Pathophysiology, treatment, and epidemiology of Lassa fever in Nigeria

尼日利亚拉沙热的病理生理学、治疗和流行病学

• 批准号: 234548442
• 负责人: Professor Dr. Stephan Günther
• 金额: --
• 依托单位: Institute of Lassa Fever Control
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/234548442?language=en
• 关键词: Pathophysiology; treatment; epidemiology; Lassa; fever

Lassa fever is a zoonotic disease caused by Lassa virus. The disease is endemic in West Africa. Hemorrhagic courses of Lassa fever are associated with high mortality. It is estimated that 100,000 to 500,000 infections occur each year as a result of transmission of Lassa virus from its rodent reservoir (Mastomys natalensis) to human. The overall objective of this proposal is the generation of knowledge to control Lassa fever in Africa at various levels: in the hospital, in the community, and the natural reservoir. The results shall be translatable into practice and reduce the burden of Lassa fever in the African environment. According to the overall objective, the approach is multidisciplinary involving virology, epidemiology, public health, genetics, and zoology. Experts in all these fields are included in the proposal either as applicants or as contributing partners. The disciplines are closely linked as all work is focussed on a common study site in Edo State, Nigeria. The specific objectives extend the objectives of the on-going project and are based on the preliminary results:1. Understanding the role of T cells in the pathophysiology of Lassa fever.2. Determination of incidence of Lassa fever in communities as basis for future vaccine trials.3. Identification of risk factors for transmission of Lassa virus from rodent to human.4. Understanding spatial, temporal and host-specific mutation patterns of the Lassa virus in Mastomys rodents within Nigeria5. Exploring the association between immunogenetics in Mastomys rodents and Lassa virus infection Status.

拉沙热是由拉萨病毒引起的人畜共患病。这种疾病是西非的地方病。拉沙热的出血过程与高死亡率有关。据估计，每年有100,000至500,000例感染是由于Lassa病毒从其啮齿动物储藏室传播给人类造成的。该提案的总体目标是产生知识，在医院、社区和天然水库等不同层面控制非洲的拉沙热。成果应可转化为实践，并减轻非洲环境中拉沙热的负担。根据总体目标，该方法是涉及病毒学、流行病学、公共卫生、遗传学和动物学的多学科。所有这些领域的专家都被列入提案，要么作为申请人，要么作为贡献伙伴。这些学科密切相关，因为所有工作都集中在尼日利亚江户州的一个共同研究地点。具体目标扩展了正在进行的项目的目标，并基于初步结果：1.了解T细胞在拉沙热的病理生理学中的作用。确定拉沙热在社区的发病率，作为未来疫苗试验的基础。确定拉萨病毒从啮齿动物向人传播的危险因素。了解尼日利亚Mastomys啮齿动物中Lassa病毒的空间、时间和宿主特异性突变模式5。探讨马斯泰鼠免疫遗传学与拉萨病毒感染状态的关系。