Molecularly selective sensors based on organic semiconductors and artificial receptors: demonstrations and scaling studies

基于有机半导体和人工受体的分子选择性传感器：演示和规模研究

• 批准号: 1804915
• 负责人: Alberto Salleo
• 金额: $ 30万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1804915&HistoricalAwards=false
• 关键词: Molecularly; selective; sensors; based; organic

A robust sensing technology, suitable for wearable devices, will be developed for continuous monitoring of molecules secreted by the human body. Electrically active polymers will be combined with molecularly selective polymers to sense a range of molecules in a sensitive and selective way. The sensor fabrication process will take advantage of the same technology developed to fabricate microprocessors, thus giving access to a wide range of sensor sizes and shapes in order to determine the optimum sensor geometry. Furthermore, the electrical response of the sensor will be modeled mathematically in order to predict the best sensor design. Finally, several sensors will be arrayed to demonstrate the simultaneous detection of several molecules of interest. The development of a general sensing technology based on plastics has the potential to produce a substantial impact in the world of low-cost wearable sensors suitable for non-hospital based applications. Furthermore, the workforce trained with these funds will have an interdisciplinary outlook, being equally comfortable with electronics and with biomedical applications in the realm of analytical chemistry.Enzyme-based sensing is not robust for wearables or measurements in non-controlled environments. A new transduction method is proposed where an organic electrochemical transistor (OECT) is functionalized with a robust molecularly imprinted polymer (MIP) incorporated in a membrane. The MIP acts as an artificial receptor and selectively binds to the molecule that was imprinted in it during the fabrication phase. This is an entirely new sensor device concept, which incorporates selectivity (from the membrane) and sensitivity (thanks to the gain given by the transistor). This approach works in a cortisol sensor, which is compatible with wearable electronics as it is sensitive (thanks to the electronic gain of the transistor), operates at low voltages and can be fabricated on flexible substrates. Device scaling studies will demonstrate that sensitivity and range can be controlled with device geometry. The effect of processing on the selectivity and sensitivity of the membrane will be studied as well. Ultimately these experimental data will be used to build and validate a complete device model, which will give insights into the device physics of the sensor and will be used for a priori design of sensors with arbitrary architectures. Because the concept of OECT and artificial receptor membranes is general, the model will be a useful design tool for this entire family of novel sensors.Finally, the MIP-functionalization approach is quite general as will be demonstrated by building a multiplexed sensor array that will sense two hormones (cortisol and adrenaline) in addition to other electrolytes in a single sample. A high-school teacher will be involved in the project with the goal of using the materials investigated to fabricate a ?visible? transistor, i.e. a device where the switching process can be viewed by naked eye. The goal is to provide a simple demonstration for high-school students helping them understand the basic functionality of the device that is at the heart of the IT revolution.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

将开发适用于可穿戴设备的强大传感技术，用于连续监测人体分泌的分子。电活性聚合物将与分子选择性聚合物结合，以敏感和选择性的方式感测一系列分子。传感器制造过程将利用与制造微处理器相同的技术，从而获得广泛的传感器尺寸和形状，以确定最佳的传感器几何形状。此外，传感器的电响应将被数学建模，以预测最佳传感器设计。最后，几个传感器将被排列，以证明同时检测几个感兴趣的分子。基于塑料的通用传感技术的发展有可能在适用于非医院应用的低成本可穿戴传感器领域产生重大影响。此外，通过这些资金培训的员工将具有跨学科的视野，对分析化学领域的电子和生物医学应用同样熟悉。酶传感对于可穿戴设备或非受控环境中的测量来说并不强大。提出了一种新的转导方法，其中有机电化学晶体管（OECT）的功能与强大的分子印迹聚合物（MIP）纳入膜。MIP充当人工受体，并选择性地结合在制造阶段期间印记在其中的分子。这是一个全新的传感器器件概念，它结合了选择性（来自膜）和灵敏度（由于晶体管提供的增益）。这种方法适用于皮质醇传感器，该传感器与可穿戴电子产品兼容，因为它很敏感（由于晶体管的电子增益），在低电压下工作，并且可以在柔性基板上制造。器械缩放研究将证明灵敏度和范围可通过器械几何形状进行控制。同时还研究了膜的处理工艺对膜的选择性和灵敏度的影响。最终，这些实验数据将用于构建和验证完整的器件模型，该模型将深入了解传感器的器件物理特性，并将用于具有任意架构的传感器的先验设计。由于OECT和人工受体膜的概念是通用的，该模型将是一个有用的设计工具，这整个家庭的新型sensors.Finally，MIP功能化的方法是相当普遍的，将通过建立一个多路复用的传感器阵列，将感测两种激素（皮质醇和肾上腺素），除了在一个单一的样品中的其他电解质证明。一名高中教师将参与该项目的目标是使用调查的材料来制作一个？看得见的？晶体管，即开关过程可以用肉眼观察到的器件。其目的是为高中生提供一个简单的演示，帮助他们了解处于IT革命核心的设备的基本功能。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Redox-Active Polymers Designed for the Circular Economy of Energy Storage Devices

• DOI: 10.1021/acsenergylett.1c01625
• 发表时间: 2021-09
• 期刊: ACS Energy Letters
• 影响因子: 22
• 作者: Siew Ting Melissa Tan;T. Quill;Maximilian Moser;G. LeCroy;Xingxing Chen;Yilei Wu;Christopher J Takacs;Alberto Salleo;Alexander Giovannitti

High‐Gain Chemically Gated Organic Electrochemical Transistor

• DOI: 10.1002/adfm.202010868
• 发表时间: 2021-03
• 期刊: Advanced Functional Materials
• 影响因子: 19
• 作者: S. T. M. Tan;Alexander Giovannitti;A. Melianas;Maximilian Moser;Benjamin L. Cotts;Devan Singh;I. McCulloch-I

Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration

• DOI: 10.1002/adhm.201901321
• 发表时间: 2019-11-12
• 期刊: ADVANCED HEALTHCARE MATERIALS
• 影响因子: 10
• 作者: Keene, Scott T.;Fogarty, Daragh;Parlak, Onur
• 通讯作者: Parlak, Onur

Operation mechanism of organic electrochemical transistors as redox chemical transducers

有机电化学晶体管作为氧化还原化学传感器的工作机制

• DOI: 10.1039/d1tc02224e
• 发表时间: 2021
• 期刊: Journal of Materials Chemistry C
• 影响因子: 6.4
• 作者: Tan, Siew Ting;Keene, Scott;Giovannitti, Alexander;Melianas, Armantas;Moser, Maximilian;McCulloch, Iain;Salleo, Alberto
• 通讯作者: Salleo, Alberto