REU Site: A Cyberlinked Program in Computational Biomolecular Structure & Design

REU 网站：计算生物分子结构的网络链接程序

• 批准号: 1659649
• 负责人: Jeffrey Gray
• 金额: $ 42.7万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1659649&HistoricalAwards=false
• 关键词: REU; Site; Cyberlinked; Program; Computational

This REU Site award to Johns Hopkins University, located in Baltimore, MD, will support the training of 10 students for 10 weeks during the summers of 2017- 2019. The award is supported by the Divisions of Biological Infrastructure (BIO), Chemistry (MPS) and Engineering Education and Centers (ENG). Research is conducted in various labs of the Rosetta Commons (http://www.rosettacommons.org) located throughout the United States and abroad. The program consists of a 1-week boot camp where students learn computer coding and structural biology, 8 weeks of research in distributed labs, and a final week together at the Rosetta Conference. During the research period, students will complete an independent research project under the mentorship of a host lab, participate in weekly virtual journal clubs, prepare research proposals, and prepare a poster for presentation at the conference. Upon completion of the REU program, students will gain an understanding of how to investigate biological problems from a structural perspective; experience computational molecular design; acquire a solid foundation in research methodologies in biochemistry, biophysics, computational biology, and molecular engineering; gain skills to collaborate with other scientists and engineers in other laboratories globally; and gain a deeper appreciation for the contributions that improved technology in these areas can make to society.It is anticipated that a total of 30 students, primarily from schools with limited research opportunities, will be trained in the program. Recruiting and outreach efforts focus on women and underrepresented minorities, and the program will recruit at outreach conferences like the Grace Hopper Conference and the Annual Biomedical Research Conference for Minority Students. Students will have the opportunity to present and/or publish their work. A common web-based assessment tool used by all REU Site programs funded by the Division of Biological Infrastructure will be used to determine the effectiveness of the training program. Students will be tracked after the program to determine their career paths. Students will be asked to respond to an automatic email sent via the NSF reporting system. More information about the program is available by visiting http://www.rosettacommons.org/intern, or by contacting the PI (Dr. Jeffrey J. Gray at [e-mail]) or the program administrator (Ms. Camille Mathis at [e-mail]).

这个REU网站奖给约翰霍普金斯大学，位于马里兰州巴尔的摩，将支持10名学生在2017年至2019年的夏天10周的培训。该奖项由生物基础设施（BIO），化学（MPS）和工程教育和中心（ENG）部门支持。研究在Rosetta Commons（http：//www.example.com）的各个实验室进行，这些实验室遍布美国和国外。www.rosettacommons.org该计划包括为期1周的靴子营地，学生学习计算机编码和结构生物学，8周的分布式实验室研究，以及最后一周在罗塞塔会议上一起。在研究期间，学生将在主机实验室的指导下完成一个独立的研究项目，参加每周的虚拟期刊俱乐部，准备研究提案，并准备在会议上展示的海报。完成REU课程后，学生将了解如何从结构角度研究生物学问题;体验计算分子设计;获得生物化学，生物物理学，计算生物学和分子工程研究方法的坚实基础;获得与全球其他实验室的其他科学家和工程师合作的技能;并对这些领域的技术进步对社会的贡献有更深的认识。预计共有30名学生将参加该计划，他们主要来自研究机会有限的学校。招聘和外联工作的重点是妇女和代表性不足的少数民族，该计划将在外联会议上招聘，如格雷斯霍珀会议和少数民族学生年度生物医学研究会议。学生将有机会展示和/或发表他们的作品。 由生物基础设施部资助的所有REU研究中心项目使用的通用网络评估工具将用于确定培训项目的有效性。学生将在课程结束后进行跟踪，以确定他们的职业道路。学生将被要求通过NSF报告系统自动发送电子邮件。有关该计划的更多信息，请访问http：//www.rosettacommons.org/intern，或联系PI（Jeffrey J. Gray博士，[e-mail]）或计划管理员（Camille马西斯女士，[e-mail]）。

项目成果

An Automated Data-Driven Pipeline for Improving Heterologous Enzyme Expression

用于改善异源酶表达的自动化数据驱动管道

• DOI: 10.1021/acssynbio.8b00486
• 发表时间: 2019
• 期刊: ACS Synthetic Biology
• 影响因子: 4.7
• 作者: Wrenbeck, Emily E.;Bedewitz, Matthew A.;Klesmith, Justin R.;Noshin, Syeda;Barry, Cornelius S.;Whitehead, Timothy A.
• 通讯作者: Whitehead, Timothy A.