SusChEM: Direct functionalization of aldehydes enabled by aminocatalysis
SusChEM:通过氨基催化实现醛的直接官能化
基本信息
- 批准号:1903983
- 负责人:
- 金额:$ 8.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-02-15 至 2019-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Chemical Synthesis Program of the NSF Chemistry Division supports the research of Professor Wei Wang in the Department of Chemistry & Chemical Biology at the University of New Mexico. Professor Wang and his students develop cost-effective and environmentally friendly technologies for organic synthesis based on the concept of aminocatalysis. The goal of this research is to develop and exploit new organocatalytic activation modes for organic transformations. New chemistries are transformed into powerful synthetic methods for the facile and atom-economic synthesis of versatile building blocks starting from simple and readily available chemicals. The syntheses are also conducted under mild reaction conditions. These "one-pot" cascade methods, used to make complex molecular architectures, address critical challenges in modern organic synthesis. The methods include the improvement of synthetic efficiency, the use of sustainable and inexpensive chemicals, the avoidance of toxic agents, and the reduction of waste and hazardous byproducts. As a consequence of operational simplicity, mild reaction conditions and environmental friendliness, this research is well suited for the education of scientists at all levels. Professor Wang's group is well positioned to provide education and training for students from groups that are underrepresented in science.This project continues efforts aimed at expanding the scope of aminocatalysis beyond the well-established activation modes of enamine and iminium catalysis. Professor Wang and his team challenge mechanistic dogma by showing that amine moieties in adducts which result from nucleophilic additions to iminum ions can serve as leaving groups in ensuing nucleophilic substitution reactions. In situ release of the intermediate amine addition products creates a new scenario for aminocatalytic direct functionalization of aldehydes. This research demonstrates that through careful manipulation of the electronic and steric properties of catalysts and reactants, judicious design and selection of amine catalysts, and optimization of reaction conditions, new and powerful catalytic cascade reactions are developed. Given the ready accessibility, reactivity and broad structural diversity of aldehydes, a wide array of new synthetic building blocks and biologically-important complex molecular architectures are constructed in efficient one-pot reactions. The educational plan continues a tradition to recruit undergraduate students especially from underrepresented minority groups over the summer to conduct research in Dr. Wang's laboratory. Dr. Wang also integrates the research results and experiments from in his academic laboratory into his undergraduate students' experiences.
