权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effects of chronic psychosocial stress on the brain oxytocin (OXT) and neuropeptide S (NPS) systems, and potential stress-protective actions of chronic OXT and NPS administration

慢性心理社会压力对脑催产素 (OXT) 和神经肽 S (NPS) 系统的影响，以及慢性 OXT 和 NPS 给药的潜在压力保护作用

基本信息

批准号：
234728202
负责人：
Professorin Dr. Inga D. Neumann
金额：
--
依托单位：
Lehrstuhl für Neurobiologie und Tierphysiologie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/234728202?language=en
关键词：
Effects chronic psychosocial stress brain

项目摘要

The neuropeptide oxytocin (OXT) and neuropeptide S (NPS) have established anxiolytic (OXT, NPS) and antidepressive (OXT) effects, and modulate the acute neuroendocrine stress response. However, effects of chronic psychosocial stress on the adult brain OXT and NPS systems are largely unknown. Similarly, although chronic psychosocial stress results in increased anxiety levels, among others, effects of OXT or NPS administration on behavioural or neuroendocrine parameters in the context of chronic stress have never been assessed. Here, we aim to study the effects of an established chronic psychosocial stress paradigm, i.e. chronic subordinate colony housing (CSC) in mice, on the brain OXT and NPS systems with respect to neuronal expression of the neuropeptides and their receptors, as well as the responsiveness of the OXT system to a novel, acute stressor monitoring central (microdialysis in PVN, amygdala) and peripheral (jugular vein catheter) release patterns comparing single-housed control (SHC) and CSC mice. Moreover, we will test for potential anti-stress effects of chronic OXT and NPS administration via osmotic minipumps during and following CSC exposure, respectively, with respect to CSC-induced alterations in anxiety and selected physiological (body, adrenal and thymus weight, HPA axis (re)activity) and immunological (signs of colonic inflammation) parameters.

神经肽催产素（OXT）和神经肽S（NPK）具有抗焦虑（OXT，NPK）和抗抑郁（OXT）作用，并调节急性神经内分泌应激反应。然而，慢性心理社会应激对成人大脑OXT和OXT系统的影响在很大程度上是未知的。类似地，尽管慢性心理社会压力导致焦虑水平增加，但从未评估过在慢性压力背景下OXT或OXT给药对行为或神经内分泌参数的影响。在这里，我们的目的是研究一个既定的慢性心理社会应激范式，即小鼠慢性从属群体住房（CSC），对脑OXT和OXT系统的神经肽及其受体的神经元表达的影响，以及OXT系统对一种新的急性应激监测中枢的反应性。图2显示了比较单圈养对照（SHC）和CSC小鼠的外周（PVN、杏仁核中的微透析）和外周（颈静脉导管）释放模式。此外，我们将分别在CSC暴露期间和之后通过渗透微型泵长期给予OXT和OXT的潜在抗应激作用，关于CSC诱导的焦虑和选定的生理学（身体、肾上腺和胸腺重量、HPA轴（再）活性）和免疫学（结肠炎症体征）参数的变化。