Early and late Endothelial Outgrowth Cells in acute ischemic kidney injury and Endothelial-Mesenchymal Transition

急性缺血性肾损伤和内皮间质转化中的早期和晚期内皮生长细胞

• 批准号: 236035823
• 负责人: Professor Dr. Daniel Patschan
• 金额: --
• 依托单位: Molekulare und optische Phasenzellen-Darstellung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/236035823?language=en
• 关键词: Early; late; Endothelial; Outgrowth; Cells

Acute ischemic renal failure (ARF) significantly increases morbidity and mortality of hospitalized patients. The long-term prognosis of ARF critically depends on postischemic interstitial renal fibrosis. Newer data indicate that renal fibrosis partly results from mesenchymal transition of peritubular microvascular endothelial cells. Early and late Endothelial Outgrowth Cells, which both belong to the Endothelial Progenitor Cell population, have been shown to act vasoprotective under physiological and pathological conditions. Early EOCs protect mice from acute renal failure. Aim of the study is to analyze whether these cells can be employed for inhibiting postischemic renal fibrosis due to Endothelial-Mesenchymal transition.

急性缺血性肾衰竭（ARF）显着增加住院患者的发病率和死亡率。 ARF的长期预后关键取决于缺血后肾间质纤维化。新的数据表明，肾纤维化部分是由管周微血管内皮细胞的间质转化引起的。早期和晚期内皮生长细胞均属于内皮祖细胞群，已被证明在生理和病理条件下具有血管保护作用。早期 EOC 可以保护小鼠免受急性肾衰竭。该研究的目的是分析这些细胞是否可以用于抑制内皮-间质转化引起的缺血后肾纤维化。