Meltable Biopolymers with magnetic micro segments

新型可熔磁性生物材料将被研究，其中包含定义的分布模式和磁性纳米粒子的片段。通过多糖与脂肪酸的酯化反应合成具有可调熔点的生物聚合物。另外，一方面，引入了可以光化学交联的不饱和官能团。另一方面，能够实现可逆交联的功能是感兴趣的中心。特别地，将研究允许Diels-桤木和逆Diels-桤木反应的系统。这些可逆和不可逆的可熔融生物聚合物衍生物可以负载有磁性纳米颗粒。在磁性掺杂材料上进行聚合物基质的局部限制的诱导交联。通过交联，可以在材料中产生具有阻隔效果的子结构。在热处理期间，这些屏障具有显著更高的粘度或根本不熔化。通过熔融基质与外部磁场梯度的相互作用，磁性颗粒迁移到片段边界并在那里聚集。这允许磁性纳米颗粒被特定地引导通过熔融基质。以这种方式，可以在生物聚合物基质中产生多个磁梯度，所述生物聚合物基质具有通过交联预定的磁性纳米颗粒的分布图案。对粘度和颗粒运动的研究将表明如何控制屏障效应和链段的形成。纳米粒子在新系统中的流动性的数学模型将开发从这种粒子-基质相互作用的数据。研究了含磁性微段的固体生物高分子在交变磁场中的熔融行为。将研究在微技术系统如致动器中使用这些生物聚合物的可能性。

Novel meltable and magnetic biomaterials will be studied that contain defined distribution pattern and segments of magnetic nanoparticles. Biopolymers with adjustable melting points are synthesized by esterification of the polysaccharides with fatty acids. Additionally, unsaturated functional groups are introduced that can be photochemically crosslinked, on one hand. On the other, functions that enable a reversible cross-linking are in the center of interest. In particular, systems allowing Diels-Alder and retro-Diels-Alder reactions will be investigated. These reversible and irreversible meltable biopolymer derivatives can be loaded with magnetic nanoparticles. A locally limited, induced crosslinking of the polymer matrix is carried out on the magnetically doped materials. Through the crosslinking, substructures can be created in the material that have a barrier effect. During thermal treatment, these barriers have a significantly higher viscosity or do not melt at all. By interaction of the molten matrix with an external magnetic field gradient, the magnetic particles migrate to the segment boundary and concentrate there. This allows the magnetic nanoparticles to be specifically directed through the molten matrix. In this way, multiple magnetic gradients can be generated in the biopolymer matrix having a distribution pattern of the magnetic nanoparticles that is predetermined by the crosslinking. Studies on viscosity and particle motion will show how the barrier effect and how the formation of the segments can be controlled. A mathematical model for the mobility of nanoparticles in the novel systems will be developed from the data for this particle-matrix interaction. The melting behavior in the alternating magnetic field is investigated on solid biopolymers with magnetic microsegments. The possibility of using these biopolymers in micro-technological systems such as actuators will be investiaged.