Phase I IUCRC at Indiana University: Center for Bioanalytic Metrology
印第安纳大学 IUCCRC 第一阶段:生物分析计量中心
基本信息
- 批准号:1916645
- 负责人:
- 金额:$ 75.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-15 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems. Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas generated through collaboration between academia and industry and the delivery of practical pre-competitive knowledge that can drive technology development. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.The CBM is devoted to tackling important measurement science challenges, broadly defined. Some of our members are primarily interested in bioanalytical measurement science, others in problems relating to small molecule pharmaceuticals or agrochemicals, while still others are primarily interested in the analysis of foods, petrochemicals, or materials. The CBM serves these members with research solutions in: (a) ultrahigh sensitivity assays for trace-level biomarkers and impurities; (b) discrimination between large biomolecules and their multi-molecule complexes; (c) reduced volume/materials analysis and experimentation at high throughput and productivity; (d) analysis of rare/extremely dilute cells/molecules/exosomes, etc.; (e) massively parallel approaches to chemical cytometry, genetic profiling, and panel screening; (f) online and near-line in situ measurements; (g) point-of-use analysis, companion diagnostics, and inexpensive testing in the field; (h) AI-driven instrumentation, feedback optimization, and driverless instruments; and (i) enhanced imaging of cells, organisms, and chemical processes. Indiana University contributes distinct expertise in micro/nanoscale analytical separations and measurement, mass spectrometry and/or ion mobility analysis of gas phase ions, computational analysis of multidimensional data, genomics, proteomics, combinatorial molecular biology for new catalysts and reactions, two-dimensional spectroscopic characterization of biomolecules, electrochemical analysis and imaging, and design and construction of instrumentation and electronics to enable new methods of chemical analysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
生物分析计量中心(CBM)是圣母大学、印第安纳大学和普渡大学的合作伙伴关系,通过与工业界合作解决测量科学和技术方面当前、新兴和行业相关的挑战,提高美国的竞争力。该中心有两个总体目标:(1)提供一流的分子测量工具和专业知识,从而在制药、生物技术、食品/营养/农业、能源和分析仪器领域开发强大的新竞争前技术和能力;(2)作为新仪器应用于尖端化学和生化问题的试验场。测量科学和相关仪器是美国经济的关键贡献者,从药物发现到材料制造,它推动了各个领域的进步。通过将这些高科技领域的公司与主要分析仪器制造商聚集在一起,CBM弥合了学术界和工业界合作产生的新想法的初步演示与可推动技术发展的实用竞争前知识的交付之间的差距。同样重要的是,CBM为美国工业界提供了极具吸引力的机会,通过接触各种中心培训的学生和对现有员工进行继续教育的机会,来振兴人力资源。CBM致力于解决广泛定义的重要测量科学挑战。我们的一些成员主要对生物分析测量科学感兴趣,其他成员主要对与小分子药物或农用化学品有关的问题感兴趣,而还有一些成员主要对食品,石化产品或材料的分析感兴趣。CBM为这些成员提供以下研究解决方案:(a)对痕量生物标志物和杂质的超高灵敏度分析;(b)辨别大分子及其多分子复合物;(c)在高通量和生产率下减少体积/材料分析和实验;(d)稀有/极稀细胞/分子/外泌体等分析;(e)化学细胞术、基因图谱和小组筛选的大规模并行方法;(f)在线和近线现场测量;(g)使用点分析、伴随诊断和现场廉价检测;(h) ai驱动仪器、反馈优化、无人驾驶仪器;(1)增强细胞、生物体和化学过程的成像。印第安纳大学在微/纳米级分析分离和测量、质谱和气相离子的离子迁移分析、多维数据的计算分析、基因组学、蛋白质组学、新催化剂和反应的组合分子生物学、生物分子的二维光谱表征、电化学分析和成像等方面贡献了独特的专业知识。设计和建造仪器和电子设备,使化学分析的新方法成为可能。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Modelling virus contact mechanics under atomic force imaging conditions
- DOI:10.1080/00036811.2022.2044027
- 发表时间:2021-12
- 期刊:
- 影响因子:1.1
- 作者:Paolo Piersanti;Kristen L. White;B. Dragnea;R. Temam
- 通讯作者:Paolo Piersanti;Kristen L. White;B. Dragnea;R. Temam
Characterization of Classical Vaccines by Charge Detection Mass Spectrometry
- DOI:10.1021/acs.analchem.1c01893
- 发表时间:2021-08-26
- 期刊:
- 影响因子:7.4
- 作者:Miller, Lohra M.;Bond, Kevin M.;Jarrold, Martin F.
