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MRI: Acquisition of an Inductively Coupled Plasma Mass Spectrometer (ICP-MS) System to Enable Elemental Analysis in Research, Training and Education

MRI：采购电感耦合等离子体质谱仪 (ICP-MS) 系统，以实现研究、培训和教育中的元素分析

基本信息

批准号：
1828234
负责人：
Mark Nanny
金额：
$ 39.68万
依托单位：
University of Oklahoma Norman Campus
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828234&HistoricalAwards=false
关键词：
MRI Acquisition Inductively Coupled Plasma

项目摘要

This award is to purchase an Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) with Laser Ablation and Liquid Chromatography capabilities. This ICP-MS system will measure the concentration of nearly all elements and their isotopes present in single mammalian cells, as well as complex liquid and solid samples. Research efforts will address core concerns of the south-central Plains region: healthcare technology, environment/population interactions, renewable energy, and water quality. This instrument will enable the collaborations among the University of Oklahoma (OU), Oklahoma State University (OSU) and the University of Tulsa (TU). Coordination with Oklahoma Tribal Nations will occur via research projects related to water quality issues pertinent to the Quapaw Tribal Environmental Office through the Tar Creek Superfund Site, and the Miami, Ottawa, Wyandotte, Shawnee, Eastern Shawnee, Modoc, Quapaw, Peoria and Seneca-Cayuga Nations through the Grand Lake Watershed Council. Oklahoma high school teachers will be engaged through the NSF-RET program "Rural Educators Engaged in Bioanalytical Engineering Research and Teaching" which targets rural students and teachers who are considered an underserved group in Oklahoma. The ICP-MS instrument to be funded is a PerkinElmer NexION2000 ICP-MS with various analytical capabilities. Single mammalian cells will be analyzed by being introduced individually into the ICP-MS using an Asperon Spray Chamber. The ICP-MS will be located at the OU Mass Spectrometry Core Facility, Stephenson Life Science Research Center, Norman, OK. The specific research topics to be addressed are: 1) Interactions of nanomaterials and drugs with individual cells, as well as assessment of cellular-metal metabolic behavior; 2) Reconstruction of population dynamics, mobility, and connectivity of organisms in prehistoric and current ecosystems; 3) Enhancement of renewable energy material performance as well as improvement of hydrocarbon systems; and 4) Characterization of organism-metal interactions within dynamic ecosystems to protect human health and improve water quality. aThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项旨在购买一台具有激光烧蚀和液相色谱功能的电感耦合等离子体质谱仪 (ICP-MS)。该 ICP-MS 系统将测量单个哺乳动物细胞以及复杂液体和固体样品中几乎所有元素及其同位素的浓度。研究工作将解决中南部平原地区的核心问题：医疗保健技术、环境/人口相互作用、可再生能源和水质。该工具将促进俄克拉荷马大学 (OU)、俄克拉荷马州立大学 (OSU) 和塔尔萨大学 (TU) 之间的合作。与俄克拉荷马州部落民族的协调将通过与夸帕部落环境办公室相关的水质问题相关的研究项目进行，通过焦油溪超级基金站点进行，迈阿密、渥太华、怀恩多特、肖尼、东肖尼、莫多克、夸帕、皮奥里亚和塞内卡-卡尤加民族通过大湖流域委员会进行协调。俄克拉荷马州高中教师将通过 NSF-RET 项目“从事生物分析工程研究和教学的农村教育者”参与其中，该项目针对的是俄克拉荷马州被认为服务不足的群体的农村学生和教师。获得资助的 ICP-MS 仪器是 PerkinElmer NexION2000 ICP-MS，具有各种分析功能。使用 Asperon 喷雾室将单个哺乳动物细胞单独引入 ICP-MS 进行分析。 ICP-MS 将位于俄克拉荷马州诺曼市斯蒂芬森生命科学研究中心的 OU 质谱核心设施。具体研究课题包括：1）纳米材料和药物与单个细胞的相互作用，以及细胞金属代谢行为的评估； 2）重建史前和当前生态系统中生物体的种群动态、流动性和连通性； 3）可再生能源材料性能的增强以及碳氢化合物系统的改进； 4) 表征动态生态系统内的生物体-金属相互作用，以保护人类健康并改善水质。 a该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。