Planning Grant: Industry University Cooperative Research Center (IUCRC) for Bioanalytic Metrology (CBM), University of Notre Dame

这项提案需要规划一个生物分析计量的产学研合作研究中心，由圣母大学、印第安纳大学和普渡大学共同努力。规划活动将汇集分析仪器制造商、制药公司、临床从业者、学术研究人员和其他利益相关者的全国联盟，并将他们联合起来，共同设计和建立新的化学测量和生物分析行业关键系统。需要这些系统来解决美国研发方面的根本差距；也就是说，能够完全识别、表征和跟踪人类细胞内的生物分子，并了解它们之间许多复杂的相互作用。如果成立，该中心的技术衍生品将为药物发现、分子诊断、临床生物技术和其他领域带来直接和切实的好处。此外，该中心设想的能力对于实现其他长期目标（如精准医疗）是必要的。除了这种知识转移之外，该中心还将帮助培训一支新的、多样化的生物分析队伍。规划工作的结果将成为向美国国家科学基金会提议建立生物分析计量学中心的基础。基因组学、蛋白质组学、代谢组学和生物信息学为研究生物系统提供了一个整体框架，其应用范围从生物系统的基础研究到个性化医疗的诊断和治疗的设计和使用。然而，为了实现这些技术的前景，我们必须增加对蛋白质、代谢物和其他生物分子物种的分析深度，以超越目前的限制，从而减少已检测到但未识别的物种的比例，这些物种统称为？黑暗的生命分子。”这项计划拨款为生物分析计量学中心（CBM）奠定了基础，该中心将联合印第安纳州圣母大学和普渡大学的专家。计划活动将把分析仪器制造商、制药公司、临床从业者和分析科学和工程领域的领先学术研究团体聚集在一起。除了技术目标外，CBM还将：(a)使技术和知识转移到工业部门，(b)加强专门旨在增加STEM劳动力多样性的研究生和本科教育活动，以及(c)通过将研究纳入现有的本科和研究生课程，为化学，生物，计算机科学和工程课程提供有价值的更新。

This proposal entails planning for an Industry-University Collaborative Research Center for Bioanalytic Metrology, a joint effort of the University of Notre Dame, Indiana University, and Purdue University. Planning activities will bring together a national coalition of analytical instrument makers, pharmaceutical companies, clinical practitioners, academic researchers, and other stakeholders, and unite them in a mission to design and build new, industry-critical systems for chemical measurement and bioanalysis. These systems are needed to address a fundamental gap in U.S. research and development; namely, the ability to fully identify, characterize, and track biological molecules within human cells and understand their many complex interactions. If established, the technical spin-offs from the center will have direct and tangible benefits for drug discovery, molecular diagnostics, clinical biotechnology, and other areas. Moreover, the capabilities envisioned by the center are necessary for the implementation of other long-term objectives, such as precision medicine. In addition to this knowledge transfer, the center will also help train a new and diverse bioanalytical workforce. The outcomes of the planning exercise will form the basis of a proposal to the National Science Foundation to establish a Center for Bioanalytic Metrology. Genomics, proteomics, metabolomics and bioinformatics provide a holistic framework to study biological systems with applications ranging from fundamental studies of biological systems to the design and use of diagnostics and therapeutics for personalized medicine. To realize the promise of these technologies, however, we must increase the depth of analysis of proteins, metabolites and other biomolecular species beyond current limits, thus reducing the fraction of detected, but unidentified, species collectively known as the ?dark molecules of life.' This planning grant lays the groundwork for a Center for Bioanalytic Metrology (CBM), joining expertise at Notre Dame, Indiana, and Purdue. Planning activities will bring together analytical instrument makers, pharmaceutical companies, clinical practitioners, and leading academic research groups in analytical sciences and engineering. In addition to the technical objectives, the CBM will also: (a) enable technology and knowledge transfer to the industrial sector, (b) enhance graduate and undergraduate education activities specifically designed to increase diversity of the STEM workforce, and (c) provide valuable updates to chemistry, biology, computer science, and engineering curricula through the incorporation of research into existing undergraduate and graduate classes.