Calcium regulation in the skeletal muscle triad and along the fibre.

骨骼肌三联体和纤维中的钙调节。

• 批准号: DP0879780
• 负责人: Prof Bradley Launikonis
• 金额: $ 11.36万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-04-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879780
• 关键词: Calcium; regulation; skeletal; muscle; triad

The fundamental role of skeletal muscle is posture and movement. Alterations in the normal way calcium regulates skeletal muscle function in fatigue, age and disease states causes loss of normal function. Preventing or controlling these changes is a key therapeutic aim. However, we currently lack full understanding of key mechanisms of calcium regulation in healthy skeletal muscle. This project will define key aspects of calcium regulation that could be crucial to developing targets for improving function of skeletal muscle under stressed states.

骨骼肌的基本作用是姿势和运动。钙调节骨骼肌功能的正常方式在疲劳、年龄和疾病状态下的改变会导致正常功能的丧失。 预防或控制这些变化是一个关键的治疗目标。 然而，我们目前缺乏对健康骨骼肌钙调节的关键机制的充分理解。 该项目将定义钙调节的关键方面，这对于开发在应激状态下改善骨骼肌功能的目标至关重要。