MRI: Acquisition of a Single Crystal X-ray Diffractometer to Serve as a Regional Resource

该奖项由主要研究仪器和化学研究仪器项目支持。惠特沃斯大学的克莱格·惠勒教授和他的同事，东华盛顿大学的杰米·曼森、冈萨加大学的马修·E·克雷门斯以及东华盛顿大学的特拉维斯·丹顿，已经获得了一台单晶衍射仪。x射线衍射仪可以对分子的完整三维结构进行精确的测量。这包括键的距离和角度。这提供了一个分子相对于邻近分子的空间排列的准确信息。这里描述的研究影响许多领域，包括有机和无机化学，材料化学和生物化学。在其中一个项目中，研究的目标是可能用作量子磁体的分子。在一种绿色化学方法中，含有铁的催化剂正在被合成，可以取代其他较便宜的金属。查尔酮是一种具有抗炎生物活性的材料，目前正在研究中。衍射仪在一个协作网络中用于训练和提供本科生和研究生晶体学原理。以下机构是该网络的主要成员：惠特沃斯大学、冈萨加大学、东伊利诺伊大学、奥克兰大学、诺克斯学院、东华盛顿大学和华盛顿州立大学。该奖项旨在加强各级的研究和教育。这尤其影响到准分子材料的分子识别谱的研究。与医学相关的查尔酮正在被研究，以及设计小有机分子作为可能的药物伴侣。用衍射仪分析了α -二亚胺配体负载的铁催化剂的结构。该仪器还服务于近红外活性物质的开发项目。它被用于设计细胞色素450 2A6的小分子抑制剂的研究，这些抑制剂有可能用于戒烟。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Kraig Wheeler from Whitworth University and colleagues Jamie Manson from Eastern Washington University, Matthew E Cremeens from Gonzaga University and Travis Denton from Eastern Washington University have acquired a single crystal diffractometer. An X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule. This includes bond distances and angles. This provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. In one project, the research targets molecules that may serve as quantum magnets. In a green chemistry approach, catalysts containing iron are being synthesized that can replace other less expensive metals. Chalcones, materials with biological activity beneficial for anti-inflammation, are being studied. The diffractometer is used in a collaborative network to train and to provide undergraduate and graduate students with the principles of crystallography. The following institutions are the main members of the network: Whitworth University, Gonzaga University, Eastern Illinois University, Oakland University, Knox College, Eastern Washington University, and Washington State University. The award is aimed at enhancing research and education at all levels. It especially impacts studies of molecular recognition profiles of quasiracemic materials. Medicinal-relevant chalcones are being investigated as well as the design of small organic molecules as possible pharmaceutical chaperones. The diffractometer is used in structure analyses of iron catalysts supported by alpha-diimine ligands. This instrument also serves projects developing near-infrared active materials. It is used in research to design small molecule inhibitors of cytochrome 450 2A6 that have potential for use in stopping smokingThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.