Doctoral Dissertation Research: The Influence of Infant-Caregiver Feeding Interactions on Diet, Growth and Metabolic Development

博士论文研究：婴儿与照顾者喂养互动对饮食、生长和代谢发育的影响

• 批准号: 1650751
• 负责人: Amanda Thompson
• 金额: $ 3.02万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1650751&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Influence; Infant

Research in human biology has provided evidence that early life factors shape later life outcomes through biological mechanisms. This dissertation research project will investigate linkages between physiological and nutritional aspects of early life and the risk of childhood and adult obesity, with a specific focus on diet, appetite and growth during the first year of life. The results will shed light on what kinds of diets during infancy might reduce obesity risk, and on social factors that help families make more optimal dietary choices. The project addresses fundamental questions in life history theory, and will be relevant to the well-being of the US population, for which obesity rates continue to increase. Data will be shared with clinical practitioners who advise families from all types of social backgrounds about nutrition for their children, and policy makers who focus on improving access to adequate nutrition for young children and their families. The project will also support student training in STEM research at the undergraduate and graduate levels.This project integrates social determinants of health and developmental origins of health and disease frameworks to investigate how social contexts influence access to nutrition and information about nutrition, and how the nutrition infants experience shapes long-term health. It also uses the concept of the developmental niche to explore how caregiver observations of infant growth and family mealtime interactions influence what and how infants eat. The investigator will follow Latino families with young infants from 3 to 12 months of age. Ethnographic interviews will be conducted to understand what kinds of factors influence how and what parents feed their infants. Survey and observational data will be collected to understand how infant appetite and mealtime interactions influence what and how much infants eat. Growth hormones and infant growth measurements will be collected to understand how infants' diets influence their growth and growth hormones. Appetite hormone analysis will be completed to understand how appetite hormones influence and are influenced by infant nutrition. The findings will illuminate how social contexts, family behaviors and infant biology are intertwined in ways that may influence obesity risk.

人类生物学研究提供的证据表明，早期生活因素通过生物机制塑造了后来的生活结果。本论文研究项目将调查早期生命的生理和营养方面与儿童和成人肥胖风险之间的联系，特别关注生命第一年的饮食，食欲和生长。研究结果将揭示婴儿期什么样的饮食可以降低肥胖风险，以及帮助家庭做出更优化饮食选择的社会因素。该项目解决了生命史理论中的基本问题，并将与美国人口的福祉相关，肥胖率继续增加。这些数据将与临床医生分享，他们为来自各种社会背景的家庭提供有关儿童营养的建议，并与政策制定者分享，他们专注于改善幼儿及其家庭获得充足营养的机会。该项目还将支持本科生和研究生阶段STEM研究的学生培训。该项目整合了健康的社会决定因素和健康与疾病框架的发展起源，以调查社会环境如何影响获得营养和营养信息，以及婴儿的营养经历如何塑造长期健康。它还使用了发展生态位的概念，探讨如何照顾婴儿的成长和家庭用餐时间的互动影响婴儿吃什么和如何观察。研究者将随访有3至12个月婴儿的拉丁美洲家庭。将进行民族志访谈，以了解什么样的因素影响父母如何喂养他们的婴儿。将收集调查和观察数据，以了解婴儿食欲和进餐时间的相互作用如何影响婴儿吃什么和吃多少。将收集生长激素和婴儿生长测量结果，以了解婴儿的饮食如何影响他们的生长和生长激素。将完成食欲激素分析，以了解食欲激素如何影响婴儿营养。这些发现将阐明社会环境、家庭行为和婴儿生物学如何以可能影响肥胖风险的方式交织在一起。