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PFI-TT: Affordable and High-Quality Polyethylene Glycols for Nanomedicine and Other Applications

PFI-TT：用于纳米医学和其他应用的经济实惠的高质量聚乙二醇

基本信息

批准号：
1918585
负责人：
Shiyue Fang
金额：
$ 25万
依托单位：
Michigan Technological University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1918585&HistoricalAwards=false
关键词：
PFI TT Affordable Quality Polyethylene

项目摘要

The broader impact/commercial potential of this Partnerships for Innovation (PFI) project is the development of a new way to make a special class of chemicals, polyethylene glycols (PEGs). PEGs are neutral, stable, flexible, non-toxic and dissolve easily, and thus they are used in many applications, including pharmaceutical products and other biomedical applications. However, it is difficult to make PEGs with enough purity and consistency for use in more advanced pharmaceutical applications, and for other uses, the right PEG simply cannot be made. This PFI project will develop and commercialize novel ways to synthesize PEGs. The new affordable and highly pure PEGs will generate higher quality and lower prices for drugs using them; similarly, many biomedical and related research projects requiring PEGs will be more affordable and will generate more consistent results.The proposed project will advance the knowledge needed for the synthesis of highly pure PEGs with affordable prices. Currently, pure PEGs shorter than those with 64 ethylene glycol monomer units can be synthesized, but the methods require multiple expensive reaction workups and chromatography, and the products have limited purity. In addition, pure PEGs longer than 64 ethylene glycol monomer units with acceptable purity cannot be synthesized using any known methods. The technical hurdles that cause these problems of PEG synthesis include the difficulty to separate PEG products and impurities, slow reaction rates, and depolymerization side reactions. The research objective of this project is to gain the knowledge needed to overcome these technical hurdles. The approaches include using solid phase synthesis instead of traditional solution phase synthesis, innovative stepwise synthesis monomers, and automated synthesis using a peptide synthesizer. Using these approaches, the products will be easily isolated without tedious workup and purified without expensive chromatography, the reaction rates will be increased, the depolymerization side reaction will be suppressed, and the process will require minimal labor. It is expected that once detailed knowledge about using these approaches are obtained, pure PEGs with unprecedented high quality and low costs will be conveniently produced.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个创新伙伴关系（PFI）项目的更广泛的影响/商业潜力是开发一种新的方法来制造一类特殊的化学品，聚乙二醇（PEG）。 PEG是中性的，稳定的，柔性的，无毒的并且容易溶解，因此它们被用于许多应用，包括医药产品和其他生物医学应用。然而，很难制造具有足够纯度和一致性的PEG以用于更先进的制药应用，并且对于其他用途，根本无法制造正确的PEG。这个PFI项目将开发和商业化合成PEG的新方法。新的可负担得起的高纯度PEG将为使用它们的药物带来更高的质量和更低的价格;同样，许多需要PEG的生物医学和相关研究项目将更加负担得起，并将产生更一致的结果。拟议的项目将推进以可负担的价格合成高纯度PEG所需的知识。目前，可以合成比具有64个乙二醇单体单元的那些短的纯PEG，但是该方法需要多次昂贵的反应后处理和色谱法，并且产物具有有限的纯度。此外，具有可接受纯度的长于64个乙二醇单体单元的纯PEG不能使用任何已知方法合成。导致PEG合成的这些问题的技术障碍包括难以分离PEG产物和杂质、缓慢的反应速率和解聚副反应。该项目的研究目标是获得克服这些技术障碍所需的知识。这些方法包括使用固相合成代替传统的液相合成，创新的逐步合成单体，以及使用肽合成仪的自动化合成。使用这些方法，产物将容易地分离而无需繁琐的后处理，并且无需昂贵的色谱法而纯化，反应速率将增加，解聚副反应将被抑制，并且该方法将需要最少的劳动。预计一旦获得有关使用这些方法的详细知识，将方便地生产出具有前所未有的高质量和低成本的纯PEG。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。