Collaborative Research: Phylogenomics and Cytonuclear Coevolution of Papilionoid Legumes

合作研究:蝶形科豆科植物的系统基因组学和细胞核协同进化

基本信息

  • 批准号:
    1853010
  • 负责人:
  • 金额:
    $ 29.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

Each plant species has three genomes housed in the nucleus, mitochondrion, and chloroplast whose activities are tightly coordinated. Proteins encoded by the chloroplast and mitochondrial genomes must interact with nuclear-encoded proteins in order for essential processes, such as photosynthesis, to occur. Consequently, mismatches among these interacting proteins may prevent genetically divergent individuals from producing viable hybrid offspring. This genomic coordination, or coevolution, is hypothesized to drive plant species diversification but is largely uncharacterized among closely related species. This project will examine this phenomenon using the papilionoid group of legumes, which include economically important crops, such as soybeans, alfalfa, and peanuts, and nitrogen-fixing species that have significant ecological impacts. Researchers will resolve the evolutionary relationships among the major lineages of this group using DNA sequence data from all three genomes and will study the role of genomic coevolution during this lineage's expansion over time. The project will provide training at the undergraduate, graduate and post-graduate levels in genomics, plant biology, and evolutionary biology and will recruit students from underrepresented groups. Outreach activities include the development of teaching modules and job-shadowing experiences for K-12 students. This project will provide a robust framework to address outstanding questions regarding legume systematics and genome coevolution. Papilionoid legumes have accelerated rates of nucleotide substitution in organellar genomes, highly rearranged plastomes that exhibit biparental inheritance and plastome-genome incompatibility, which make them ideal models for characterizing genomic coevolution during lineage diversification. Phylogenetic relationships of the papilionoid legumes will be inferred using plastid and mitochondrial genome data as well as nuclear transcriptomes for 56 species representing each of the 22 major clades, including early diverging and poorly known lineages. Cytonuclear coevolution analyses will compare nucleotide substitution rates between organelle and nuclear genes whose products interact. Researchers will then determine whether coordinated changes among the gene products are occurring on the same branch of the papilionoid phylogeny, which would indicate coevolutionary coordination. The final aim of the research will further test the correlation between high rates of sequence evolution in nuclear-encoded DNA repair, recombination and replication genes and mitochondrial and plastid genome complexity. Results of the research will be shared widely in publications, public databases and other publicly-accessible internet resources. Outcomes of the research will provide new insights into possible genomic mechanisms that govern species boundaries and will strengthen research infrastructure to support advances in phylogenetic biology and agricultural improvement.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
每个植物物种都有三个基因组,分别位于细胞核、叶绿体和叶绿体中,它们的活动紧密协调。由叶绿体和线粒体基因组编码的蛋白质必须与核编码的蛋白质相互作用,以进行必要的过程,如光合作用。因此,这些相互作用的蛋白质之间的错配可能会阻止遗传上不同的个体产生可行的杂交后代。这种基因组协调或共同进化被假设为驱动植物物种多样化,但在密切相关的物种中基本上没有特征。本项目将利用豆科蝶形花科植物研究这一现象,其中包括大豆、苜蓿和花生等经济上重要的作物,以及具有重大生态影响的固氮物种。研究人员将使用来自所有三个基因组的DNA序列数据来解决这一群体的主要谱系之间的进化关系,并将研究基因组协同进化在这一谱系随着时间的推移而扩展过程中的作用。该项目将提供基因组学、植物生物学和进化生物学方面的本科生、研究生和研究生培训,并将从代表性不足的群体中招收学生。外联活动包括为K-12学生开发教学模块和工作跟踪体验。该项目将提供一个强有力的框架,以解决有关豆类系统学和基因组共同进化的悬而未决的问题。蝶形豆科植物细胞器基因组中的核苷酸取代速率加快,高度重排的质体表现出双亲遗传和质体基因组不相容性,这使它们成为表征谱系多样化过程中基因组协同进化的理想模型。系统发育关系的papilipiliplegumes将推断使用质体和线粒体基因组数据,以及核转录组的56种代表的22个主要分支,包括早期分歧和鲜为人知的血统。细胞核协同进化分析将比较细胞器和核基因之间的核苷酸取代率,其产物相互作用。然后,研究人员将确定这些基因产物之间的协调变化是否发生在蝶形类进化的同一分支上,这将表明共同进化的协调。该研究的最终目的将进一步测试核编码DNA修复,重组和复制基因的高序列进化率与线粒体和质体基因组复杂性之间的相关性。研究结果将在出版物、公共数据库和其他公众可访问的互联网资源中广泛分享。该研究成果将为管理物种边界的可能基因组机制提供新的见解,并将加强研究基础设施,以支持系统发育生物学和农业改良的进步。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(1)
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Martin Wojciechowski其他文献

Martin Wojciechowski的其他文献

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{{ truncateString('Martin Wojciechowski', 18)}}的其他基金

EAGER: Collaborative Research: Plastid genome evolution in Cactaceae, a New World succulent radiation
EAGER:合作研究:仙人掌科质体基因组进化,一种新世界肉质辐射
  • 批准号:
    1735604
  • 财政年份:
    2017
  • 资助金额:
    $ 29.76万
  • 项目类别:
    Standard Grant
US-Argentina Dissertation: An Investigation of Novel Morphologies and Ecology Involved, Rapid Diversification and Trans-Oceanic Dispersal of the Legume Sesbania (Leguminosae)
美国-阿根廷论文:对豆科田菁(Leguminosae)的新形态和生态、快速多样化和跨洋传播的调查
  • 批准号:
    0812994
  • 财政年份:
    2008
  • 资助金额:
    $ 29.76万
  • 项目类别:
    Standard Grant
Molecular systematics of the temperate IR-lacking Clade of Papilionoid Legumes (Leguminosae) and the Evolution of Nod Factor Receptor Genes
温带 IR 缺乏的蝶形豆科 (Leguminosae) 分支的分子系统学和 Nod 因子受体基因的进化
  • 批准号:
    0542958
  • 财政年份:
    2006
  • 资助金额:
    $ 29.76万
  • 项目类别:
    Standard Grant

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