MRI: Acquisition of A Versatile High Resolution MS System for Determination of Small Molecules of Environmental and Health Concern

MRI：获取多功能高分辨率 MS 系统，用于测定环境和健康问题的小分子

• 批准号: 1428873
• 负责人: David Reckhow
• 金额: $ 45.5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1428873&HistoricalAwards=false
• 关键词: MRI; Acquisition; Versatile; Resolution; MS

PI: Reckhow, David A.Proposal: 1428873Title: MRI: Acquisition of A Versatile High Resolution MS System for Determination of Small Molecules of Environmental and Health ConcernSignificanceThis proposal is for the acquisition of a high resolution system for identifying and quantifying trace organic contaminants in water. The research group involved in this project has forged a strong link between environmental engineering and public health. Their proposed research projects have many applied objectives including potential translational benefits, such as discovery and then remediation of emerging contaminants in drinking water, and novel treatments for water and sanitation in Third World countries. The Xevo G2-S QTof is ideally suited for use by students from broad backgrounds due to its simple and intuitive interface. This instrument will be a centerpiece of an open resource (EEAP) available not only to those at UMass, but across the Northeast region. At UMass, it will serve the core researchers in Environmental Engineering, as well as an interdisciplinary group of researchers in various science disciplines and Public Health. Outside of UMass, it will be available for use by researchers in the 5-college consortium, and beyond, especially Universities and Colleges in New England and nearby states. Technical DescriptionThis proposal is for the acquisition of a high resolution system for identifying and quantifying trace organic contaminants in water. The Xevo G2-S QTof is a quadrupole time-of-flight instrument capable of rapidly switching between liquid (e.g., UPLC) and gas (e.g., GC) sources. This instrument will be a centerpiece of an open resource (EEAP) available not only to those at UMass, but across the Northeast region. This instrument will help connect engineering management and control technologies to the ultimate endpoints of public health. Examples include the role of watershed management and treatment technologies on bladder cancer caused by halobenzoqinones and related compounds in drinking water. Another touches upon the role of elevated bromide from industrial activities on cancer. A third pertains to nitrogenous organic compounds generated in surface waters from algal activity and photonitration reactions and human health endpoints. Others employ innovative mixed algal-bacterial granules to treat wastewater and produce biofuel, or bioelectrical systems to facilitate wastewater treatment in modern non-flush systems while producing electricity.

主要研究者：Reckhow，大卫A.建议：1428873职务：核磁共振成像：购买用于测定环境和健康小分子的多功能高分辨率MS系统重要性该提案旨在购买用于识别和量化水中痕量有机污染物的高分辨率系统。参与该项目的研究小组在环境工程和公共卫生之间建立了牢固的联系。他们提出的研究项目有许多应用目标，包括潜在的转化效益，如发现和修复饮用水中新出现的污染物，以及第三世界国家的水和卫生新处理方法。Xevo G2-S QTof由于其简单直观的界面，非常适合来自广泛背景的学生使用。该仪器将成为开放资源（EEAP）的核心，不仅适用于马萨诸塞大学，而且适用于整个东北地区。在马萨诸塞大学，它将服务于环境工程的核心研究人员，以及各种科学学科和公共卫生的跨学科研究人员。在马萨诸塞大学之外，它将可供5所大学联盟及其他地区的研究人员使用，特别是新英格兰和附近州的大学和学院。 技术说明本建议书是为获得一个高分辨率的系统，用于识别和量化水中的痕量有机污染物。Xevo G2-S QTof是一种四极飞行时间仪器，能够在液体（例如，UPLC）和气体（例如，GC）来源。该仪器将成为开放资源（EEAP）的核心，不仅适用于马萨诸塞大学，而且适用于整个东北地区。该工具将有助于将工程管理和控制技术与公共卫生的最终终点联系起来。实例包括流域管理和处理技术对饮用水中的卤代苯醌和相关化合物引起的膀胱癌的作用。另一个涉及到工业活动中溴化物升高对癌症的作用。第三个问题涉及表层沃茨中藻类活动和光硝化反应产生的含氮有机化合物以及人类健康终点。其他公司则采用创新的混合藻类-细菌颗粒来处理废水并生产生物燃料，或采用生物电系统来促进现代非冲洗系统中的废水处理，同时生产电力。