REU Site: A Cyberlinked Program in Computational Biomolecular Structure & Design

REU 网站：计算生物分子结构的网络链接程序

• 批准号: 1659649
• 负责人: Jeffrey Gray
• 金额: $ 42.7万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1659649&HistoricalAwards=false
• 关键词: REU; Site; Cyberlinked; Program; Computational

This REU Site award to Johns Hopkins University, located in Baltimore, MD, will support the training of 10 students for 10 weeks during the summers of 2017- 2019. The award is supported by the Divisions of Biological Infrastructure (BIO), Chemistry (MPS) and Engineering Education and Centers (ENG). Research is conducted in various labs of the Rosetta Commons (http://www.rosettacommons.org) located throughout the United States and abroad. The program consists of a 1-week boot camp where students learn computer coding and structural biology, 8 weeks of research in distributed labs, and a final week together at the Rosetta Conference. During the research period, students will complete an independent research project under the mentorship of a host lab, participate in weekly virtual journal clubs, prepare research proposals, and prepare a poster for presentation at the conference. Upon completion of the REU program, students will gain an understanding of how to investigate biological problems from a structural perspective; experience computational molecular design; acquire a solid foundation in research methodologies in biochemistry, biophysics, computational biology, and molecular engineering; gain skills to collaborate with other scientists and engineers in other laboratories globally; and gain a deeper appreciation for the contributions that improved technology in these areas can make to society.It is anticipated that a total of 30 students, primarily from schools with limited research opportunities, will be trained in the program. Recruiting and outreach efforts focus on women and underrepresented minorities, and the program will recruit at outreach conferences like the Grace Hopper Conference and the Annual Biomedical Research Conference for Minority Students. Students will have the opportunity to present and/or publish their work. A common web-based assessment tool used by all REU Site programs funded by the Division of Biological Infrastructure will be used to determine the effectiveness of the training program. Students will be tracked after the program to determine their career paths. Students will be asked to respond to an automatic email sent via the NSF reporting system. More information about the program is available by visiting http://www.rosettacommons.org/intern, or by contacting the PI (Dr. Jeffrey J. Gray at [e-mail]) or the program administrator (Ms. Camille Mathis at [e-mail]).

这项授予位于马里兰州巴尔的摩的约翰·霍普金斯大学的REU Site奖将支持2017-2019年夏季为期10周的10名学生的培训。该奖项由生物基础设施(BIO)、化学(MPS)和工程教育与中心(ENG)部门支持。研究在位于美国和国外的Rosetta Commons(http://www.rosettacommons.org))的各个实验室进行。该计划包括为期一周的新兵训练营，学生们在那里学习计算机编码和结构生物学，在分散的实验室中进行为期8周的研究，以及在Rosetta会议上一起学习最后一周。在研究期间，学生将在主办实验室的指导下完成一个独立的研究项目，参加每周一次的虚拟期刊俱乐部，准备研究提案，并准备一张海报在会议上展示。完成REU项目后，学生将了解如何从结构角度研究生物问题；体验计算分子设计；在生物化学、生物物理、计算生物学和分子工程方面获得坚实的研究方法论基础；获得与全球其他实验室的其他科学家和工程师合作的技能；并更深入地了解这些领域改进的技术可以为社会做出的贡献。预计共有30名学生将在该计划中接受培训，主要来自研究机会有限的学校。招聘和外展工作的重点是女性和代表性不足的少数族裔，该项目将在格雷斯·霍珀会议和面向少数族裔学生的年度生物医学研究会议等外展会议上招聘。学生将有机会展示和/或发表他们的作品。将使用生物基础设施司资助的所有REU站点方案使用的通用网络评估工具来确定培训方案的有效性。项目结束后，将对学生进行跟踪，以确定他们的职业道路。学生将被要求回复通过NSF报告系统发送的自动电子邮件。欲了解更多有关该方案的信息，请访问http://www.rosettacommons.org/intern，，或联系国际组织(杰弗里·J·格雷博士，电子邮件：[e-mail])或方案管理员(Camille Mathis女士，电子邮件：[e-mail])。

项目成果

An Automated Data-Driven Pipeline for Improving Heterologous Enzyme Expression

用于改善异源酶表达的自动化数据驱动管道

• DOI: 10.1021/acssynbio.8b00486
• 发表时间: 2019
• 期刊: ACS Synthetic Biology
• 影响因子: 4.7
• 作者: Wrenbeck, Emily E.;Bedewitz, Matthew A.;Klesmith, Justin R.;Noshin, Syeda;Barry, Cornelius S.;Whitehead, Timothy A.
• 通讯作者: Whitehead, Timothy A.