Magnetic Ionic Liquids as Tunable Solvents for Sample Preparation and Chemical Analysis

磁性离子液体作为样品制备和化学分析的可调溶剂

• 批准号: 1709372
• 负责人: Jared Anderson
• 金额: $ 41.7万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709372&HistoricalAwards=false
• 关键词: Magnetic; Ionic; Liquids; Tunable; Solvents

This project is funded by the Chemical Measurement and Imaging (CMI) program in the Division of Chemistry. Professor Jared L. Anderson of Iowa State University is developing new separation media based on magnetic ionic liquids for sample preparation and chromatography methods. Magnetic ionic liquids are non-molecular solvents that possess low melting points, high stability, and can be controlled by an applied magnetic field. The proposed work will develop new advancements in nucleic acid analysis and have a major impact in various interdisciplinary fields including clinical diagnostics, biomedicine, and forensics. This project focuses on three areas where magnetic ionic liquids are studied and used in chemical measurement. Magnetic ionic liquids are designed and incorporated into chromatographic separations; new approaches are developed to achieve sequence specific extraction of deoxyribonucleic acid; and the preservation of ribonucleic acid structure is studied using magnetic ionic liquids as solvents. This research provides fundamental new knowledge about these materials and catalyzes the development of new approaches for achieving rapid and selective nucleic acid analysis. Graduate and undergraduate students acquire training in separation science and bioanalytical chemistry. High school students participate in the research through the American Chemical Society Project SEED program. A social networking program is used to disseminate scientific videos to young children and the general public.

该项目由化学部的化学测量和成像（CMI）计划资助。Jared L.教授爱荷华州州立大学的安德森正在开发基于磁性离子液体的新分离介质，用于样品制备和色谱方法。磁性离子液体是一种非分子溶剂，具有低熔点、高稳定性，并可通过外加磁场控制。拟议的工作将在核酸分析方面取得新进展，并对临床诊断、生物医学和法医学等各个跨学科领域产生重大影响。本项目主要研究磁性离子液体在化学测量中的应用。设计了磁性离子液体并将其用于色谱分离;开发了实现脱氧核糖核酸序列特异性提取的新方法;并研究了使用磁性离子液体作为溶剂保持核糖核酸结构。这项研究提供了关于这些材料的基本新知识，并促进了实现快速和选择性核酸分析的新方法的发展。研究生和本科生获得分离科学和生物分析化学的培训。高中生通过美国化学学会项目SEED计划参与研究。一个社交网络计划被用来向幼儿和公众传播科学视频。

项目成果

Selective extraction of low-abundance BRAF V600E mutation from plasma, urine, and sputum using ion-tagged oligonucleotides and magnetic ionic liquids

• DOI: 10.1007/s00216-021-03216-8
• 发表时间: 2021-03-01
• 期刊: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
• 影响因子: 4.3
• 作者: Emaus，Miranda N.;Anderson，Jared L.
• 通讯作者: Anderson，Jared L.

Polymeric ionic liquid sorbent coatings in headspace solid-phase microextraction: A green sample preparation technique for the determination of pesticides in soil

• DOI: 10.1016/j.microc.2020.104996
• 发表时间: 2020-09
• 期刊: Microchemical Journal
• 影响因子: 4.8
• 作者: D. Orazbayeva;J. Koziel;M. J. Trujillo-Rodríguez;Jared L. Anderson;B. Kenessov

High-throughput approach for the in situ generation of magnetic ionic liquids in parallel-dispersive droplet extraction of organic micropollutants in aqueous environmental samples

在水环境样品中有机微污染物的平行分散液滴萃取中原位生成磁性离子液体的高通量方法

• DOI: 10.1016/j.talanta.2020.121759
• 发表时间: 2021
• 期刊: Talanta
• 影响因子: 6.1
• 作者: Will, Camila;Huelsmann, Ricardo Dagnoni;Mafra, Gabriela;Merib, Josias;Anderson, Jared L.;Carasek, Eduardo
• 通讯作者: Carasek, Eduardo

Immobilization of phosphonium-based ionic liquid stationary phases extends their operative range to routine applications in the flavor, fragrance and natural product fields

鏻基离子液体固定相的固定化将其操作范围扩展到香料、香料和天然产品领域的常规应用

• DOI: 10.1016/j.chroma.2021.462796
• 发表时间: 2022
• 期刊: Journal of Chromatography A
• 影响因子: 4.1
• 作者: Cagliero, Cecilia;Bizzo, Humberto;Rubiolo, Patrizia;Marengo, Arianna;Galli, Stefano;Anderson, Jared L.;Sgorbini, Barbara;Bicchi, Carlo
• 通讯作者: Bicchi, Carlo

Tunable Silver-Containing Stationary Phases for Multidimensional Gas Chromatography

用于多维气相色谱的可调含银固定相

• DOI: 10.1021/acs.analchem.9b00472
• 发表时间: 2019
• 期刊: Analytical Chemistry
• 影响因子: 7.4
• 作者: Souza, Israel D.;Nan, He;Queiroz, Maria Eugênia;Anderson, Jared L.
• 通讯作者: Anderson, Jared L.