Meltable Biopolymers with magnetic micro segments

具有磁性微段的可熔生物聚合物

• 批准号: 392158889
• 负责人: Professor Dr. Thomas Heinze
• 金额: --
• 依托单位: Leibniz-Institut für Photonische Technologien (IPHT)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/392158889?language=en
• 关键词: Meltable; Biopolymers; magnetic; micro; segments

Novel meltable and magnetic biomaterials will be studied that contain defined distribution pattern and segments of magnetic nanoparticles. Biopolymers with adjustable melting points are synthesized by esterification of the polysaccharides with fatty acids. Additionally, unsaturated functional groups are introduced that can be photochemically crosslinked, on one hand. On the other, functions that enable a reversible cross-linking are in the center of interest. In particular, systems allowing Diels-Alder and retro-Diels-Alder reactions will be investigated. These reversible and irreversible meltable biopolymer derivatives can be loaded with magnetic nanoparticles. A locally limited, induced crosslinking of the polymer matrix is carried out on the magnetically doped materials. Through the crosslinking, substructures can be created in the material that have a barrier effect. During thermal treatment, these barriers have a significantly higher viscosity or do not melt at all. By interaction of the molten matrix with an external magnetic field gradient, the magnetic particles migrate to the segment boundary and concentrate there. This allows the magnetic nanoparticles to be specifically directed through the molten matrix. In this way, multiple magnetic gradients can be generated in the biopolymer matrix having a distribution pattern of the magnetic nanoparticles that is predetermined by the crosslinking. Studies on viscosity and particle motion will show how the barrier effect and how the formation of the segments can be controlled. A mathematical model for the mobility of nanoparticles in the novel systems will be developed from the data for this particle-matrix interaction. The melting behavior in the alternating magnetic field is investigated on solid biopolymers with magnetic microsegments. The possibility of using these biopolymers in micro-technological systems such as actuators will be investiaged.

将研究包含磁性纳米颗粒的明确分布模式和片段的新型可熔融磁性生物材料。通过多糖与脂肪酸的酯化反应，合成了熔点可调的生物聚合物。此外，还引入了光化学交联的不饱和官能团。另一方面，实现可逆交联的功能是研究的中心。特别是，允许Diels-Alder反应和反Diels-Alder反应的系统将被研究。这些可逆和不可逆的可熔融生物聚合物衍生物可以装载磁性纳米颗粒。在磁掺杂材料上进行了局部受限的聚合物基体诱导交联。通过交联，可以在材料中产生具有阻隔效应的子结构。在热处理过程中，这些屏障具有明显更高的粘度或根本不熔化。通过熔融基体与外加磁场梯度的相互作用，磁性颗粒向管段边界迁移并在此集中。这使得磁性纳米颗粒能够被定向穿过熔融基质。通过这种方式，可以在生物聚合物基质中产生多个磁梯度，具有通过交联预先确定的磁性纳米颗粒的分布模式。对粘度和颗粒运动的研究将表明如何控制屏障效应以及如何控制段的形成。将从这种粒子-基质相互作用的数据中发展出纳米颗粒在新系统中的迁移率的数学模型。研究了具有磁性微段的固体生物聚合物在交变磁场中的熔化行为。将研究这些生物聚合物在微技术系统（如执行器）中的应用可能性。