Enantioselective Catalysis Enabled by Imidazole-Based Biaryl Ligands

基于咪唑的联芳基配体实现对映选择性催化

• 批准号: 1900299
• 负责人: Aaron Aponick
• 金额: $ 45万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1900299&HistoricalAwards=false
• 关键词: Enantioselective; Catalysis; Enabled; Imidazole; Based

With this award, the Chemical Synthesis Program of the Division of Chemistry is supporting the research of Professor Aaron Aponick of the Department of Chemistry at the University of Florida. The project focuses on the design of new kinds metal-containing complexes used in the synthesis of organic compounds used in agriculture, clean energy technologies and pharmaceuticals. The chemical industry relies on such reactions as means of producing new compounds and materials more easily than classical reaction chemistry (with less energy, time or required separations). The team led by Professor Aponick is developing catalysts that show promise for the applications in advanced manufacturing. This project also provides hands-on training for students. Public outreach is achieved by public lectures at the University of Florida. Public outreach also includes Chemistry Day at the Mall, Molecular Mania. This event is popular with children and fosters interactions with the public in general. Many visitors with diverse socioeconomic backgroundsparticipate.The Chemical Synthesis Program of the Division of Chemistry is supporting the research of Professor Aaron Aponick of the Department of Chemistry at the University of Florida who is developing a new class of ligands for homogeneous catalysis. His "P-N" ligands incorporates imidazole substituents in an atropisomeric chiral biaryl backbone. Many P,N-ligands are known, but Professor Aponick's imidazole-based systems exhibit distinctive and often superior catalytic behavior. A major aim of the research is to elucidate the principles underpinning the reactivity and selectivity imparted by this modular ligand platform. Mechanistic studies are being employed to provide a fundamental understanding of the organometallic chemistry. The Aponick group is utilizing kinetic and crystallographic studies to interrogate how the coordination chemistry of these so-called Stack-ligands influences the catalytic activity. Further studies utilize the more basic and geometrically constrained imidazole moiety to enable new reactions that rely on what appears to be a bifunctional and hemilabile coordination motif. With this strategy, new enantioselective copper- and palladium-catalyzed reactions are being developed. This research program is providing hands-on training for students. Their professional development is emphasized in all aspects of the work.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

通过这一奖项，化学系的化学合成计划正在支持佛罗里达大学化学系的亚伦·阿波尼克教授的研究。该项目的重点是设计新型含金属络合物，用于合成用于农业、清洁能源技术和制药的有机化合物。化学工业依赖这样的反应作为产生新化合物和材料的手段，比传统的反应化学更容易(以更少的能量、时间或需要分离)。由阿波尼克教授领导的团队正在开发催化剂，这些催化剂在先进制造中的应用前景广阔。该项目还为学生提供实践培训。公众宣传是通过在佛罗里达大学的公开讲座实现的。公众宣传还包括分子狂热购物中心的化学日。这项活动很受儿童欢迎，并促进了与公众的互动。许多具有不同社会经济背景的参观者参加。化学系的化学合成计划正在支持佛罗里达大学化学系的亚伦·阿波尼克教授的研究，他正在开发一种用于均相催化的新型配体。他的“P-N”配体在一个异构体手性联芳基主链上引入了咪唑取代基。许多P，N-配体是已知的，但阿波尼克教授的基于咪唑的体系表现出独特的，往往是优越的催化行为。这项研究的一个主要目的是阐明支持这种模块化配体平台所赋予的反应性和选择性的原理。机理研究被用来提供对有机金属化学的基本理解。Aponick小组正在利用动力学和结晶学研究来询问这些所谓的Stack-配体的配位化学如何影响催化活性。进一步的研究利用更基本和几何受限的咪唑部分来实现新的反应，这些反应似乎依赖于一个双官能团和半分子配位基序。通过这一策略，正在开发新的铜和钯催化的对映选择性反应。这个研究项目正在为学生提供实践培训。他们的专业发展在工作的各个方面都得到了强调。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。