Enantioselective Catalysis Enabled by Imidazole-Based Biaryl Ligands

通过这个奖项，化学系的化学合成项目支持了佛罗里达大学化学系的Aaron Aponick教授的研究。该项目侧重于设计新型含金属配合物，用于合成农业、清洁能源技术和药品中使用的有机化合物。化学工业依靠这种反应来生产新化合物和新材料，比传统的反应化学更容易（更少的能量、时间或所需的分离）。Aponick教授领导的团队正在开发催化剂，有望应用于先进制造业。该项目还为学生提供实践培训。佛罗里达大学通过公开讲座实现了公众宣传。公众宣传活动还包括化学日在商场，分子狂热。这个活动很受孩子们的欢迎，并促进了与公众的互动。许多具有不同社会经济背景的游客参与其中。化学系的化学合成项目支持佛罗里达大学化学系的Aaron Aponick教授的研究，他正在开发一类用于均相催化的新型配体。他的“P-N”配体将咪唑取代基结合在一个atrosom异构手性联芳基骨架中。许多P， n配体是已知的，但Aponick教授的咪唑基系统表现出独特的，往往是优越的催化行为。该研究的主要目的是阐明该模块化配体平台赋予的反应性和选择性的基础原理。机械研究被用来提供对有机金属化学的基本理解。Aponick小组正在利用动力学和晶体学研究来探究这些所谓的堆叠配体的配位化学如何影响催化活性。进一步的研究利用更基本的和几何约束的咪唑片段来实现依赖于似乎是双功能和半稳定配位基序的新反应。利用这一策略，新的对映选择性铜和钯催化反应正在发展。这个研究项目为学生提供实践训练。在工作的各个方面都强调他们的专业发展。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With this award, the Chemical Synthesis Program of the Division of Chemistry is supporting the research of Professor Aaron Aponick of the Department of Chemistry at the University of Florida. The project focuses on the design of new kinds metal-containing complexes used in the synthesis of organic compounds used in agriculture, clean energy technologies and pharmaceuticals. The chemical industry relies on such reactions as means of producing new compounds and materials more easily than classical reaction chemistry (with less energy, time or required separations). The team led by Professor Aponick is developing catalysts that show promise for the applications in advanced manufacturing. This project also provides hands-on training for students. Public outreach is achieved by public lectures at the University of Florida. Public outreach also includes Chemistry Day at the Mall, Molecular Mania. This event is popular with children and fosters interactions with the public in general. Many visitors with diverse socioeconomic backgroundsparticipate.The Chemical Synthesis Program of the Division of Chemistry is supporting the research of Professor Aaron Aponick of the Department of Chemistry at the University of Florida who is developing a new class of ligands for homogeneous catalysis. His "P-N" ligands incorporates imidazole substituents in an atropisomeric chiral biaryl backbone. Many P,N-ligands are known, but Professor Aponick's imidazole-based systems exhibit distinctive and often superior catalytic behavior. A major aim of the research is to elucidate the principles underpinning the reactivity and selectivity imparted by this modular ligand platform. Mechanistic studies are being employed to provide a fundamental understanding of the organometallic chemistry. The Aponick group is utilizing kinetic and crystallographic studies to interrogate how the coordination chemistry of these so-called Stack-ligands influences the catalytic activity. Further studies utilize the more basic and geometrically constrained imidazole moiety to enable new reactions that rely on what appears to be a bifunctional and hemilabile coordination motif. With this strategy, new enantioselective copper- and palladium-catalyzed reactions are being developed. This research program is providing hands-on training for students. Their professional development is emphasized in all aspects of the work.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.