Effects of Early Life Stress and Sleep Disturbance on Frontolimbic Development and Risk for Depression Across Adolescence

早期生活压力和睡眠障碍对前肢发育和青春期抑郁风险的影响

• 批准号: 10820857
• 负责人: Jessica Phuong Uy
• 金额: $ 7.43万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-13 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10820857
• 关键词: 10 year old; 20 year old; Address; Adolescence; Adolescent; Affect; Affective; Age; Amygdaloid structure; Anterior; Area; Attenuated; Biological; Brain; Brain region; Child; Childhood; Chronic; Cognitive; Critical Pathways; Data; Data Collection; Development; Diagnosis; Dorsal; Early identification; Ecological Change; Environment; Exhibits; Experimental Designs; Exposure to; Family; Growth; Health; High School Student; Hippocampus; Hour; Incidence; Individual; Institution; Intervention; Lateral; Link; Literature; Longevity; Longitudinal Studies; Major Depressive Disorder; Mediating; Mediation; Mental Depression; Mental disorders; Methodology; Methods; Modeling; Nature; Neurobiology; Onset of illness; Participant; Pathway interactions; Population; Predictive Factor; Prefrontal Cortex; Prevalence; Prevention; Process; Psychopathology; Puberty; Recommendation; Recurrence; Regulation; Reporting; Research; Resources; Risk; Risk Factors; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Stress; Structure; Techniques; Time; Training; United States; Universities; Youth; affective neuroscience; attenuation; biobehavior; career; data acquisition; depressive symptoms; disability; early experience; early life adversity; early life stress; experience; insight; interest; multimodal data; negative affect; neglect; neurobiological mechanism; neurodevelopment; novel; psychosocial; risk prediction; skills; sleep quality; stress reactivity; white matter; young adult

Project Summary/Abstract Major depressive disorder (MDD) is among the most prevalent, recurrent, and functionally debilitating of all psychiatric disorders. The incidence of MDD rises sharply during adolescence, and individuals who have an onset of MDD in adolescence tend to have a more chronic and severe course of depression than do those with a later onset. Thus, there is an urgent need to develop effective approaches for early identification, prevention, and intervention for MDD. Experiences of early life adversity (ELA), which affect over 40% of children, are a strong predictor of MDD. Research suggests that one pathway by which ELA increases risk for MDD is through alterations in the structural and functional development of frontolimbic regions implicated in stress reactivity and regulation; however, the direction of these effects and how they unfold over time are not known. Moreover, the biobehavioral mechanisms by which ELA influences neurodevelopment and risk for MDD are not well understood. In this context, sleep disturbances is a significant risk factor for MDD across the lifespan and is an underexplored pathway by which ELA might increase risk for MDD during adolescence. Sleep disturbances tend to increase during adolescence due to a combination of normative biological and psychosocial changes; indeed, over 70% of high-school students report getting insufficient sleep. Emerging research suggests that adolescents with greater sleep disturbances have both attenuated white matter development in tracts that connect frontolimbic regions and heightened frontolimbic reactivity to stress. The overlapping neurobiological and health effects of ELA and sleep disturbances suggest that sleep disturbance is a critical pathway that links ELA to frontolimbic alterations and increased risk for MDD. The proposed research addresses critical gaps in the literature by examining the multivariate and longitudinal effects of ELA, sleep disturbances, and frontolimbic connectivity during adolescence and how these factors predict risk for depression in young adulthood. Leveraging data from a multimethod longitudinal study, the proposed project investigates sleep disturbances as a pathway linking ELA with alterations in frontolimbic development and risk for MDD across adolescence and young adulthood (9-20 years of age). The results of this project will not only increase our understanding of the neurobiological mechanisms by which ELA relates to increased risk for MDD, but will also provide insight into sleep disturbances as a potential target of intervention during adolescence to ameliorate the effects of ELA. Moreover, the proposed training plan will enable the applicant to gain theoretical and methodological expertise in studying the relations among ELA, sleep quality, frontolimbic development, and psychopathology during adolescence, and to develop professional skills necessary to transition to an independent research career. Stanford University, the institution at which the applicant will be training, has experts and resources relevant to all domains of the proposal, making it an ideal training environment for the applicant.

项目总结/文摘