NSF化学部的化学合成项目支持新墨西哥州大学化学生物学系王伟教授的研究。 王教授和他的学生基于氨基催化的概念开发了成本效益和环境友好的有机合成技术。 本研究的目的是开发和利用新的有机催化活化模式的有机转化。 新的化学转化为强大的合成方法,从简单和容易获得的化学物质开始,简单和原子经济地合成多功能的结构单元。 合成也在温和的反应条件下进行。 这些用于制造复杂分子结构的“一锅法”级联方法解决了现代有机合成中的关键挑战。这些方法包括提高合成效率,使用可持续和廉价的化学品,避免有毒试剂,减少废物和危险副产品。 由于操作简单,反应条件温和和环境友好,这项研究非常适合各级科学家的教育。 王教授的研究小组有能力为那些在科学领域代表性不足的学生提供教育和培训。该项目继续努力,旨在将氨基催化的范围扩展到烯胺和亚胺催化的成熟活化模式之外。 王教授和他的团队挑战机械论教条,他们证明了亚胺离子亲核加成产生的加合物中的胺部分可以在随后的亲核取代反应中作为离去基团。中间体胺加成产物的原位释放为醛的氨基催化直接官能化创造了新的场景。 本研究表明,通过仔细操纵催化剂和反应物的电子和空间性质,明智的设计和选择胺催化剂,以及优化反应条件,开发新的和强大的催化级联反应。鉴于醛的容易获得性、反应性和广泛的结构多样性,在有效的一锅反应中构建了大量新的合成结构单元和生物学上重要的复杂分子结构。 教育计划延续了一个传统,即在夏季招收本科生,特别是来自代表性不足的少数民族的学生,在王博士的实验室进行研究。 王博士还将他的学术实验室的研究成果和实验融入他的本科生的经验。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Wei Wang其他文献
A High-Performance Isolated High-Frequency Converter With Optimal Switch Impedance
具有最佳开关阻抗的高性能隔离式高频转换器
- DOI:
10.1109/tie.2018.2868031 - 发表时间:
2019-07 - 期刊:
- 影响因子:7.7
- 作者:
Yueshi Guan;Yijie Wang;Wei Wang;Dianguo Xu - 通讯作者:
Dianguo Xu
Cambrian magmatic flare-up, central Tibet: Magma mixing in proto-Tethyan arc along north Gondwanan margin
西藏中部寒武纪岩浆爆发:沿冈瓦南边缘北缘的原特提斯弧中岩浆混合
- DOI:
10.1130/b35859.1 - 发表时间:
2021 - 期刊:
- 影响因子:4.9
- 作者:
Peiyuan Hu;Qingguo Zhai;Peter A. Cawood;Guochun Zhao;Jun Wang;Yue Tang;Zhicai Zhu;Wei Wang;Hao Wu - 通讯作者:
Hao Wu
Spatial resolution comparison of AC-SECM with SECM and their characterization of self-healing performance of hexamethylene diisocyanate trimer microcapsule coatings
AC-SECM与SECM的空间分辨率比较及其对六亚甲基二异氰酸酯三聚体微胶囊涂层自修复性能的表征
- DOI:
10.1039/c5ta00529a - 发表时间:
2015-02 - 期刊:
- 影响因子:11.9
- 作者:
Wei Wang;Likun Xu;Huyuan Sun;Xiangbo Li;Shouhuan Zhao;Weining Zhang - 通讯作者:
Weining Zhang
Application of machine learning algorithms in lane-changing model for intelligent vehicles exiting to off-ramp
机器学习算法在智能车辆驶出匝道换道模型中的应用
- DOI:
10.1080/23249935.2020.1746861 - 发表时间:
2020-04 - 期刊:
- 影响因子:0
- 作者:
Changyin Dong;Hao Wang;Ye Li;Xiaomeng Shi;Daiheng Ni;Wei Wang - 通讯作者:
Wei Wang
Financial development and wage income: Evidence from the global football market
金融发展与工资收入:来自全球足球市场的证据
- DOI:
10.1016/j.jbankfin.2023.106813 - 发表时间:
2023-02 - 期刊:
- 影响因子:3.7
- 作者:
Wei Wang;Haoxi Yang;Xi Wang - 通讯作者:
Xi Wang
Wei Wang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Wei Wang', 18)}}的其他基金
CAREER: Harnessing the Interplay of Morphology, Viscoelasticity, and Surface-Active Agents to Modulate Soft Wetting
职业:利用形态、粘弹性和表面活性剂的相互作用来调节软润湿
- 批准号:
2336504 - 财政年份:2024
- 资助金额:
$ 8.47万 - 项目类别:
Continuing Grant
An Educational Tool for Teaching and Learning Concurrent Computer Programming Techniques
用于教授和学习并行计算机编程技术的教育工具
- 批准号:
2215359 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
Collaborative Research: SHF: Small: Exploiting Performance Correlations for Accurate and Low-cost Performance Testing for Serverless Computing
协作研究:SHF:小型:利用性能相关性对无服务器计算进行准确且低成本的性能测试
- 批准号:
2155096 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
Collaborative Research: EAGER: Enhancing Security and Privacy of Augmented Reality Mobile Applications through Software Behavior Analysis
合作研究:EAGER:通过软件行为分析增强增强现实移动应用程序的安全性和隐私性
- 批准号:
2221843 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
PIPP Phase I: An End-to-End Pandemic Early Warning System by Harnessing Open-source Intelligence
PIPP 第一阶段:利用开源情报的端到端流行病预警系统
- 批准号:
2200274 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
