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Cellular and synaptic analysis of rodent social facial touch

啮齿动物社交面部触摸的细胞和突触分析

基本信息

批准号：
235272554
负责人：
Professor Dr. Michael Brecht
金额：
--
依托单位：
Institut für Biologie
依托单位国家：
德国
项目类别：
Research Units
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/235272554?language=en
关键词：
Cellular synaptic analysis rodent social

项目摘要

The exquisite topographic representation of the whiskers in the barrel cortex and the fact that whiskers can be easily accessed for manipulation or stimulation has greatly contributed to the success of this model system. The quantitatively controlled tactile stimulation of single whiskers in anesthetized animals provided a high-resolution picture of physiology of the whisker system that is unmatched in any other mammalian sensory system. Nevertheless we are still ignorant about how the whisker-to-barrel system processes complex biologically meaningful stimuli. This theme – the processing of complex biologically meaningful stimuli – will be pursued in this project. Specifically we will investigate the neural representation of social facial touch in the rodent barrel cortex. This project consists of four work packages and will build on our previous work on social facial touch and the development for recording techniques in awake, behaving animals. In work package 1 we will analyze neural responses to passive social touch (being touched) in anesthetized animals. In work package 2 we will establish and validate a head-fixed preparation for analyzing intracellular responses in barrel cortex during social touch. In work package 3 will apply the techniques established in WP2 to characterize the neural representation of social facial touch in the rat barrel cortex. In work package 4 we will prepare to extend the work in head-fixed animals to freely interacting / moving animals. Our project will elucidate the cellular basis of social touch and will for the first time provide insight into the processing of complex stimuli in the barrel cortex.

桶状皮层中晶须的精致地形表征以及晶须易于操作或刺激的事实极大地促进了该模型系统的成功。对麻醉动物的单须进行定量控制的触觉刺激，提供了任何其他哺乳动物感觉系统无法比拟的须系统生理学的高分辨率图像。然而，我们仍然不知道从须到桶的系统是如何处理复杂的有生物学意义的刺激的。这个主题-处理复杂的生物学上有意义的刺激-将在这个项目中进行。具体来说，我们将研究社交面部触摸在啮齿动物桶状皮层中的神经表征。这个项目由四个工作包组成，将建立在我们之前关于社会面部触摸的工作和在清醒的、有行为的动物中记录技术的发展。在工作包1中，我们将分析麻醉动物对被动社交接触（被触摸）的神经反应。在工作包2中，我们将建立并验证头部固定准备，用于分析社交接触时桶状皮层的细胞内反应。在工作包3将应用WP2中建立的技术来表征大鼠桶状皮层中社交面部触摸的神经表征。在工作包4中，我们将准备将头部固定动物的工作扩展到自由互动/移动的动物。我们的项目将阐明社会接触的细胞基础，并将首次提供对桶状皮层中复杂刺激处理的见解。