Robert J.;Ju, Myeong Jin;Manns, Fabrice
• 通讯作者: Manns, Fabrice

Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia.

• DOI: 10.1080/02713683.2017.1319491
• 发表时间: 2017-10
• 期刊: Current eye research
• 影响因子: 2
• 作者: Moisseiev E;Anderson JD;Oltjen S;Goswami M;Zawadzki RJ;Nolta JA;Park SS
• 通讯作者: Park SS

Adaptive optics with combined optical coherence tomography and scanning laser ophthalmoscopy for in vivo mouse retina imaging

自适应光学结合光学相干断层扫描和扫描激光检眼镜用于小鼠体内视网膜成像

• DOI: 10.1117/12.2288607
• 发表时间: 2018
• 期刊: SPIE Proceedings Vol. 10474: Ophthalmic Technologies XXVIII
• 作者: Zhang, Pengfei;Wahl, Daniel J.;Mocci, Jacopo;Manna, Suman K.;Meleppat, Ratheesh K.;Bonora, Stefano;Sarunic, Marinko V.;Pugh, Edward N.;Zawadzki, Robert J.;Manns, Fabrice
• 通讯作者: Manns, Fabrice

Feasibility study of Raman spectroscopy for investigating the mouse retina in vivo

拉曼光谱用于体内研究小鼠视网膜的可行性研究

• DOI: 10.1117/12.2288790
• 发表时间: 2018
• 期刊: Ophthalmic Technologies XXVIII; 104741J
• 作者: Zhang, Pengfei;Maleppat, Ratheesh K.;Pugh, Edward N.;de Oliveira, Marcos A.;Chang, Che-Wei;Chan, James W.;Zawadzki, Robert J.;Manna, Suman K.;Manns, Fabrice;Söderberg, Per G.
• 通讯作者: Söderberg, Per G.

Effect of a contact lens on mouse retinal in vivo imaging: Effective focal length changes and monochromatic aberrations.

• DOI: 10.1016/j.exer.2018.03.027
• 发表时间: 2018-07
• 期刊: Experimental eye research
• 影响因子: 3.4
• 作者: Zhang P;Mocci J;Wahl DJ;Meleppat RK;Manna SK;Quintavalla M;Muradore R;Sarunic MV;Bonora S;Pugh EN Jr;Zawadzki RJ
• 通讯作者: Zawadzki RJ