Living Interfaces: Exploring Synthetic Biology and Evolution for the Development of Next-Generation Biomaterials

生命界面：探索合成生物学和进化以开发下一代生物材料

• 批准号: 1849678
• 负责人: MG Finn
• 金额: $ 5万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1849678&HistoricalAwards=false
• 关键词: Living; Interfaces; Exploring; Synthetic; Biology

This proposal seeks support for the participation of leading experts from academia and funding agencies to explore the role of biomaterials for synthetic biology and for synthetic biology and evolution for the development of next-generation biomaterials. The theme of the workshop is "Living Interfaces" - understanding and controlling interfacial emergent bio-like order and function in far-from-equilibrium synthetic biomaterials systems. The aim is to use the results that emerge from the talks and discussion during the Square-Table workshop to write a report that captures the excitement and promise of this rapidly growing field of research for the various communities and agencies to use as a road-map. The proposal is to hold the workshop in Alexandria, VA in the early part of the week of 3 December 2018. This Square-Table will engage representatives from the biomaterials, synthetic biology, and molecular evolution communities, along with funding agencies, regulators and industry. The intent is to accelerate the discovery and deployment of disruptive technologies in materials development, with important contributions expected from each of these perspectives. The focus on "Living Interfaces" frames an exciting first challenge, the successful prosecution of which will open many other avenues of collaboration and research.The agenda is designed to identify gaps and challenges to a new paradigm for biomaterials discovery, taking advantage of synthetic biology and evolutionary approaches in ways inspired, but not on strained, by nature. The advances in biomaterials recently can bring new understanding of fundamental processes and functions covering a wide range of applications. The convergence of NSF interests in Rules of Life as part of the ten Big Ideas and so it is time to devote significant attention to understanding how organisms discover and make new materials, to expand the range of what constitutes a functional biomaterial, to use engineered or artificial "living" systems to create novel and sustainable materials for significant functions, and to extract fundamental lessons that relate structure to function. The aim is to define the outlines of an exciting new field of evolvable materialsThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该提案寻求学术界和资助机构的主要专家的参与，以探讨生物材料在合成生物学以及合成生物学和进化在开发下一代生物材料方面的作用。研讨会的主题是“生命界面”--理解和控制界面在远离平衡的合成生物材料系统中出现的类生物秩序和功能。其目的是利用方桌研讨会期间会谈和讨论的结果撰写一份报告，捕捉这一快速增长的研究领域的兴奋和希望，供不同的社区和机构用作路线图。提议于2018年12月3日当周早些时候在弗吉尼亚州亚历山大市举办研讨会。这个方桌将吸引来自生物材料、合成生物学和分子进化社区的代表，以及资助机构、监管机构和行业。其目的是加快材料开发中颠覆性技术的发现和部署，预计每个角度都将做出重要贡献。对“生活界面”的关注构成了令人兴奋的第一个挑战，成功地开展这项挑战将打开许多其他合作和研究的途径。议程旨在确定生物材料发现新范式的差距和挑战，以自然启发而不是紧张的方式利用合成生物学和进化方法。最近生物材料的进展可以带来对基本过程和功能的新理解，涵盖了广泛的应用。NSF在生命规则方面的利益汇聚是十大想法的一部分，因此，现在是时候非常关注了解生物体如何发现和制造新材料，扩大什么是功能生物材料的范围，使用工程或人工“活”系统为重要功能创造新颖和可持续的材料，并提取将结构与功能联系起来的基本经验教训。该奖项反映了NSF的法定使命，通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。