ST2: Programmable Interfaces- Exploring the Intersection of Synthetic Biology, Biomaterials, and Soft Matter

ST2：可编程接口 - 探索合成生物学、生物材料和软物质的交叉点

基本信息

批准号：
1939310
负责人：
Allen Po-Chih Liu
金额：
$ 10万
依托单位：
Regents of the University of Michigan - Ann Arbor
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1939310&HistoricalAwards=false
关键词：
ST2 Programmable Interfaces Exploring Intersection

项目摘要

The award supports a Square-Table workshop, the second of its kind, to explore the intersection of synthetic biology, biomaterials, and soft matter. Following the success of the first workshop on Living Interfaces held in Alexandria, VA in December 2018, the theme of this workshop, Square-Table 2 (ST2), is on Programmable Interfaces. Despite significant growth over the years in the areas of synthetic biology and biomaterials / soft matter as independent subjects, there exists relatively untapped potential to harness synthetic biology for design and synthesis of novel biomaterials. Synthetic biology promises to design new functionality in natural cells (both microbial or mammalian cells) as well as constructing de novo systems from the bottom-up. Biomaterials, whether chemically synthesized, engineered, or naturally secreted by cells may have a range of biotechnology and biomedical applications. The myriad of biomaterials in the natural world, arisen from evolution and natural selection, provides a rich testbed for understanding biomaterials / soft matter design. Combined with the ability of synthetic biology approaches to program desirable biological outputs, the timing to explore the programmable interface of synthetic biology and biomaterials is fitting. Square-Table 1 (ST1) identified a need for computational capabilities to analyze materials composition-property relationship in this space and ST2 will attempt to enrich the continuing discussion at this interface by also bringing in computational modelers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项支持一个方形的研讨会，即第二个研讨会，以探讨合成生物学，生物材料和软质的交集。在2018年12月在弗吉尼亚州亚历山大举行的第一个关于生活界面的研讨会成功之后，该研讨会的主题是Square-Table 2（ST2），是在可编程界面上。尽管多年来在合成生物学和生物材料 /软物质作为独立受试者的领域中有显着的增长，但仍存在相对未开发的潜力来利用合成生物学来设计和合成新型生物材料。合成生物学有望在天然细胞（微生物或哺乳动物细胞）中设计新功能，并从自下而上构建从头系统。生物材料，无论是化学合成，设计还是由细胞天然分泌的生物材料都可能具有一系列的生物技术和生物医学应用。自然世界中的无数生物材料是由进化和自然选择引起的，为了解生物材料 /软物质设计提供了丰富的测试。结合合成生物学方法编程理想的生物产量的能力，探索合成生物学和生物材料的可编程界面的时机很合适。 Square-table 1（ST1）确定了计算能力的需求，以分析该领域的材料组成 - 特制关系，而ST2将尝试通过还通过该基金会的知识优点和广泛的crietia criperia criperia criperia criperia criperia criptiation评估来实现计算机建模的持续讨论。