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MRI: Acquisition of a versatile, user-friendly, automated fluorescence microscope to promote research performed by faculty and undergraduates at a Hispanic-serving institution

MRI：购买多功能、用户友好的自动荧光显微镜，以促进西班牙裔服务机构的教师和本科生进行的研究

基本信息

批准号：
1826871
负责人：
Andrea Holgado
金额：
$ 20.73万
依托单位：
Saint Edward's University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-10-01 至 2021-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1826871&HistoricalAwards=false
关键词：
MRI Acquisition versatile user friendly

项目摘要

An award is made to St. Edward's University (SEU) to do state-of-the-art fluorescence microscopy as part of faculty-mentored research and course-based undergraduate research experiences (CUREs). SEU is a minority-serving institution with a diverse student body, many of whom are first-generation college students. Faculty-mentored research at SEU is usually their first exposure to novel scientific research. The acquisition of this microscope improves the research infrastructure by promoting the quality of faculty-sponsored independent research, increasing and enhancing the number of cell-molecular experiments performed as part of CUREs, and broadening the types of outreach programs involving Austin Community College students and K-12 teachers and students. Finally, this microscope will provide needed synergy with other current NSF-funded projects at SEU.Fluorescence microscopy allows the detection and analysis of molecular and cellular structures, molecular dynamics, and gene expression through a panoply of widely available fluorophore-conjugated molecules and genetically-encoded fluorescent proteins. This award facilitates the purchase of a microscope that is conducive to live imaging under controlled environments, high-sensitivity detection of faint fluorophores, optical sectioning of thick specimens, and 3D image acquisitions. The instrumentation enables the research of a highly diverse set of scientific programs at SEU: (1) Characterization of the interplay between cellular metabolic regulation and neurodevelopment in soil-dwelling nematodes, (2) Determination of the molecular mechanism underlying interactions between host cells and parasitic pathogens like those causing toxoplasmosis, (3) Understanding the molecular basis of variation for patterning of the egg shell in fruit flies, (4) Investigation of the bacterial targets of antimicrobial plant extracts and examination of the protective action of probiotics, and (5) Characterization of plant-fungal interactions in response to phosphate stress.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

圣爱德华大学(SEU)被授予从事最先进的荧光显微镜研究，作为教师指导的研究和基于课程的本科生研究经验(CURE)的一部分。SEU是一所为少数族裔服务的机构，学生群体多样化，其中许多是第一代大学生。在SEU教员指导的研究通常是他们第一次接触到新颖的科学研究。这台显微镜的购买改善了研究基础设施，提高了教职员工赞助的独立研究的质量，增加和加强了作为治疗一部分进行的细胞-分子实验的数量，并扩大了涉及奥斯汀社区学院学生和K-12教师和学生的外联计划的类型。最后，这种显微镜将与目前由美国国家科学基金会资助的其他SEU项目提供必要的协同作用。荧光显微镜可以通过一系列广泛可用的荧光团结合分子和基因编码的荧光蛋白来检测和分析分子和细胞结构、分子动力学和基因表达。该合同有助于购买一种显微镜，用于受控环境下的实时成像、微弱荧光团的高灵敏度检测、厚样品的光学切片和3D图像采集。该仪器使SEU能够研究一套高度多样化的科学计划：(1)表征土壤线虫细胞代谢调节和神经发育之间的相互作用，(2)确定宿主细胞和引起弓形虫病的寄生病原体之间潜在的分子机制，(3)了解果蝇卵壳形成的分子基础，(4)调查抗菌植物提取物的细菌靶标和检查益生菌的保护作用，该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。