Enhancing Programming and Machine Learning Education for Students with Visual Impairments through the Use of Compilers, AI and Cloud Technologies
通过使用编译器、人工智能和云技术加强对视力障碍学生的编程和机器学习教育
- 批准号:
2202632 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
Collaborative Research: A Bioinspired Approach towards Sustainable Membranes for Resilient Brine Treatment
合作研究:用于弹性盐水处理的可持续膜的仿生方法
- 批准号:
2226501 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
III: Medium: Collaborative Research: Collaborative Machine-Learning-Centric Data Analytics at Scale
III:媒介:协作研究:以机器学习为中心的大规模协作数据分析
- 批准号:
2106859 - 财政年份:2021
- 资助金额:
$ 8.47万 - 项目类别:
Continuing Grant
RAPID: Dynamic Graph Neural Networks for Modeling and Monitoring COVID-19 Pandemic
RAPID:用于建模和监测 COVID-19 大流行的动态图神经网络
- 批准号:
2031187 - 财政年份:2020
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
Collaborative Research; RUI: Non-Orthogonal Multiple Access Pricing for Wireless Multimedia Communications
合作研究;
- 批准号:
2010284 - 财政年份:2020
- 资助金额:
$ 8.47万 - 项目类别:
Standard Grant
相似国自然基金
基于 Direct RNA sequencing 的 RNA 甲基化介导贻贝天然免疫调控的表观遗传机制研究
- 批准号:LR22D060002
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
新型滤波器综合技术-直接综合技术(Direct synthesis Technique)的研究及应用
- 批准号:61671111
- 批准年份:2016
- 资助金额:58.0 万元
- 项目类别:面上项目
相似海外基金
Direct Functionalization of Heteroarenes using Phosphorus
使用磷直接官能化杂芳烃
- 批准号:
2752689 - 财政年份:2022
- 资助金额:
$ 8.47万 - 项目类别:
Studentship
Catalytic Direct Functionalization of Carboxylic Acids by a Transient Protecting Group Strategy
通过瞬态保护基团策略催化直接官能化羧酸
- 批准号:
21K14633 - 财政年份:2021
- 资助金额:
$ 8.47万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Direct functionalization of aromatic rings using temporary dearomatization
使用临时脱芳构化对芳环进行直接官能化
- 批准号:
2605101 - 财政年份:2021
- 资助金额:
$ 8.47万 - 项目类别:
Studentship
Development of Novel Direct Functionalization Methodology of 1,2-Azaborines
1,2-氮杂硼烷的新型直接功能化方法的开发
- 批准号:
20K22522 - 财政年份:2020
- 资助金额:
$ 8.47万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
CAREER: Direct Radical Functionalization of Alcohols using Cobalt Photocatalysis
职业:使用钴光催化对醇进行直接自由基官能化
- 批准号:
1952860 - 财政年份:2019
- 资助金额:
$ 8.47万 - 项目类别:
Continuing Grant
Construction of C–C bonds by direct functionalization of C–H bonds: Trifluoromethylation via dual copper photoredox catalysis
通过 CâH 键直接功能化构建 CâC 键:通过双铜光氧化还原催化进行三氟甲基化
- 批准号:
421436809 - 财政年份:2019
- 资助金额:
$ 8.47万 - 项目类别:
Research Fellowships
Direct functionalization of benzylic C-H bond using pai-benzylpalladium system in water.
使用水中的对-苄基钯体系直接官能化苄基 C-H 键。
- 批准号:
19K07003 - 财政年份:2019
- 资助金额:
$ 8.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Direct Functionalization of Heteroaromatic Compounds Based on Trapping of the Short-lived Carbanions
基于短寿命碳负离子捕获的杂芳族化合物直接官能化的发展
- 批准号:
19H02717 - 财政年份:2019
- 资助金额:
$ 8.47万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of site-selective direct functionalization of aromatic rings by dinuclear palladium catalysts
双核钯催化剂芳环选择性直接官能化的研究进展
- 批准号:
19K05475 - 财政年份:2019
- 资助金额:
$ 8.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CAREER: Direct Radical Functionalization of Alcohols using Cobalt Photocatalysis
职业:使用钴光催化对醇进行直接自由基官能化
- 批准号:
1751687 - 财政年份:2018
- 资助金额:
$ 8.47万 - 项目类别:
Continuing Grant