SGER: Histopathological Examination of the Brain of the Amnesic Patient H.M.

这个项目的目标是保存和成像心理学历史上最著名的患者之一的大脑，H.M.现年80岁，他在1953年接受了一次实验性手术，以缓解医学上难以治愈的癫痫；从那时起，他一直严重健忘。手术报告表明，切除包括杏仁核，大部分海马体，以及两侧大脑半球周围的海马旁皮质。他参与的实验结果使学习和记忆的研究发生了革命性的变化。尽管我们有许多他大脑的磁共振图像，但这些图像的分辨率限制使我们保护大脑本身变得重要。H.M.已经奄奄一息，这个项目将使他的大脑在死亡后能够及时保存下来。(组织几乎立即开始退化，因此这项工作必须迅速进行。)一旦这个项目完成，已经涉及H.M.的数十项研究将被重新审视。保存这位著名患者的大脑，使其在目前的核磁共振扫描中看不到细节，将对记忆和脑研究领域具有重要价值。广泛的科学家将对这种组织保存产生的扫描感兴趣。这位患者世界闻名，拥有这个数据库将是美国S在科学领域地位的一笔财富。

The goal of this project is to preserve and image the brain of one of the most famous patients in the history of psychology, H. M. Now 80 years old, he underwent an experimental operation in 1953 for the relief of medically intractable epilepsy; since that time, he has been profoundly amnesic. Reports from the surgery indicate that the resection included the amygdala, most of the hippocampus, and surrounding parahippocampal cortex in both hemispheres. The results of experiments in which he participated revolutionized the study of learning and memory. Although we have many magnetic resonance images of his brain, the limits on the resolution of those images make it important for us to preserve the brain itself. H. M. is on his deathbed, and this project will allow the time-sensitive preservation of his brain once death occurs. (The tissue starts to deteriorate almost immediately, so the work has to happen quickly.) The dozens of studies that have already involved H. M. will be seen in a new light once this project is complete. The brain basis of memory will be much clearer then.Having the brain of this famous patient preserved so that details not visible in current MRI scans will be available will be of great value to the fields of memory and brain research. A wide range of scientists will be interested in the scans that will arise from this tissue preservation. This patient is famous world-wide, and having this database will be an asset to the U.S.'s position within the scientific field.