Untangling the Development and Use of Infrastructures in the Production of Knowledge about Genetics, Blood, and Race
理清基因、血液和种族知识生产中基础设施的开发和使用
基本信息
- 批准号:1755003
- 负责人:
- 金额:$ 18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-01 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project uses social scientific knowledge about the complexities of notions of race and notions of population differences to examine how biomedical researchers and medical professionals use race in their research and therapeutic infrastructures and practices. It also examines the effects of the organization of these infrastructures by racial categories in the subsequent production of knowledge about genetics, blood, and race. For example, the organization of blood infrastructures has consequences for bone marrow transplantation and stem cell research and therapeutics. This project will provide knowledge that will assist life scientists and medical faculty with their research and with a potential reorganization of research and therapeutic infrastructures. The project will also provide knowledge to supplement ongoing research and training of Ph.D. students in the social sciences, bioethics, and life sciences, and to medical and pharmacy students. The research will contribute to a book designed to present social studies of infrastructures, standards, race, genetics, and blood to a broad readership, including undergraduate students in relevant humanities, social sciences, life and medical sciences. This project will shed light on difficult ethical and political questions that arise as researchers carry out research on genetic and biological differences amongst human groups, especially when it involves racial and ethnic differences that already divide this country. The current project examines the use of racial and ethnic categories by researchers who work with blood banks and bone marrow registries, as well as with genetic markers and diets. It engages two major topics in science and technology studies. First, it will contribute to social scientific scholarship on infrastructures and standards in science. Infrastructure is a term that includes the databases, algorithms, models and practices used in scientific research. This study of scientific infrastructures also includes an analysis of policy decisions about which infrastructures to build and how to organize them; the laboratory practices, instruments, and decisions that create and structure the data in infrastructures; and the analytic processes through which data in infrastructures are used. Second, the project examines whether and how social assumptions and ideas about race and ethnicity become part of research and therapeutic infrastructures, practices, and outcomes. This focus on race categories is part of an ongoing set of studies that has raised questions about the use of race categories in genomic and biomedical research. The project introduces the study of the rationale for and impact of a newly instituted category of "multiracials" into blood infrastructures. The research sites include cord blood banks and bone marrow registries in large, racially diverse city, which are currently organized by race and multiracial categories. The findings from these sites will be compared with similar infrastructures in a similarly diverse city in another state. The findings about these blood infrastructures will then be compared with the PI's previous findings from genomic biomarker research conducted in a project that was based in these two cities. Research data gathering methods include ethnographic observation, interviews and documentary reviews, and data analysis based on the "grounded theory" method.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该项目利用有关种族概念和人口差异概念的复杂性的社会科学知识,研究生物医学研究人员和医疗专业人员如何在其研究和治疗基础设施和实践中使用种族。它还研究了这些基础设施的组织在随后的生产知识的遗传学,血液和种族的种族类别的影响。例如,血液基础设施的组织对骨髓移植和干细胞研究和治疗有影响。该项目将提供知识,帮助生命科学家和医学教师进行研究,并可能重组研究和治疗基础设施。该项目还将提供知识,以补充正在进行的研究和博士培训。社会科学、生物伦理学和生命科学专业的学生以及医学和药学专业的学生。这项研究将有助于一本书,旨在介绍基础设施,标准,种族,遗传学和血液的社会研究,以广泛的读者群,包括相关的人文,社会科学,生命和医学科学的本科生。该项目将阐明研究人员对人类群体之间的遗传和生物差异进行研究时出现的困难的伦理和政治问题,特别是当它涉及已经分裂这个国家的种族和民族差异时。目前的项目检查了研究人员使用的种族和民族类别,这些研究人员与血库和骨髓登记处以及遗传标记和饮食有关。它涉及科学和技术研究的两个主要课题。 首先,它将有助于社会科学的基础设施和科学标准的奖学金。 基础设施是一个术语,包括科学研究中使用的数据库,算法,模型和实践。 科学基础设施的这项研究还包括有关建立哪些基础设施以及如何组织它们的政策决策的分析;创建和构建基础设施中数据的实验室实践,仪器和决策;以及基础设施中数据使用的分析过程。其次,该项目研究是否以及如何社会假设和种族和民族的想法成为研究和治疗基础设施,实践和成果的一部分。 这种对种族类别的关注是正在进行的一系列研究的一部分,这些研究提出了关于在基因组和生物医学研究中使用种族类别的问题。 该项目介绍了对血液基础设施中新设立的“多种族”类别的基本原理和影响的研究。研究地点包括在种族多样化的大城市中的脐带血库和骨髓登记处,这些地方目前是按种族和多种族分类组织的。 这些网站的调查结果将与另一个州类似多样化城市的类似基础设施进行比较。然后将这些血液基础设施的发现与PI先前在这两个城市进行的基因组生物标志物研究的发现进行比较。 研究数据收集方法包括民族志观察、访谈和文献综述,以及基于“扎根理论”方法的数据分析。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Variations on a Chip: Technologies of Difference in Human Genetics Research
- DOI:10.1007/s10739-018-9543-x
- 发表时间:2018-10
- 期刊:
- 影响因子:0.8
- 作者:R. Rajagopalan;J. H. Fujimura
- 通讯作者:R. Rajagopalan;J. H. Fujimura
Staying the Course: On the Value of Social Studies of Science in Resistance to the “Post-Truth” Movement
坚持到底:论科学社会研究在抵抗“后真相”运动中的价值
- DOI:10.1111/socf.12545
- 发表时间:2019
- 期刊:
- 影响因子:1.8
- 作者:Fujimura, Joan H;Holmes, Christopher J.
- 通讯作者:Holmes, Christopher J.
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Joan Fujimura其他文献
Joan Fujimura的其他文献
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{{ truncateString('Joan Fujimura', 18)}}的其他基金
Doctoral Dissertation Research: Reproducing Difference in Biomedicine: The Case of Sex as a Biological Variable
博士论文研究:再现生物医学的差异:性别作为生物变量的案例
- 批准号:
1849234 - 财政年份:2019
- 资助金额:
$ 18万 - 项目类别:
Standard Grant
Knowledge Outputs and Organizational Changes: Innovation in Collaborative Scientific Research
知识输出和组织变革:协作科学研究的创新
- 批准号:
1360241 - 财政年份:2014
- 资助金额:
$ 18万 - 项目类别:
Standard Grant
Dissertation Research: Doing Nanotechnology in the 21st Century Postsocialist China: Local Worlds and Alternative Modernities
论文研究:21世纪后社会主义中国的纳米技术:本土世界和另类现代性
- 批准号:
0621150 - 财政年份:2006
- 资助金额:
$ 18万 - 项目类别:
Standard Grant
Exploring Concepts of Population in Human Genetic Variation Studies
探索人类遗传变异研究中的群体概念
- 批准号:
0621022 - 财政年份:2006
- 资助金额:
$ 18万 - 项目类别:
Standard Grant
Dissertation Research: Reconfiguring Traditional Chinese Medicine: A Comparative Transnational Study in China and the United States
论文研究:重构中医:中美跨国比较研究
- 批准号:
9806946 - 财政年份:1998
- 资助金额:
$ 18万 - 项目类别:
Standard Grant
U.S.-Australian Joint Seminar: Gender, Science, and Technology; Melbourne, Australia; June 1993
美国-澳大利亚联合研讨会:性别、科学与技术;
- 批准号:
9215692 - 财政年份:1993
- 资助金额:
$ 18万 - 项目类别:
Standard Grant
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