Planning Grant: Industry University Cooperative Research Center (IUCRC) for Bioanalytic Metrology (CBM), Purdue University

这项拟议的活动将开展组织活动，启动一个新的工业-大学生物分析计量学合作研究中心，这是圣母大学、印第安纳大学和普渡大学的联合努力。这一努力将把分析仪器制造商、制药公司、临床从业者、学术研究人员和其他利益相关者组成一个全国性的联盟，并将他们团结在一起，为化学测量和生物分析设计和建造新的、行业关键的系统。需要这些系统来解决美国研究和开发中的一个根本差距，即完全识别、表征、跟踪和模拟人类细胞内生物分子的反应能力。如果成立，从该中心剥离出来的技术将对药物发现、分子诊断、临床生物技术和基础生物化学产生直接和切实的好处。此外，该中心设想的能力对于实施其他长期科学目标也是必要的，例如精确医学。除了这一知识转移，该中心还将帮助培训一支新的和多样化的生物分析工作队伍。规划工作的结果将成为向国家科学基金会提出建立生物分析计量中心(CBM)的建议的基础。基因组学、蛋白质组学、代谢组学和生物信息学为研究生物系统提供了一个整体框架，其应用范围从生物系统的基础研究到个性化医学的诊断和治疗的设计和使用。然而，为了实现这些技术的前景，我们必须增加对蛋白质、代谢物和其他生物分子物种的分析深度，超过目前的限制，从而减少已检测到的、但未识别的被称为生命黑暗分子的物种的比例。这笔规划拨款为CBM奠定了基础，加入了印第安纳州圣母院和普渡大学的专业知识。规划活动将汇集分析仪器制造商、制药公司、临床从业者以及分析科学和工程领域的领先学术研究团体。除了技术目标之外，CBM还将：i)促进技术和知识向工业部门的转移；ii)加强专门为增加STEM劳动力多样性而设计的研究生和本科教育活动；以及iii)通过将研究纳入现有的本科和研究生课程，提供有价值的更新化学、生物、计算机科学和工程课程。

This proposed activity will undertake organizing activities to launch a new Industry-University Collaborative Research Center for Bioanalytic Metrology, a joint effort of the University of Notre Dame, Indiana University, and Purdue University. The effort will bring together a national coalition of analytical instrument makers, pharmaceutical companies, clinical practitioners, academic researchers, and other stakeholders, and unite them in a mission to design and build new, industry-critical systems for chemical measurement and bioanalysis. These systems are needed to address a fundamental gap in U.S. research and development; namely, the ability to fully identify, characterize, track, and model reactivity of biological molecules within human cells. If established, the technical spin-offs from the center will have direct and tangible benefits for drug discovery, molecular diagnostics, clinical biotechnology, and fundamental biochemistry. Moreover, the capabilities envisioned by the center are necessary for the implementation of other long-term scientific objectives, such as precision medicine. In addition to this knowledge transfer, the center will also help train a new and diverse bioanalytical workforce. The outcomes of the planning exercise will form the basis of a proposal to the National Science Foundation to establish the Center for Bioanalytic Metrology (CBM). Genomics, proteomics, metabolomics and bioinformatics provide a holistic framework to study biological systems with applications ranging from fundamental studies of biological systems to the design and use of diagnostics and therapeutics for personalized medicine. To realize the promise of these technologies, however, we must increase the depth of analysis of proteins, metabolites and other biomolecular species beyond current limits, thus reducing the fraction of detected?but unidentified?species known as the ?dark molecules of life.? This planning grant lays the groundwork for the CBM, joining expertise at Notre Dame, Indiana, and Purdue. Planning activities will bring together analytical instrument makers, pharmaceutical companies, clinical practitioners, and leading academic research groups in analytical sciences and engineering. In addition to the technical objectives, the CBM will also: i) enable technology and knowledge transfer to the industrial sector, ii) enhance graduate and undergraduate education activities specifically designed to increase diversity of the STEM workforce, and iii) provide valuable updates to chemistry, biology, computer science, and engineering curricula through the incorporation of research into existing undergraduate and graduate classes.