Planning Grant: Industry University Cooperative Research Center (IUCRC) for Bioanalytic Metrology (CBM), University of Notre Dame

规划资助：圣母大学生物分析计量学产学合作研究中心（IUCRC）

• 批准号: 1747764
• 负责人: Paul Bohn
• 金额: $ 1.5万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1747764&HistoricalAwards=false
• 关键词: Planning; Grant; Industry; University; Cooperative

This proposal entails planning for an Industry-University Collaborative Research Center for Bioanalytic Metrology, a joint effort of the University of Notre Dame, Indiana University, and Purdue University. Planning activities will bring together a national coalition of analytical instrument makers, pharmaceutical companies, clinical practitioners, academic researchers, and other stakeholders, and unite them in a mission to design and build new, industry-critical systems for chemical measurement and bioanalysis. These systems are needed to address a fundamental gap in U.S. research and development; namely, the ability to fully identify, characterize, and track biological molecules within human cells and understand their many complex interactions. If established, the technical spin-offs from the center will have direct and tangible benefits for drug discovery, molecular diagnostics, clinical biotechnology, and other areas. Moreover, the capabilities envisioned by the center are necessary for the implementation of other long-term objectives, such as precision medicine. In addition to this knowledge transfer, the center will also help train a new and diverse bioanalytical workforce. The outcomes of the planning exercise will form the basis of a proposal to the National Science Foundation to establish a Center for Bioanalytic Metrology. Genomics, proteomics, metabolomics and bioinformatics provide a holistic framework to study biological systems with applications ranging from fundamental studies of biological systems to the design and use of diagnostics and therapeutics for personalized medicine. To realize the promise of these technologies, however, we must increase the depth of analysis of proteins, metabolites and other biomolecular species beyond current limits, thus reducing the fraction of detected, but unidentified, species collectively known as the ?dark molecules of life.' This planning grant lays the groundwork for a Center for Bioanalytic Metrology (CBM), joining expertise at Notre Dame, Indiana, and Purdue. Planning activities will bring together analytical instrument makers, pharmaceutical companies, clinical practitioners, and leading academic research groups in analytical sciences and engineering. In addition to the technical objectives, the CBM will also: (a) enable technology and knowledge transfer to the industrial sector, (b) enhance graduate and undergraduate education activities specifically designed to increase diversity of the STEM workforce, and (c) provide valuable updates to chemistry, biology, computer science, and engineering curricula through the incorporation of research into existing undergraduate and graduate classes.

该提案需要为业界 - 大学生物分析计量学研究中心，圣母大学，印第安纳大学和普渡大学的共同努力计划。计划活动将汇集一个由分析仪器制造商，制药公司，临床从业人员，学术研究人员和其他利益相关者组成的国家联盟，并将其团结起来，以设计和建立新的，行业关键的化学测量和生物分析系统。需要这些系统来解决美国研发中的根本差距；也就是说，能够充分识别，表征和跟踪人类细胞中生物分子并了解其许多复杂相互作用的能力。如果建立，该中心的技术衍生产品将对药物发现，分子诊断，临床生物技术和其他领域具有直接和切实的好处。此外，中心设想的能力对于实施其他长期目标（例如精密医学）是必要的。除了这种知识转移之外，该中心还将帮助培训一支新的生物分析劳动力。计划练习的结果将构成建立生物分析计量中心的国家科学基金会提案的基础。基因组学，蛋白质组学，代谢组学和生物信息学提供了一个整体框架，可以研究生物系统，其应用从生物系统的基本研究到设计和使用个性化医学。但是，要实现这些技术的承诺，我们必须增加蛋白质，代谢产物和其他生物分子物种的分析深度，从而超出了当前限制，从而减少了被检测到的，但身份不明的物种的比例，统称为“黑暗生命的深色分子”。这项计划赠款为生物分析计量中心（CBM）奠定了基础，加入了巴黎圣母院，印第安纳州和普渡大学的专业知识。计划活动将汇集分析仪器制造商，制药公司，临床从业人员以及分析科学和工程领域领先的学术研究小组。除了技术目标外，CBM还将：（a）启用技术和知识转移到工业领域，（b）增强专门旨在提高STEM劳动力多样性的研究生和大学教育活动，以及（c）通过将研究成立于现有研究生和研究生级的研究，为化学，生物学，计算机科学和工程结构纳入化学，生物学，计算机科学和工程学。