Phase I IUCRC at Notre Dame: Center for Bioanalytic Metrology

生物分析计量中心(CBM)是圣母大学、印第安纳大学和普渡大学的合作伙伴关系，通过与业界合作解决当前、新兴和与行业相关的测量科学和技术挑战，提高美国的竞争力。该中心有两个总体目标：(1)提供一流的分子测量工具和专业知识，使制药、生物技术、食品/营养/农业、能源和分析仪器领域能够开发强大的竞争前新技术和能力；以及(2)成为将新仪器应用于尖端化学和生化问题的试验场。测量科学和相关仪器是美国经济的关键贡献者，推动了从药物发现到材料制造的方方面面的进步。通过将这些高科技行业的公司与主要的分析仪器制造商聚集在一起，CBM弥合了通过学术界和工业界合作产生的新想法的初步演示与能够推动技术发展的实用竞争前知识的交付之间的差距。同样重要的是，CBM为美国行业提供了令人信服的机会，通过接触各种中心培训的学生和现有员工的继续教育机会来振兴人力资源。CBM致力于推进生物分析测量科学，并将这些进展应用于解决小分子药物或农用化学品开发和交付、食品分析、生物衍生石化和/或生物燃料以及生物材料分析方面的挑战。CBM为工业伙伴提供下列方面的研究解决方案：(A)痕量生物标志物和杂质的超高灵敏度分析；(B)大生物分子及其多分子复合体之间的区别；(C)以高通量和生产率减少体积/材料分析和实验；(D)稀有/极稀薄细胞/分子/外切体等的分析；(E)大规模并行的化学细胞术、遗传图谱和小组筛选方法；(F)在线和近线现场测量；(G)使用点分析、配对诊断和现场廉价测试；(H)人工智能驱动的仪器、反馈优化和“无人驾驶”仪器；和(I)细胞、生物体和化学过程的增强成像。巴黎圣母院在蛋白质组学和代谢组学、使用点诊断、多模式化学成像、复杂生物流体的分离和分析、微生物行为的分子水平表征、增强的振动光谱、离子束衍生材料表征以及纳米材料和设备在化学分析中的应用方面贡献了独特的专业知识。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff. The CBM is devoted to advancing bioanalytical measurement science and applying these advances to address challenges in small molecule pharmaceuticals or agrochemicals development and delivery, in the analysis of foods, in biologically derived petrochemicals and/or biofuels, and in biological materials analysis. The CBM serves the industrial partners with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and "driverless" instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Notre Dame contributes distinctive expertise in proteomics and metabolomics, point-of-use diagnostics, multimodal chemical imaging, separations and analyses of complex biofluids, molecular-level characterization of microbial behavior, enhanced vibrational spectroscopies, ion-beam derived materials characterization, and application of nanomaterials and devices to chemical analysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.