I-Corps: Laser-Biomaterial Interaction Based Prototyping Platform

I-Corps：基于激光-生物材料交互的原型平台

• 批准号: 1806198
• 负责人: Douglas Chrisey
• 金额: $ 5万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1806198&HistoricalAwards=false
• 关键词: Corps; Laser; Biomaterial; Interaction; Based

The broader impact/commercial potential of this I-Corps project will be to provide a fabrication system to companies manufacturing and/or developing cell based models for sale and/or service, pharmaceutical companies, and research organizations. The platform will allow these entities to prototype and scale quicker, fail faster, and reduce costs of commercialization. Companies often must completely reengineer their fabrication process when scaling or changing their models. With this system, they can more rapidly iterate through potential designs. Decreasing the time to develop new cell based models will benefit the public and companies in this important and growing field. In addition, the technology can have an impact in analyzing/ranking potential drug candidates for pharmaceutical companies.This I-Corps project is based on techniques used to rapidly prototype inorganic metallic electronics commonly called laser induced forward transfer. The system integrates laser direct write and laser micromachining (additive and subtractive techniques, respectively) for the manipulation and prototyping of biomaterials on a micron scale. Cells/biomaterials can be precisely transferred to a substrate using laser-assisted direct write. Before and/or after the transfer of 1-1000's of cells/units, the substrates can be shaped using laser ablation to create cell-scale geometries. Alternating addition and subtraction of (bio)materials in a controlled and repeatable way on a micron scale allows for the creation of cellular constructs in almost any geometry and gradient of chemical factors. A goal of this I-Corps project is to determine the commercial potential for the technology as a platform and/or as a service.

该I-Corps项目的更广泛的影响/商业潜力将是为制造和/或开发用于销售和/或服务的基于细胞的模型的公司、制药公司和研究组织提供制造系统。 该平台将允许这些实体更快地进行原型设计和扩展，更快地失败，并降低商业化成本。公司在缩放或更改模型时通常必须完全重新设计其制造过程。有了这个系统，他们可以更快地通过潜在的设计。减少开发新的基于细胞的模型的时间将有利于这个重要和不断增长的领域的公众和公司。此外，该技术可以在分析/排名潜在的候选药物的制药公司的影响。这个I-Corps项目是基于用于快速原型无机金属电子通常称为激光诱导前向转移的技术。 该系统集成了激光直写和激光微加工（分别为加法和减法技术），用于在微米尺度上对生物材料进行操作和原型制作。细胞/生物材料可以使用激光辅助直接写入精确地转移到基底上。在转移1-1000个细胞/单位之前和/或之后，可以使用激光烧蚀使基底成形以产生细胞级几何形状。在微米尺度上以受控和可重复的方式交替添加和减去（生物）材料允许以几乎任何几何形状和化学因子梯度创建细胞构建体。这个I-Corps项目的目标是确定该技术作为平台和/或服务的商业潜力。