Effects of Early Life Stress and Sleep Disturbance on Frontolimbic Development and Risk for Depression Across Adolescence
早期生活压力和睡眠障碍对前肢发育和青春期抑郁风险的影响
基本信息
- 批准号:10820857
- 负责人:
- 金额:$ 7.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-13 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:10 year old20 year oldAddressAdolescenceAdolescentAffectAffectiveAgeAmygdaloid structureAnteriorAreaAttenuatedBiologicalBrainBrain regionChildChildhoodChronicCognitiveCritical PathwaysDataData CollectionDevelopmentDiagnosisDorsalEarly identificationEcological ChangeEnvironmentExhibitsExperimental DesignsExposure toFamilyGrowthHealthHigh School StudentHippocampusHourIncidenceIndividualInstitutionInterventionLateralLinkLiteratureLongevityLongitudinal StudiesMajor Depressive DisorderMediatingMediationMental DepressionMental disordersMethodologyMethodsModelingNatureNeurobiologyOnset of illnessParticipantPathway interactionsPopulationPredictive FactorPrefrontal CortexPrevalencePreventionProcessPsychopathologyPubertyRecommendationRecurrenceRegulationReportingResearchResourcesRiskRisk FactorsSeveritiesSleepSleep DeprivationSleep DisordersSleep disturbancesStressStructureTechniquesTimeTrainingUnited StatesUniversitiesYouthaffective neuroscienceattenuationbiobehaviorcareerdata acquisitiondepressive symptomsdisabilityearly experienceearly life adversityearly life stressexperienceinsightinterestmultimodal datanegative affectneglectneurobiological mechanismneurodevelopmentnovelpsychosocialrisk predictionskillssleep qualitystress reactivitywhite matteryoung adult
项目摘要
Project Summary/Abstract
Major depressive disorder (MDD) is among the most prevalent, recurrent, and functionally debilitating of all
psychiatric disorders. The incidence of MDD rises sharply during adolescence, and individuals who have an
onset of MDD in adolescence tend to have a more chronic and severe course of depression than do those with
a later onset. Thus, there is an urgent need to develop effective approaches for early identification, prevention,
and intervention for MDD. Experiences of early life adversity (ELA), which affect over 40% of children, are a
strong predictor of MDD. Research suggests that one pathway by which ELA increases risk for MDD is through
alterations in the structural and functional development of frontolimbic regions implicated in stress reactivity
and regulation; however, the direction of these effects and how they unfold over time are not known. Moreover,
the biobehavioral mechanisms by which ELA influences neurodevelopment and risk for MDD are not well
understood. In this context, sleep disturbances is a significant risk factor for MDD across the lifespan and is an
underexplored pathway by which ELA might increase risk for MDD during adolescence. Sleep disturbances
tend to increase during adolescence due to a combination of normative biological and psychosocial changes;
indeed, over 70% of high-school students report getting insufficient sleep. Emerging research suggests that
adolescents with greater sleep disturbances have both attenuated white matter development in tracts that
connect frontolimbic regions and heightened frontolimbic reactivity to stress. The overlapping neurobiological
and health effects of ELA and sleep disturbances suggest that sleep disturbance is a critical pathway that links
ELA to frontolimbic alterations and increased risk for MDD. The proposed research addresses critical gaps in
the literature by examining the multivariate and longitudinal effects of ELA, sleep disturbances, and frontolimbic
connectivity during adolescence and how these factors predict risk for depression in young adulthood.
Leveraging data from a multimethod longitudinal study, the proposed project investigates sleep disturbances
as a pathway linking ELA with alterations in frontolimbic development and risk for MDD across adolescence
and young adulthood (9-20 years of age). The results of this project will not only increase our understanding of
the neurobiological mechanisms by which ELA relates to increased risk for MDD, but will also provide insight
into sleep disturbances as a potential target of intervention during adolescence to ameliorate the effects of
ELA. Moreover, the proposed training plan will enable the applicant to gain theoretical and methodological
expertise in studying the relations among ELA, sleep quality, frontolimbic development, and psychopathology
during adolescence, and to develop professional skills necessary to transition to an independent research
career. Stanford University, the institution at which the applicant will be training, has experts and resources
relevant to all domains of the proposal, making it an ideal training environment for the applicant.
项目总结/文摘
项目成果
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