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Self-assembling Polysaccharide Polyelectrolytes

自组装多糖聚电解质

基本信息

批准号：
49496154
负责人：
Professor Dr. Thomas Heinze
金额：
--
依托单位：
Institut für Organische Chemie und Makromolekulare Chemie
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2007
资助国家：
德国
起止时间：
2006-12-31 至 2009-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/49496154?language=en
关键词：
Self assembling Polysaccharide Polyelectrolytes

项目摘要

Our goal is to understand how charge regulation in polysaccharide systems affects self-assembly and to use this knowledge to create nanostructured systems that mimic nature and expand the application domain of polysaccharides in fields of drug delivery, wound treatment, and tissue engineering. The project will combine expertise in polysaccharide synthesis and modification, cellulose nanocrystal preparation and characterization, and surface modification and characterization. The German part is the design of water soluble/disperable polysaccharides from xylan and other hemicelluloses from different sources, and curdlan and pullulan as model compound, with ionic substituents and hydrophobic cinnamoyl or cinnamyl photocrosslinking groups for thin film formation structures through layer-by-layer assembly. For this purpose, novel synthesis paths to polysaccharide cationic derivatives (hydroxypropyltrimethylammonium, dialkylammoniumethyl derivatives) and anionic ones (carboxymethyl or sulfur acid half ester derivatives) and cinnamoyl esters and cinnamyl ethers are aspired by control of the degree of substitution (DS) and hence charge density, and the distribution of the functions within the repeating unit and along the polymer chain applying dissolved or swollen polymers vs. conventional paths for synthesis of polysaccharide polyelectrolyte derivatives. The polysaccharide polyelectrolytes are characterized by means of one- and two dimensional NMR, SEC, and HPLC techniques after acidic or enzymatic chain degradation to get a comprehensive structure information.

我们的目标是了解多糖系统中的电荷调节如何影响自组装，并利用这些知识来创建模仿自然的纳米结构系统，并扩展多糖在药物输送，伤口治疗和组织工程领域的应用领域。该项目将结合联合收割机在多糖合成和改性、纤维素酶制备和表征以及表面改性和表征方面的专业知识。德国部分是设计水溶性/分散性多糖，其来源于不同来源的木聚糖和其他半纤维素，并以可得多糖和支链淀粉为模型化合物，具有离子取代基和疏水性肉桂酰基或肉桂酰基光交联基团，通过层层组装形成薄膜结构。为此目的，多糖阳离子衍生物的新合成途径（羟丙基三甲基铵，二烷基铵甲基衍生物）和阴离子型（羧甲基或硫酸半酯衍生物）和肉桂酰基酯和肉桂基醚通过控制取代度（DS）并因此控制电荷密度来实现，和官能团在重复单元内和沿着聚合物链的分布，应用溶解或溶胀的聚合物与常规的合成多糖的途径相比，衍生物.多糖聚电解质在酸或酶降解后通过一维和二维NMR、SEC和HPLC技术表征，以获得全面的结构信息。