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Characterization of hypoxic tumor areas in high grade gliomas by means of simultaneous PET/MRT

通过同步 PET/MRI 表征高级别胶质瘤缺氧肿瘤区域

基本信息

批准号：
231164260
负责人：
Professorin Dr. Christine Preibisch
金额：
--
依托单位：
Neurochirurgische Klinik und Poliklinik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/231164260?language=en
关键词：
Characterization hypoxic tumor areas grade

项目摘要

High-grade glioma are highly malignant, proliferating brain tumors, which tend to be hypoxic and diffusely infiltrate the surrounding healthy brain tissue. Hypoxia plays an important role with respect to differentiation of tumor stem cells, resistance to radiation therapy, neoangiogenesis and resulting cell proliferation. Notably, tumor hypoxia is closely correlated with a poor clinical patient outcome. Therefore, the aim of the proposed project is a comprehensive characterization of hypoxic brain tumor areas by means of a combined innovative hypoxia-sensitive magnetic resonance imaging (MRI) and positron emission tomography (PET) approach in untreated patients with tentative diagnosis of high-grade glioma. The main intention is to establish innovative multimodal hypoxia-related imaging biomarkers. Since tumor hypoxia may be subject to a high temporal and spatial variability, a novel method which allows simultaneous measurement of MR-based post-capillary venous oxygen saturation and PET-based intra-cellular hypoxia (using 18F-Fluoromisonidazole (18F-FMISO), will be applied on a new, combined PET/MRI scanner (SIEMENS Biograph mMR). Using an optimized PET-based delineation of the metabolic tumor volume, with the well-established amino acid radiotracer 18F-Fluorethylthyrosine (18F-FET), hypoxic tumor areas in the metabolic tumor volume are to be identified by the novel MRI and PET hypoxia markers. Additionally, targeted stereotactic tumor biopsies will be obtained in order to correlate MRI- and PET-hypoxia-measures with different immunohistochemistry markers of hypoxia. Finally, in a comprehensive appraisal of all results, the patient outcome will be evaluated on the basis of dichotomous hypoxia categorization.

高级别胶质瘤是高度恶性、增殖性脑肿瘤，其倾向于缺氧并弥漫性浸润周围健康脑组织。缺氧在肿瘤干细胞的分化、对放射治疗的抵抗、新血管生成和由此产生的细胞增殖方面起重要作用。值得注意的是，肿瘤缺氧与不良临床患者结局密切相关。因此，该项目的目的是通过联合创新的缺氧敏感性磁共振成像（MRI）和正电子发射断层扫描（PET）方法，对未经治疗的高级别胶质瘤患者的缺氧脑肿瘤区域进行全面表征。主要目的是建立创新的多模式缺氧相关的成像生物标志物。由于肿瘤缺氧可能具有较高的时间和空间变异性，因此将在新的组合PET/MRI扫描仪（SIEMENS Biograph mMR）上应用一种新方法，该方法允许同时测量基于MR的毛细血管后静脉血氧饱和度和基于PET的细胞内缺氧（使用18 F-氟咪唑（18 F-FMISO））。使用优化的基于PET的代谢肿瘤体积描绘，使用成熟的氨基酸放射性示踪剂18 F-氟甲基甲状腺素（18 F-FET），通过新型MRI和PET缺氧标记物识别代谢肿瘤体积中的缺氧肿瘤区域。此外，将获得靶向立体定向肿瘤活检，以将MRI和PET缺氧测量与不同的缺氧免疫组织化学标志物相关联。最后，在所有结果的综合评价中，将根据二分缺氧分类评价患者结局。