Planning Grant: Industry University Cooperative Research Center (IUCRC) for Bioanalytic Metrology (CBM), University of Notre Dame

规划资助：圣母大学生物分析计量学产学合作研究中心（IUCRC）

• 批准号: 1747764
• 负责人: Paul Bohn
• 金额: $ 1.5万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1747764&HistoricalAwards=false
• 关键词: Planning; Grant; Industry; University; Cooperative

This proposal entails planning for an Industry-University Collaborative Research Center for Bioanalytic Metrology, a joint effort of the University of Notre Dame, Indiana University, and Purdue University. Planning activities will bring together a national coalition of analytical instrument makers, pharmaceutical companies, clinical practitioners, academic researchers, and other stakeholders, and unite them in a mission to design and build new, industry-critical systems for chemical measurement and bioanalysis. These systems are needed to address a fundamental gap in U.S. research and development; namely, the ability to fully identify, characterize, and track biological molecules within human cells and understand their many complex interactions. If established, the technical spin-offs from the center will have direct and tangible benefits for drug discovery, molecular diagnostics, clinical biotechnology, and other areas. Moreover, the capabilities envisioned by the center are necessary for the implementation of other long-term objectives, such as precision medicine. In addition to this knowledge transfer, the center will also help train a new and diverse bioanalytical workforce. The outcomes of the planning exercise will form the basis of a proposal to the National Science Foundation to establish a Center for Bioanalytic Metrology. Genomics, proteomics, metabolomics and bioinformatics provide a holistic framework to study biological systems with applications ranging from fundamental studies of biological systems to the design and use of diagnostics and therapeutics for personalized medicine. To realize the promise of these technologies, however, we must increase the depth of analysis of proteins, metabolites and other biomolecular species beyond current limits, thus reducing the fraction of detected, but unidentified, species collectively known as the ?dark molecules of life.' This planning grant lays the groundwork for a Center for Bioanalytic Metrology (CBM), joining expertise at Notre Dame, Indiana, and Purdue. Planning activities will bring together analytical instrument makers, pharmaceutical companies, clinical practitioners, and leading academic research groups in analytical sciences and engineering. In addition to the technical objectives, the CBM will also: (a) enable technology and knowledge transfer to the industrial sector, (b) enhance graduate and undergraduate education activities specifically designed to increase diversity of the STEM workforce, and (c) provide valuable updates to chemistry, biology, computer science, and engineering curricula through the incorporation of research into existing undergraduate and graduate classes.

这项建议需要规划一个生物分析计量学的产学研合作研究中心，这是圣母大学、印第安纳州大学和普渡大学的共同努力。规划活动将汇集分析仪器制造商，制药公司，临床医生，学术研究人员和其他利益相关者的国家联盟，并将他们团结在一个使命中，设计和建立新的，行业关键的化学测量和生物分析系统。需要这些系统来解决美国研究和开发中的一个根本性差距，即完全识别、表征和跟踪人体细胞内生物分子并了解其许多复杂相互作用的能力。如果成立，该中心的技术衍生产品将为药物发现，分子诊断，临床生物技术和其他领域带来直接和切实的利益。此外，该中心所设想的能力对于实现其他长期目标是必要的，例如精准医学。除了这种知识转移，该中心还将帮助培训新的和多样化的生物分析工作人员。规划工作的结果将构成向国家科学基金会提出的建立生物分析计量中心的建议的基础。基因组学、蛋白质组学、代谢组学和生物信息学为研究生物系统提供了一个整体框架，其应用范围从生物系统的基础研究到个性化医疗的诊断和治疗的设计和使用。然而，为了实现这些技术的承诺，我们必须增加对蛋白质、代谢物和其他生物分子物种的分析深度，使其超过目前的限制，从而减少被检测到但未被识别的物种的比例，这些物种统称为？生命的暗分子这项计划拨款为生物分析计量中心（CBM）奠定了基础，加入了印第安纳州圣母院和普渡大学的专业知识。规划活动将汇集分析仪器制造商，制药公司，临床医生和分析科学和工程领域的领先学术研究团体。除了技术目标外，CBM还将：（a）使技术和知识转移到工业部门，（B）加强专门为增加STEM劳动力多样性而设计的研究生和本科生教育活动，以及（c）通过将研究纳入现有的本科生和研究生课程，为化学，生物学，计算机科学和工程课程提供有价值的更新。