MRI: Acquisition of a High Resolution Low Voltage Electron Microscope for Multidisciplinary Needs at The University of Georgia

MRI：佐治亚大学采购高分辨率低压电子显微镜以满足多学科需求

• 批准号: 1919942
• 负责人: Tina Salguero
• 金额: $ 99.75万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919942&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Low; Voltage

This Major Research Instrumentation (MRI) award supports the acquisition of a high-resolution low-voltage electron microscope at the University of Georgia (UGA) that enables the research, training, teaching, and outreach efforts of investigators across the physical sciences, geological and environmental sciences, biological sciences, engineering disciplines, and allied fields. The unique technical capabilities of this microscope allow the imaging and chemical analysis of samples under conditions that mitigate electron beam damage. These capabilities lead to the study of diverse materials including nanostructures, polymers, fibers, and biological specimens, which encompass research being done by 29 major users across numerous colleges, centers, departments, and laboratories at UGA. This instrument is integrated within the Georgia Electron Microscopy (GEM) core facility at UGA to permit inter- and transdisciplinary usage and collaboration. Beyond research applications and the associated training of student users, the new microscope enables the inclusion of state-of-the-art electron microscopy content in course offerings and outreach efforts. These activities are accomplished in part using GEM's Electron Theater, with an emphasis on nanoscience in the environment. In addition, the instrument is used to acquire data sets suitable for integration into K-12 STEM lesson plans.This MRI award supports the acquisition of an electron microscope capable of low-voltage operation (defined as less than or equal to 30 kV). The technical highlights of this instrument include ultra high-resolution scanning electron microscopy (UHR-SEM) imaging at low voltages; high resolution scanning transmission electron microscopy (STEM) mode, including high-angle annular dark field (HAADF) imaging and additional detectors, all operating at a low beam voltage; and analytical tools that provide quantitative composition and structure data, including electron diffraction, elemental mapping by energy dispersive X-ray spectroscopy (EDS), and electron energy-loss spectroscopy (EELS), all at low voltages. Research projects enabled by this instrument span four thematic areas: (1) inorganic nanomaterials, especially 2D nanosheets and functional materials for energy storage, electronics applications, biomedical imaging, and drug delivery applications, (2) nanogeoscience and environmental soil science, (3) new frontiers in developing high-resolution low-voltage methods for imaging biological specimens, and (4) high-resolution low-voltage imaging of nanostructured hybrid systems and soft materials, including beam-sensitive samples like polymers and fibers. In particular, the application of electron microscopy to beam-sensitive materials will provide new detailed information about sample composition, heterogeneity, structure, phase purity, and properties at the nanoscale. Additionally, the superior contrast in STEM brightfield and HAADF imaging modes, compared with TEM imaging, will allow investigators to resolve detailed organic components, such as the ligand coronas of inorganic nanostructures and interfaces between biological structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个主要的研究仪器（MRI）奖支持在佐治亚大学（UGA）的高分辨率低压电子显微镜的收购，使研究，培训，教学，并在整个物理科学，地质和环境科学，生物科学，工程学科和相关领域的研究人员的推广工作。该显微镜的独特技术能力允许在减轻电子束损伤的条件下对样品进行成像和化学分析。这些能力导致不同的材料，包括纳米结构，聚合物，纤维和生物标本的研究，其中包括由29个主要用户在众多学院，中心，部门和实验室在UGA正在做的研究。该仪器集成在佐治亚电子显微镜（GEM）核心设施在UGA允许跨学科和跨学科的使用和协作。除了研究应用和对学生用户的相关培训之外，新的显微镜还可以在课程设置和推广工作中包含最先进的电子显微镜内容。这些活动部分是通过GEM的电子剧场完成的，重点是环境中的纳米科学。此外，该仪器还用于获取适合整合到K-12 STEM课程计划中的数据集。该MRI奖支持获得能够低压操作的电子显微镜（定义为小于或等于30kv）。该仪器的技术亮点包括超低电压下的超高分辨率扫描电子显微镜（UHR-SEM）成像；高分辨率扫描透射电子显微镜（STEM）模式，包括高角度环形暗场（HAADF）成像和额外的探测器，全部在低光束电压下工作；以及提供定量成分和结构数据的分析工具，包括电子衍射、能量色散x射线能谱（EDS）的元素映射和电子能量损失能谱（EELS），所有这些都是在低电压下进行的。该工具支持的研究项目涵盖四个主题领域：(1)无机纳米材料，特别是用于储能、电子应用、生物医学成像和药物输送应用的二维纳米片和功能材料；(2)纳米地球科学和环境土壤科学；(3)开发用于生物标本成像的高分辨率低压方法的新领域；(4)纳米结构混合系统和软材料的高分辨率低压成像，包括聚合物和纤维等光束敏感样品。特别是，电子显微镜在光束敏感材料上的应用将提供关于样品组成、非均质性、结构、相纯度和纳米级性能的新的详细信息。此外，与TEM成像相比，STEM亮场和HAADF成像模式的优越对比度将使研究人员能够解析详细的有机成分，例如无机纳米结构的配体冠和生物结构之间的界面。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Localized alteration of ferrihydrite natural organic matter coprecipitates following reaction with Fe(II)

水铁矿天然有机物与 Fe(II) 反应后共沉淀的局部变化

• DOI: 10.1002/saj2.20366
• 发表时间: 2022
• 期刊: Soil Science Society of America Journal
• 影响因子: 2.9
• 作者: Noor, Nadia;Thompson, Aaron
• 通讯作者: Thompson, Aaron

Combining Doxorubicin-Conjugated Polymeric Nanoparticles and 5-Aminolevulinic Acid for Enhancing Radiotherapy against Lung Cancer

结合阿霉素缀合的聚合物纳米颗粒和 5-氨基乙酰丙酸以增强肺癌放射治疗

• DOI: 10.1021/acs.bioconjchem.2c00066
• 发表时间: 2022-04-20
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Han, Jinghua;Yang, Wei;Huang, Xinglu
• 通讯作者: Huang, Xinglu

Catalytic Esterification Using Solid Acid Carbon Catalysts Synthesized by Sustainable Hydrothermal and Plasma Sulfonation Techniques

• DOI: 10.1021/acs.iecr.2c00086
• 发表时间: 2022-03
• 期刊: Industrial & Engineering Chemistry Research
• 作者: Sarada Sripada;J. Kastner

Achieving enhanced peroxidase-like activity in multimetallic nanorattles

在多金属纳米摇铃中实现增强的过氧化物酶样活性

• DOI: 10.1039/d2dt02389j
• 发表时间: 2022
• 期刊: Dalton Transactions
• 影响因子: 4
• 作者: da Silva, Flavia G.;Formo, Eric V.;Camargo, Pedro H.
• 通讯作者: Camargo, Pedro H.

Direct nanoscale observations of degassing-induced crystallisation in felsic magmas

长英质岩浆脱气诱导结晶的直接纳米尺度观察

• DOI: 10.1007/s00410-022-01900-1
• 发表时间: 2022
• 期刊: Contributions to Mineralogy and Petrology
• 影响因子: 3.5
• 作者: Pistone, Mattia;Formo, Eric;Whittington, Alan G.;Herbst, Thomas;Cottrell, Elizabeth
• 通讯作者: Cottrell, Elizabeth