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MRI: Acquisition of a Single Crystal X-ray Diffractometer to Serve as a Regional Resource

MRI：购买单晶 X 射线衍射仪作为区域资源

基本信息

批准号：
1827313
负责人：
Kraig Wheeler
金额：
$ 32.5万
依托单位：
Whitworth University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827313&HistoricalAwards=false
关键词：
MRI Acquisition Single Crystal ray

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Kraig Wheeler from Whitworth University and colleagues Jamie Manson from Eastern Washington University, Matthew E Cremeens from Gonzaga University and Travis Denton from Eastern Washington University have acquired a single crystal diffractometer. An X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule. This includes bond distances and angles. This provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. In one project, the research targets molecules that may serve as quantum magnets. In a green chemistry approach, catalysts containing iron are being synthesized that can replace other less expensive metals. Chalcones, materials with biological activity beneficial for anti-inflammation, are being studied. The diffractometer is used in a collaborative network to train and to provide undergraduate and graduate students with the principles of crystallography. The following institutions are the main members of the network: Whitworth University, Gonzaga University, Eastern Illinois University, Oakland University, Knox College, Eastern Washington University, and Washington State University. The award is aimed at enhancing research and education at all levels. It especially impacts studies of molecular recognition profiles of quasiracemic materials. Medicinal-relevant chalcones are being investigated as well as the design of small organic molecules as possible pharmaceutical chaperones. The diffractometer is used in structure analyses of iron catalysts supported by alpha-diimine ligands. This instrument also serves projects developing near-infrared active materials. It is used in research to design small molecule inhibitors of cytochrome 450 2A6 that have potential for use in stopping smokingThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器项目和化学研究仪器项目支持。惠特沃斯大学的Kraig Wheeler教授和他的同事东华盛顿大学的Jamie Manson、Gonzaga大学的Matthew E Cremeens和东华盛顿大学的Travis Denton已经获得了单晶衍射仪。X射线衍射仪可以精确和精确地测量分子的全部三维结构。这包括连接距离和角度。这提供了关于一个分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响到许多领域，包括有机化学和无机化学、材料化学和生物化学。在一个项目中，这项研究的目标是可能起到量子磁铁作用的分子。在一种绿色化学方法中，人们正在合成含有铁的催化剂，以取代其他价格较低的金属。查尔酮是一种具有抗炎生物活性的材料，目前正在研究中。衍射仪在一个协作网络中用于培训和向本科生和研究生提供结晶学原理。以下机构是该网络的主要成员：惠特沃斯大学、冈萨加大学、东伊利诺伊大学、奥克兰大学、诺克斯学院、东华盛顿大学和华盛顿州大学。该奖项旨在加强各级的研究和教育。它尤其影响准外消旋材料的分子识别谱的研究。与药物相关的查尔酮以及作为可能的药物伴侣的小有机分子的设计正在进行研究。衍射仪用于α-二亚胺负载铁催化剂的结构分析。该仪器还服务于开发近红外活性材料的项目。它被用于研究设计有潜力用于戒烟的细胞色素450 2A6小分子抑制剂。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Molecular Recognition and Shape Studies of 3- and 4-Substituted Diarylamide Quasiracemates

DOI：
10.3390/cryst11121596
发表时间：
2021-12
期刊：
Crystals
影响因子：
2.7
作者：
Alicia Brandt;Derek J. Boyle;Jacob P. Butler;Abigail R. Gillingham;Scott E. Penner;Jacqueline M. Spaniol-Jacqueline-M
通讯作者：
Alicia Brandt;Derek J. Boyle;Jacob P. Butler;Abigail R. Gillingham;Scott E. Penner;Jacqueline M. Spaniol-Jacqueline-M

Enhancing easy-plane anisotropy in bespoke Ni(II) quantum magnets