- 通讯作者:Jarrold, Martin F.
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Stephen Jacobson其他文献
EXTERNALISM AND ACTION-GUIDING EPISTEMIC NORMS
外在主义和行动指导认知规范
- DOI:
10.1023/a:1004941211847 - 发表时间:
1997 - 期刊:
- 影响因子:1.5
- 作者:
Stephen Jacobson - 通讯作者:
Stephen Jacobson
Successful Leadership for Improved Student Learning in High Needs Schools: U.S. Perspectives from the International Successful School Principalship Project (ISSPP)
提高高需求学校学生学习的成功领导力:国际成功学校校长项目 (ISSPP) 的美国视角
- DOI:
10.1007/978-94-007-1350-5_31 - 发表时间:
2011 - 期刊:
- 影响因子:1.3
- 作者:
Stephen Jacobson;Lauri Johnson - 通讯作者:
Lauri Johnson
Social Justice Leadership for Academic, Organisational and Community Sustainability in High-Needs Schools: Evidence from New Zealand, Belize and the USA
高需求学校学术、组织和社区可持续发展的社会正义领导力:来自新西兰、伯利兹和美国的证据
- DOI:
10.1007/978-3-030-10874-8_2 - 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Stephen Jacobson - 通讯作者:
Stephen Jacobson
Preparing School Leaders to Lead Organizational Learning and Capacity Building
帮助学校领导做好领导组织学习和能力建设的准备
- DOI:
10.1007/978-94-007-0542-5_6 - 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Stephen Jacobson;O. Johansson;C. Day - 通讯作者:
C. Day
Subsequent prostate cancer detection in patients with prostatic intraepithelial neoplasia or atypical small acinar proliferation.
前列腺上皮内瘤变或非典型小腺泡增殖患者的后续前列腺癌检测。
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
M. Amin;S. Jeyaganth;N. Fahmy;L. Bégin;S. Aronson;Stephen Jacobson;S. Tanguay;A. Aprikian - 通讯作者:
A. Aprikian
Stephen Jacobson的其他文献
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{{ truncateString('Stephen Jacobson', 18)}}的其他基金
REU Site: Nanoscale Assembly of Molecules and Materials at Indiana University
REU 站点:印第安纳大学分子和材料的纳米级组装
- 批准号:
1460720 - 财政年份:2015
- 资助金额:
$ 75.1万 - 项目类别:
Standard Grant
In-Plane Nanofluidic Devices for Particle Characterization
用于颗粒表征的平面纳流体装置
- 批准号:
1308484 - 财政年份:2013
- 资助金额:
$ 75.1万 - 项目类别:
Standard Grant
MRI: Acquisition of a Focused Ion Beam Instrument for Research and Education
MRI:购买用于研究和教育的聚焦离子束仪器
- 批准号:
0923064 - 财政年份:2009
- 资助金额:
$ 75.1万 - 项目类别:
Standard Grant
Nanofluidic Devices for AC Electrokinetic Trapping and Separation
用于交流动电捕获和分离的纳流体装置
- 批准号:
0750295 - 财政年份:2008
- 资助金额:
$ 75.1万 - 项目类别:
Continuing Grant
Collaborative Research: Architecture and Prototype for a Programmable Lab-on-a-Chip
合作研究:可编程片上实验室的架构和原型
- 批准号:
0726694 - 财政年份:2007
- 资助金额:
$ 75.1万 - 项目类别:
Continuing Grant
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