Conjugated Systems Containing Antiaromatic Cyclobutadienoids: Synthesis and Study of the Multifaceted Effects of Local Antiaromaticity

含有抗芳香环丁二烯类化合物的共轭体系：局部抗芳香性多方面效应的合成和研究

• 批准号: 1855922
• 负责人: Yan Xia
• 金额: $ 44.1万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1855922&HistoricalAwards=false
• 关键词: Conjugated; Systems; Containing; Antiaromatic; Cyclobutadienoids

In this project, funded by the Chemical Structure, Dynamic & Mechanism B Program of the Chemistry Division, Professor Yan Xia of the Department of Chemistry at Stanford University is developing a diverse family of carbon-rich conjugated molecules containing unusual antiaromatic cyclobutadienoids (CBDs) to control and understand the complex effects of antiaromaticity for future organic electronic applications. Conjugated molecules are critical materials for various optical and electronic applications. While they predominantly consist of aromatic frameworks, introducing CBD antiaromatic motifs has long been sought as a novel strategy to achieve favorable molecular properties, but conjugated CBDs are previously challenging to access. The proposed research will generate several unprecedented series of CBD-containing conjugated molecules, new fundamental insights into the control and influence of antiaromaticity, and new types of conjugated materials. This project integrates organic synthesis, design and advanced physical measurement of conjugated materials, and computation, providing a highly interdisciplinary and collaborative environment for training and outreach at graduate, undergraduate, and high school levels for students at Stanford and from the Bay Area.Carbon-rich conjugated molecules are of significant fundamental and technical interest for their optoelectronic properties and applications. Conjugated systems containing 4 pi-electron antiaromatic cyclobutadienoids (CBDs) have been challenging to synthesize, thus limiting the understanding of the multifaceted effects of CBD in extended pi-systems. This project will leverage the methodology that the Professor Xia's group has recently developed to synthesize several series of CBD-containing polycyclic conjugated hydrocarbons with different topologies, sizes of conjugation, conformations, and electronic characteristics. Experimental and computational investigations of these series of molecules will be carried out to answer the following questions: 1) How to modulate the degree of CBD antiaromaticity? 2) How does antiaromaticity affect frontier molecular orbitals, pi-bonding structures and conformations, optoelectronic properties, and carrier mobility? 3) How to tune these molecular properties of aromatic frameworks by designed fusion of CBD motifs?This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在该项目中，由化学系化学结构、动力学与机理B项目资助，斯坦福大学化学系夏岩教授正在开发多种富含碳的共轭分子，其中含有不寻常的抗芳香环丁二烯类化合物（CBD），以控制和理解反芳香性对未来有机电子应用的复杂影响。 共轭分子是各种光学和电子应用的关键材料。虽然它们主要由芳香框架组成，但引入 CBD 反芳香基序长期以来一直被视为实现有利分子特性的新策略，但共轭 CBD 以前很难获得。拟议的研究将产生几个前所未有的系列含有 CBD 的共轭分子，对反芳香性的控制和影响的新的基本见解，以及新型共轭材料。该项目整合了共轭材料的有机合成、设计和先进物理测量以及计算，为斯坦福大学和湾区的学生提供了一个高度跨学科和协作的环境，为研究生、本科生和高中水平的学生提供培训和推广。富碳共轭分子对其光电特性和应用具有重要的基础和技术意义。含有 4 个 pi 电子反芳香环丁二烯类化合物 (CBD) 的共轭系统的合成一直具有挑战性，因此限制了对 CBD 在扩展 pi 系统中多方面作用的理解。该项目将利用夏教授团队最近开发的方法来合成多个系列的含有CBD的多环共轭碳氢化合物，这些碳氢化合物具有不同的拓扑结构、共轭尺寸、构象和电子特性。对这一系列分子进行实验和计算研究，以回答以下问题：1）如何调节CBD反芳香性的程度？ 2）反芳香性如何影响前沿分子轨道、π键结构和构象、光电性质和载流子迁移率？ 3) 如何通过 CBD 基序的设计融合来调整芳香框架的这些分子特性？该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Synthesis of Contorted Polycyclic Conjugated Hydrocarbons via Regioselective Activation of Cyclobutadienoids

通过环丁二烯类化合物的区域选择性活化合成扭曲多环共轭烃

• DOI: 10.1021/jacs.2c02457
• 发表时间: 2022
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Yin, Xianglin;Zheng, Ke;Jin, Zexin;Horst, Matias;Xia, Yan
• 通讯作者: Xia, Yan