DMREF: Collaborative Research: Digital Magnetic Handshake Materials, Structures, and Machines

DMREF：合作研究：数字磁握手材料、结构和机器

• 批准号: 1921619
• 负责人: Michael Brenner
• 金额: $ 63.94万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1921619&HistoricalAwards=false
• 关键词: DMREF; Collaborative; Research; Digital; Magnetic

Non-technical Description: Manufacturing of complex objects is the key engine of technological progress. Learning to build smart, digital, and mechanically functional objects at the microscale could be as revolutionary as human-scale manufacturing. This grant will support research to develop a new way of meeting this challenging goal. It combines two technologies: modern magnetic information storage, which can create tiny magnets in any pattern desired, and ultrathin flexible materials that can bend in response to tiny forces. These will be combined with the design principles of colloidal systems, polymer physics, and molecular biology to create intelligent, functional objects, machines, and materials. The pieces will interact in a way analogous to the way DNA bases bind together, with magnets playing the role of the base pairs, and the thin materials playing the role of the DNA backbone. The magnetic information will determine how multiple strands connect and form complex structures and micron sized machines that can be controlled with external magnetic fields. These materials will ultimately have fundamental impacts on micro-engineering, with a range of potential applications, from materials to medicine. As such, this research will promote the progress of science and ultimately benefit the US economy and society. This research borrows concepts from a variety of fields - a multi-disciplinary approach that will help broaden participation of underrepresented groups in research and positively impact engineering and science education. For example, macroscopic analogs will be adopted into lending kits that will be used to explain the basic principles behind base paring in DNA and its assembly into DNA origami structures to impoverished communities in upper Appalachia. Technical Description: This grant will support research aimed at building a new platform for self-assembly that uses panels with magnetic handshakes - microscopic patterns of magnetic dipoles - that enable panels to bond together using specific, intelligent interactions analogous to Watson-Crick base pairs in DNA. By fabricating these panels on nm thin elastic strands grown via atomic layer deposition, the panel sequence will determine how multiple strands connect to one another and form complex untethered structures and micron sized machines that can be manipulated with external magnetic fields. These handshake panels will be programmed using either magneto-optic recording (micron scale) or commercial scanned magnetic write head (50 nm scale). The resulting magnetic colloids, strands, or nets will be released from the substrate into solution, and allowed to bend, move, and assemble according to their designed interactions. The approach of the grant is to integrate design, macroscale models, advanced simulations, and experiment, to master the programmed self-assembly of these magnetic handshake materials. Overall, this strategy both takes advantage of the complementary binding principle behind current state of the art 3D DNA based assembly and overcomes many of its limitations, including vastly expanding the range of operating parameters such as temperature, solvent, etc. The resulting structures can be fully integrated with other lithographic elements (electronics, optics, etc.) and will have broad applications in sensing, actuation, and microrobotics at the cellular scale.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术描述：复杂物体的制造是技术进步的关键引擎。学习在微尺度上建造智能、数字和机械功能的物体可能与人类规模的制造一样具有革命性。这笔赠款将支持研究开发一种新的方式来实现这一具有挑战性的目标。它结合了两种技术：现代磁信息存储技术，它可以产生任何所需图案的微小磁体，以及可以响应微小力而弯曲的柔性材料。这些将与胶体系统，聚合物物理学和分子生物学的设计原理相结合，以创造智能，功能性的物体，机器和材料。这些片段将以类似于DNA碱基结合在一起的方式相互作用，磁体扮演碱基对的角色，而薄材料扮演DNA骨架的角色。磁性信息将决定多股如何连接并形成复杂的结构和可以用外部磁场控制的微米大小的机器。这些材料最终将对微工程产生根本性的影响，具有从材料到医学的一系列潜在应用。因此，这项研究将促进科学的进步，最终造福美国经济和社会。这项研究借鉴了各个领域的概念-一种多学科的方法，将有助于扩大代表性不足的群体在研究中的参与，并对工程和科学教育产生积极影响。例如，宏观类似物将被采用到出借工具包中，这些工具包将用于向上阿巴拉契亚的贫困社区解释DNA中碱基配对及其组装成DNA折纸结构的基本原理。 技术说明：这笔赠款将支持旨在建立一个新的自组装平台的研究，该平台使用具有磁握手的面板-磁偶极子的微观模式-使面板能够使用类似于DNA中沃森-克里克碱基对的特定智能相互作用结合在一起。通过在经由原子层沉积生长的纳米薄弹性股线上制造这些面板，面板序列将确定多个股线如何彼此连接并形成复杂的无束缚结构和可以用外部磁场操纵的微米尺寸的机器。这些握手面板将使用磁光记录（微米级）或商业扫描磁写头（50纳米级）进行编程。所得到的磁性胶体、股线或网将从基底释放到溶液中，并允许其根据其设计的相互作用弯曲、移动和组装。该资助的方法是整合设计，宏观模型，高级模拟和实验，以掌握这些磁性握手材料的程序化自组装。总的来说，这种策略既利用了当前基于3D DNA的组装技术的互补结合原理，又克服了其许多局限性，包括极大地扩展了操作参数的范围，如温度、溶剂等。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。