SBIR Phase I: Medical Devices for Real-time Radiation Dosimetry at Sub-millimeter Spatial Resolution

SBIR 第一阶段：用于亚毫米空间分辨率实时辐射剂量测量的医疗设备

• 批准号: 1721296
• 负责人: David Lewis
• 金额: $ 22.5万
• 依托单位: eBeam Film LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1721296&HistoricalAwards=false
• 关键词: SBIR; Phase; Medical; Devices; Real

This Small Business Innovation Research Phase I project seeks development of a novel dosimeter for 2-D mapping of radiation dose in real-time at sub-millimeter spatial resolution. The high spatial resolution of the dosimeter is essential in supporting stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) treatments. These rapidly emerging modalities deliver precise doses of radiation to small, well defined treatment sites while minimizing exposure of critical neighboring anatomy. With the annual number of SRS/SBRT treatments approaching 1,000,000 and growing 5-10% annually there is a market need for a dosimeter with sub-millimeter resolution and the capability of measuring in real-time. The routine pre-treatment verification of each patient therapy plan becomes a target application. The value of the market for the dosimeter alone exceeds $10 million annually. The value is amplified through enablement of the safe and efficacious delivery of SRS and SBRT treatments. Use of these modalities greatly impacts the efficiency of radiotherapy by substantially reducing the number of individual sessions in a course of treatment. The net result is lower cost for the treatment course, an increase in the number of patients/year for each linear accelerator equipment unit and a large reported improvement in patient outcomes. The intellectual merit of this project lies in combining and adapting key elements of two well-established commercial technologies, piezoelectric polymers and radiochromic film, to produce a hybrid dosimeter. This dosimeter preserves the high spatial resolution of radiochromic film while improving its usability by making the changes caused by radiation exposure to become detectable by electronic means in real-time. During use, the flexible, single-use piezoelectric array dosimeter (PARD) fits into a re-usable data acquisition electronics module that transmits a map of measured doses to a Medical Physicist outside the radiation cell. Radiochromic film, the only current dosimeter with sub-millimeter spatial resolution, is inconvenient owing to the long delay between exposure and measurement as well as the extra time and effort in facilitating the measurements. This drawback adversely impacts its usefulness in the day-to-day verification of patient treatment plans. The hybrid PARD product provides a dense, flexible array (0.1 mm spacing) of detectors with the unique ability for dose measurement at sub-millimeter resolution in real time. This overcomes key drawbacks of existing electronic array devices which are incapable of spatial resolution below 5 mm and unsuitable for the small radiation fields associated with SRs and SBRT treatments.

这个小型企业创新研究第一阶段项目寻求开发一种新型剂量计，用于以亚毫米空间分辨率实时绘制辐射剂量图。高空间分辨率的剂量计对于支持立体定向放射外科(SRS)和立体定向全身放射治疗(SBRT)是必不可少的。这些快速出现的治疗方式将精确剂量的辐射提供给定义明确的小治疗部位，同时将关键邻近解剖结构的暴露降至最低。随着每年SRS/SBRT治疗的数量接近100万次，并以每年5-10%的速度增长，市场上对具有亚毫米分辨率和实时测量能力的剂量计的需求越来越大。每个患者治疗计划的常规治疗前验证成为目标应用。仅剂量计的市场价值每年就超过1000万美元。通过安全有效地提供SRS和SBRT治疗，这一价值被放大。这些模式的使用极大地影响了放射治疗的效率，因为它大大减少了治疗过程中个别疗程的次数。最终结果是降低了疗程的成本，每个直线加速器设备单位的患者数量/年增加了，据报道患者结果有了很大改善。该项目的智能优点在于将两种成熟的商业技术--压电聚合物和辐射变色薄膜--的关键元素结合起来并进行调整，以生产出混合剂量计。这种剂量计保留了辐射变色胶片的高空间分辨率，同时通过使辐射暴露引起的变化可以通过电子手段实时检测来提高其可用性。在使用过程中，灵活的一次性压电阵列剂量计(PARD)适合于可重复使用的数据采集电子模块，该模块将测量的剂量图传输给辐射单元外的医学物理学家。辐射变色胶片是目前唯一具有亚毫米空间分辨率的剂量计，由于曝光和测量之间的长时间延迟以及为测量提供额外的时间和精力而带来的不便。这一缺陷对其在患者治疗计划的日常验证中的有用性产生了不利影响。混合PARD产品提供了密集、灵活的探测器阵列(间距0.1 mm)，具有以亚毫米分辨率进行实时剂量测量的独特能力。这克服了现有电子阵列设备的主要缺陷，这些设备不能达到低于5 mm的空间分辨率，并且不适合与SRS和SBRT治疗相关的小辐射场。