EAGER: A New Model for Undergraduate Training: a Virtual Community of Researchers in Computational Biomolecular Structure & Design

EAGER：本科生培训新模式：计算生物分子结构研究人员的虚拟社区

• 批准号: 1541278
• 负责人: Jeffrey Gray
• 金额: $ 20.77万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1541278&HistoricalAwards=false
• 关键词: EAGER; New; Model; Undergraduate; Training

This EAGER award to Johns Hopkins University will test the efficacy of a distributed model of student training that uses virtual technologies for collaboration. The grant will support the training of 8 students for 10 weeks during the summers of 2015- 2016. Students will be trained in biomolecular structure and design, using the Rosetta software. Students attend a boot camp in Week 1 to learn how to use the software, including use of Python and C++ languages. Students then go to an assigned lab where they do research at the intersection of chemistry, biology, computer science and engineering. In Week 10, the students gather for presentation of their results and to exchange ideas. At the end of 10 weeks, students will have learned how research is conducted and will have presented the results of their work at a scientific conference. Upon completing the program, the students will have a greater understanding of research in the area of computational biomolecular design and structure prediction, and they will have learned the use of the Rosetta software. Assessment of the effectiveness of the training will be done thru the SALG URSSA survey instrument (available online at www.bioreu.org). Mentors come from the Rosetta Commons network, and students can choose from a variety of projects such as designing proteins that can produce fuels in microbes, writing algorithms for vaccine design, developing models of protein glycosylation in abnormal cells, and others. Students participate in virtual seminars/workshops scheduled every week, and they interact daily with students thru virtual technologies such as Skype, Google chat, etc. Training in ethics and the responsible conduct of research is included as well as exposure to various careers in STEM. Students will be tracked after the program thru an automatic email sent via the NSF reporting system. More information is available by visiting http://rosettacommons.org/intern, or by contacting the PI (Dr. Jeffrey Gray at [e-mail]) or the Program Manager (Gregg Nass at [e-mail]). This award is supported by the Division of Biological Infrastructure (DBI) in the Directorate for Biological Sciences (BIO), the Division of Advanced Cyberinfrastructure (ACI) in the Directorate for Computer and Information Science & Engineering (CISE), and the Division of Chemistry (CHE) in the Directorate for Mathematical and Physical Sciences (MPS).

约翰霍普金斯大学的EAGER奖将测试使用虚拟技术进行协作的分布式学生培训模型的有效性。该赠款将支持8名学生在2015- 2016年夏季进行为期10周的培训。学生将接受生物分子结构和设计方面的培训，使用Rosetta软件。学生们在第一周参加一个靴子训练营，学习如何使用软件，包括使用Python和C++语言。然后，学生们去一个指定的实验室，在那里他们做化学，生物学，计算机科学和工程的交叉研究。在第10周，学生们聚集在一起展示他们的成果，并交换意见。在10周结束时，学生将学习如何进行研究，并将在科学会议上介绍他们的工作成果。在完成该计划后，学生将有一个更好的了解在计算生物分子设计和结构预测领域的研究，他们将学习使用罗塞塔软件。将通过SALG URSSA调查工具（可在www.bioreu.org在线查阅）对培训的有效性进行评估。导师来自Rosetta Commons网络，学生可以从各种项目中进行选择，例如设计可以在微生物中产生燃料的蛋白质，编写疫苗设计算法，开发异常细胞中蛋白质糖基化的模型等。学生每周参加虚拟研讨会/讲习班，他们每天通过Skype，谷歌聊天等虚拟技术与学生互动。课程结束后，学生将通过NSF报告系统自动发送的电子邮件进行跟踪。 欲了解更多信息，请访问http：//rosettacommons.org/intern，或联系PI（Jeffrey Gray博士，[e-mail]）或项目经理（Gregg Nass，[e-mail]）。该奖项由生物科学局（BIO）的生物基础设施部（DBI），计算机和信息科学工程局（CISE）的高级网络基础设施部（ACI）以及数学和物理科学局（MPS）的化学部（CHE）支持。

项目成果

Massively parallel, computationally guided design of a proenzyme.

• DOI: 10.1073/pnas.2116097119
• 发表时间: 2022-04-12
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

An Automated Data-Driven Pipeline for Improving Heterologous Enzyme Expression

用于改善异源酶表达的自动化数据驱动管道

• DOI: 10.1021/acssynbio.8b00486
• 发表时间: 2019
• 期刊: ACS Synthetic Biology
• 影响因子: 4.7
• 作者: Wrenbeck, Emily E.;Bedewitz, Matthew A.;Klesmith, Justin R.;Noshin, Syeda;Barry, Cornelius S.;Whitehead, Timothy A.
• 通讯作者: Whitehead, Timothy A.