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Homogeneous synthesis and nano-structuring of novel zwitterionic polysaccharid carbamates

新型两性离子多糖氨基甲酸酯的均相合成和纳米结构

基本信息

批准号：
238510265
负责人：
Professor Dr. Thomas Heinze
金额：
--
依托单位：
Institut für Organische Chemie und Makromolekulare Chemie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/238510265?language=en
关键词：
Homogeneous synthesis nano structuring novel

项目摘要

The aim of the project is the synthesis and characterization of novel zwitterionic structures based on the biopolymers cellulose, starch and dextran. Due to the high efficiency and sustainability of ionic liquids, we will focus on homogenous conversions in these reaction media. The aminolysis of polysaccharide carbonates represents a universal synthesis strategy yielding zwitterionic biopolymers. Introduction of oppositely charged groups in the polymer backbone is realized by reactions with functional amines. The structure of the derivatives obtained will be characterized by means of modern methods of polysaccharide analytics (in particular NMR spectroscopy including multidimensional methods, MALDI-TOF, GPC). Beyond the investigation of the polymers, measurements on compounds of comparatively low molecular weight will be carried out in order to study polysaccharide carbonates and their corresponding carbamates in detail. For example, information about substitution patterns can be obtained. Moreover, the formation of supra-molecular architectures of the products depending on external stimuli, e. g. pH value, temperature, and concentration of salt, will be studied. Polymeric layers could be characterized by means of Atomic Force Microscopy (AFM), X-ray Photoelectron Spectroscopy (XPS) and tensiometry. The nanoparticles obtained will be analyzed by a Particle Size Distribution Analyzer (PSDA) and Dynamic Light Scattering (DLS). Furthermore, we will conclude on structure-property-relationships. With regard to potential applications in fields of antibioadherent films or carrier systems for proteins the interactions of the nanostructures with living cells is of interest and should be carried out.

该项目的目的是基于生物聚合物纤维素、淀粉和葡聚糖的新型两性离子结构的合成和表征。由于离子液体的高效性和可持续性，我们将专注于这些反应介质中的均相转化。多糖碳酸酯的氨解代表了产生两性离子生物聚合物的通用合成策略。在聚合物主链中引入带相反电荷的基团是通过与官能胺反应实现的。所获得的衍生物的结构将通过多糖分析的现代方法（特别是NMR光谱法，包括多维方法、MALDI-TOF、GPC）来表征。除了对聚合物的研究之外，还将对相对低分子量的化合物进行测量，以详细研究多糖碳酸酯及其相应的氨基甲酸酯。例如，可以获得关于替代模式的信息。此外，产物的超分子结构的形成依赖于外部刺激，例如。G. pH值，温度和盐的浓度，将进行研究。聚合物层可以通过原子力显微镜（AFM）、X射线光电子能谱（XPS）和张力测定法来表征。将通过粒度分布分析仪（PSDA）和动态光散射（DLS）分析获得的纳米颗粒。此外，我们将总结结构-性质-关系。关于在蛋白质的粘附膜或载体系统领域中的潜在应用，纳米结构与活细胞的相互作用是令人感兴趣的，并且应该进行。