SGER: Histopathological Examination of the Brain of the Amnesic Patient H.M.

SGER：失忆症患者大脑的组织病理学检查

• 批准号: 0714660
• 负责人: Jacopo Annese
• 金额: --
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0714660&HistoricalAwards=false
• 关键词: SGER; Histopathological; Examination; Brain; Amnesic

The goal of this project is to preserve and image the brain of one of the most famous patients in the history of psychology, H. M. Now 80 years old, he underwent an experimental operation in 1953 for the relief of medically intractable epilepsy; since that time, he has been profoundly amnesic. Reports from the surgery indicate that the resection included the amygdala, most of the hippocampus, and surrounding parahippocampal cortex in both hemispheres. The results of experiments in which he participated revolutionized the study of learning and memory. Although we have many magnetic resonance images of his brain, the limits on the resolution of those images make it important for us to preserve the brain itself. H. M. is on his deathbed, and this project will allow the time-sensitive preservation of his brain once death occurs. (The tissue starts to deteriorate almost immediately, so the work has to happen quickly.) The dozens of studies that have already involved H. M. will be seen in a new light once this project is complete. The brain basis of memory will be much clearer then.Having the brain of this famous patient preserved so that details not visible in current MRI scans will be available will be of great value to the fields of memory and brain research. A wide range of scientists will be interested in the scans that will arise from this tissue preservation. This patient is famous world-wide, and having this database will be an asset to the U.S.'s position within the scientific field.

该项目的目标是保存心理学史上最著名的患者之一H的大脑并对其进行成像。M. 现年80岁的他在1953年接受了一次实验性手术，以缓解医学上难以治愈的癫痫;从那时起，他就严重失忆了。手术报告显示，切除的部分包括杏仁核、大部分海马体和左右半球海马旁皮质。他参与的实验结果彻底改变了学习和记忆的研究。虽然我们有很多他大脑的磁共振图像，但这些图像分辨率的限制使我们必须保护大脑本身。 H. M.他即将去世，这个项目将允许他的大脑在死亡发生后及时保存。 (The组织几乎立即开始恶化，因此工作必须迅速进行。） 已经有几十项研究涉及H. M.在这个项目完成后将以新的眼光看待。 届时，记忆的大脑基础将更加清晰。保存这位著名患者的大脑，以便获得目前MRI扫描无法看到的细节，这对记忆和大脑研究领域具有重大价值。 广泛的科学家将对这种组织保存所产生的扫描感兴趣。 这个病人是世界闻名的，拥有这个数据库将是美国的一笔财富。在科学领域的地位。