Workshop on Microsystems for Electroceuticals and Bioelectronic Medicine, April 12-13, 2017, IBM Conference Center Washington DC.

本提案要求组织一个研讨会，探讨与个性化医疗的生物电子微系统相关的科学问题和技术挑战，该系统能够使用尺寸小于100微米的微小设备治疗多种疾病，该设备能够执行体内传感和与单个活细胞的直接电相互作用。本次研讨会的目标是制定一份技术能力路线图，以便在2022年之前实现原型生物电微电池，从而使美国处于这项技术的前沿。该提案要求为参加将于2017年4月12日至13日在华盛顿IBM会议中心举行的NSF-SRC“电子和生物电子医学微系统”研讨会的专家提供旅费和生活费支持。由于大规模集成电子的复杂性要求跨学科的知识需求，这些讨论也将为教育带来必要的机遇和变革。生物电子医疗设备的开发需要多学科的知识和技能，包括神经科学、医学、系统工程、材料、电子等。研讨会将有助于确定未来生物医学工程本科和研究生课程的需求。委员会计划在委员会的会议网站上公布会议结果，以供公众查阅。研讨会的会议记录和建议清单将提供给研讨会的所有参与者、国家科学基金会、其他政府科学家、工业界和决策者。生物电子医学预示着一个实时、个性化医疗诊断和治疗的新时代。生物电子医学的微系统被设想为一种利用电流来影响和改变身体功能的医疗设备，作为药物干预的替代方案。这组新兴设备也被称为“电子药品”。目前，这方面的研究还处于起步阶段。本次NSF/SRC技术交流会旨在制定未来的研究议程，推动“生物电微细胞”在生物电子医学领域的科学探索。它将探索合成生物学和混合生物电子系统的半导体平台的科学与工程交叉点的想法，以解决从生物电子医学的微系统的基础和应用；用于治疗的电子信号处理；利用半导体技术制造替代药物的生物电微电池的实现生物电微细胞技术的生物相容性问题最后是从研究到商业化的发展路线图。该研讨会将提供一个极好的机会，以知识追求和识别与生物电子医学新方法相关的科学挑战。

This proposal request is for the organization of a workshop to explore the scientific issues and technological challenges associated with bioelectronic microsystems for personalized medicine with an ability to treat a wide range of diseases with a tiny device less than 100 microns in size that is capable of performing in-vivo sensing and direct electrical interactions with a single living cell. The goal of this workshop will be to develop a roadmap of technology capabilities that are needed to enable a prototypical bioelectromicrocell by 2022 in order to position the U.S. at the forefront of this technology. This proposal requests support to provide travel funds and subsistence for experts to participate in the NSF-SRC workshop on 'Microsystems for Electroceuticals and Bioelectronic Medicine' to be held on April 12-13, 2017 at the IBM Conference Center in Washington DC. The discussions will also bring out opportunities and changes necessary in education as the complexity of the large scale integrated electronics demands interdisciplinary knowledge needs. Development of bioelectronic medical devices requires multidisciplinary knowledge and skills, including neuroscience, medicine, systems engineering, materials, electronics. The workshop will help to identify needs for future undergraduate and graduate curriculum in Biomedical Engineering. Plans are to disseminate the outcome of the meeting by posting presentation materials on the meeting website of SRC for the general public. The proceedings of the workshop and the list of recommendations will be made available to all participants of the workshop, NSF, other government scientists, industry and policymakers.Bioelectronic Medicine promises a new era of real-time, personalized medical diagnosis and treatment. Microsystems for Bioelectronic Medicine are envisioned as medical devices that employ electrical currents to affect and modify body functions as an alternative to drug-based interventions. This group of emerging devices is also referred to as 'electroceuticals'. Currently, research on this topics is still in its infancy stage. This NSF/SRC technical exchange meeting is organized to develop future research agenda that enable the scientific explorations on 'bioelectromicrocell' for bioelectronics medicine. It will explore ideas at the intersection of science and engineering of semiconductor platforms for synthetic biology and hybrid bioelectronics systems to address the key questions ranging from the fundamentals and application of microsystems for bioelectronic medicine; electronic signal treatment for therapeutic applications; realization for the fabrication of bioelectromicrocell for replacing drugs by semiconductor technologies; biocompatibility issues of bioelectromicrocell technologies; and finally the development of roadmap from research to commercialization. The workshop will provide an excellent opportunity for intellectual pursuit and discernment of scientific challenges related to new approaches for bioelectronics medicine.