Influence of Mesh Size, Type of Crosslinking, Polymer Stiffness and Interfacial Rheology on the Frictional Characteristics of Hydrogels

网格尺寸、交联类型、聚合物刚度和界面流变性对水凝胶摩擦特性的影响

• 批准号: 1761696
• 负责人: Rosa Espinosa-Marzal
• 金额: $ 37.58万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1761696&HistoricalAwards=false
• 关键词: Influence; Mesh; Size; Type; Crosslinking

This grant will support research that will advance the knowledge related to a structure-property relation for hydrogels, promoting both the progress of science and advancing national health. Hydrogels are a class of soft materials, composed of crosslinked polymeric networks that remarkably swell in water, which closely simulate many natural biological tissues, like mucous gel layers. Biological lubrication taking place in respiratory and gastrointestinal tracts, in the oral cavity and in the eyes, relies on the low friction coefficients provided by these mucous gel layers. Despite significant research effort, there is still disagreement about the origin of such low friction, which hinders the design of biomaterials capable of achieving efficient biolubrication to date. This project will thus deliver the needed knowledge of the relation between hydrogel's properties and frictional response. Thereby, it will enable to establish design principles of hydrogels for targeted biomedical applications capable of achieving low friction coefficients, and augmented wear resistance, and therefore, results from this research will benefit the U.S. society. This research involves several disciplines including materials chemistry and science, and tribology. The multi-disciplinary approach will help broaden participation of underrepresented groups in research and positively impact engineering education.In order to fill the outlined knowledge gap, two major lines of research will be followed: one comparing physically and chemically crosslinked hydrogels with a wide range of crosslinking degrees, and a second one that will study the influence of polymer chain semi-flexibility. To evaluate lubrication mechanisms, friction force measurements will be carried out on well-characterized hydrogels (with a wide range of compositions) by colloidal probe Atomic Force Microscopy and with a Surface Forces Apparatus as a function of load and sliding velocity (spanning over five orders of magnitude) to probe microscopic phenomena with different relaxation times. The experimental effort will provide insight into the effects of mesh size, type of crosslinking, polymer stiffness, as well as aging of the interface, on the frictional characteristics. The research team will also conduct dynamic shear-force measurements to scrutinize the relation between friction force and interfacial rheology of hydrogels. The knowledge generated by this research will afford to modulate the frictional response of hydrogels through the precise control of their microstructure.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该补助金将支持将推进与水凝胶结构-性质关系相关的知识的研究，促进科学进步和促进国民健康。水凝胶是一类软质材料，由交联聚合物网络组成，在水中显着溶胀，其紧密模拟许多天然生物组织，如粘液凝胶层。在呼吸道和胃肠道、口腔和眼睛中发生的生物润滑依赖于这些粘液凝胶层提供的低摩擦系数。尽管进行了大量的研究工作，但对于这种低摩擦的起源仍然存在分歧，这阻碍了迄今为止能够实现有效生物润滑的生物材料的设计。因此，该项目将提供所需的水凝胶的性质和摩擦响应之间的关系的知识。因此，它将能够建立用于目标生物医学应用的水凝胶的设计原则，能够实现低摩擦系数和增强的耐磨性，因此，这项研究的结果将有利于美国社会。本研究涉及材料化学与材料科学、摩擦学等多个学科。多学科方法将有助于扩大代表性不足的群体在研究中的参与，并对工程教育产生积极影响。为了填补上述知识空白，将遵循两条主要研究路线：一条是比较具有广泛交联度的物理和化学交联水凝胶，另一条是研究聚合物链半柔性的影响。为了评估润滑机制，将通过胶体探针原子力显微镜和表面力装置对充分表征的水凝胶（具有广泛的组成）进行摩擦力测量，作为负载和滑动速度（跨越五个数量级）的函数，以探测具有不同弛豫时间的微观现象。实验的努力将提供深入了解网格尺寸，交联类型，聚合物刚度，以及老化的接口，对摩擦特性的影响。研究小组还将进行动态剪切力测量，以仔细研究摩擦力和水凝胶界面流变学之间的关系。这项研究产生的知识将通过精确控制水凝胶的微观结构来调节其摩擦响应。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Insight into the Viscous and Adhesive Contributions to Hydrogel Friction

深入了解粘性和粘合剂对水凝胶摩擦的贡献

• DOI: 10.1007/s11249-018-1045-7
• 发表时间: 2018
• 期刊: Tribology Letters
• 影响因子: 3.2
• 作者: Shoaib, Tooba;Espinosa-Marzal, Rosa M.
• 通讯作者: Espinosa-Marzal, Rosa M.

Transient stiffening of cartilage during joint articulation: A microindentation study

关节连接过程中软骨的瞬时硬化：微压痕研究

• DOI: 10.1016/j.jmbbm.2020.104113
• 发表时间: 2021
• 期刊: Journal of the Mechanical Behavior of Biomedical Materials
• 影响因子: 3.9
• 作者: Yuh, Catherine;Laurent, Michel P.;Espinosa-Marzal, Rosa M.;Chubinskaya, Susan;Wimmer, Markus A.
• 通讯作者: Wimmer, Markus A.

Compositional Tuning Reveals a Pathway to Achieve a Strong and Lubricious Double Network in Agarose-Polyacrylamide Hydrogels

• DOI: 10.1007/s11249-022-01604-4
• 发表时间: 2022-05
• 期刊: Tribology Letters
• 影响因子: 3.2
• 作者: Tooba Shoaib;P. Prendergast;R. Espinosa‐Marzal

Advances in Understanding Hydrogel Lubrication

• DOI: 10.3390/colloids4040054
• 发表时间: 2020-11
• 期刊: Colloids and Interfaces
• 影响因子: 2.4
• 作者: Tooba Shoaib;R. Espinosa‐Marzal

Insight into the assembly of lipid-hyaluronan complexes in osteoarthritic conditions

深入了解骨关节炎条件下脂质-透明质酸复合物的组装

• DOI: 10.1116/6.0002502
• 发表时间: 2023
• 期刊: Biointerphases
• 影响因子: 2.1
• 作者: Sun, Kangdi;Shoaib, Tooba;Rutland, Mark W.;Beller, Joesph;Do, Changwoo;Espinosa-Marzal, Rosa M.
• 通讯作者: Espinosa-Marzal, Rosa M.