Collaborative Research: NCS-FO Biology and Function of Prosody: Integrative approach to individual differences

合作研究：NCS-FO 生物学和韵律功能：个体差异的综合方法

• 批准号: 1926794
• 负责人: Reyna Gordon
• 金额: $ 60.66万
• 依托单位: Vanderbilt University Medical Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1926794&HistoricalAwards=false
• 关键词: Collaborative; Research; NCS; FO; Biology

College readiness and career opportunities are highly dependent on young adults' reading proficiency. Yet, recent data indicate that almost two-thirds of tested students, including many students with dyslexia, do not possess the fundamental skills that are required to successfully master college-level reading material. Prosody, defined as linguistically relevant fluctuations in intonation, stress and timing, is an essential but underappreciated aspect of spoken language and reading. Humans vary in their sensitivity to the prosodic structure of speech, and there appears to be a strong link to individual differences in reading skills. With the support of the Integrative Strategies in Neural and Cognitive Systems program, this project will take bold steps towards investigating the biology and function of prosody with a creative array of approaches and research settings. With the first-ever dataset of its kind, the project intends to make critical progress towards integrating knowledge from a large population sample about the neurobiological basis of prosody across methods and levels (genetics, neuroimaging, and behavioral task performance). Beyond scientific advancement, the activities outlined in the proposed project will allow the research team to contribute to improving STEM education and educator development, addressing neurodevelopmental disorders such as dyslexia, increasing public engagement with science and technology, and enhancing big-data partnerships across academic sites.The underlying biology of prosody is poorly understood at the neural and genetic level, despite its important function in humans' communication skills. Innovative combinations of multi-disciplinary approaches for novel data collection in large samples and use of existing large-scale resources are needed to yield significant knowledge of the biology and function of prosody. The first aim of this proposal will include a series of studies using a combination of EEG, eye tracking and standardized behavioral tasks to explore the time-dynamic processes of attending to prosodic cues in ecologically valid situations of speech perception and reading, and to examine the contribution of prosody sensitivity to individual differences in reading. The second aim will be a genome-wide association study of prosodic sensitivity and will be conducted through a diverse sample of individuals recruited online throughout the United States and in-person in the Middle Tennessee area in local community and educational settings. Cutting-edge genomic methodologies (PrediXcan and Gene Set Enrichment analysis) will be used to identify the genetic markers and novel neural endophenotypes (imputed gene expression in brain tissue) that give rise to individual differences in prosody. This series of studies builds essential groundwork for future planned studies that seek to disentangle shared versus separate genetic architecture of prosody and other aspects of language function and could reveal transformative knowledge about the biological mechanisms driving individual differences in reading and language skill. The collaborative research project leverages the team?s diverse backgrounds in Cognitive Neuroscience, Psycholinguistics, Communication Disorders, and Human Genetics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

大学准备和就业机会高度依赖于年轻人的阅读能力。然而，最近的数据表明，近三分之二的受测学生，包括许多患有阅读障碍的学生，不具备成功掌握大学水平阅读材料所需的基本技能。韵律，被定义为与语言相关的语调、重音和时间的波动，是口语和阅读的一个重要但未被重视的方面。人类对语言韵律结构的敏感度各不相同，这似乎与阅读技能的个体差异有很强的联系。在神经和认知系统综合策略项目的支持下，该项目将采取大胆的步骤，通过一系列创造性的方法和研究环境来研究韵律的生物学和功能。凭借首个此类数据集，该项目旨在跨方法和层面（遗传学、神经成像和行为任务表现）整合来自大量人口样本的关于韵律神经生物学基础的知识，取得关键进展。除了科学进步之外，拟议项目中概述的活动将使研究团队能够为改善STEM教育和教育工作者的发展做出贡献，解决阅读障碍等神经发育障碍，增加公众对科学技术的参与，并加强学术站点之间的大数据合作关系。尽管韵律在人类的沟通技巧中起着重要的作用，但在神经和遗传水平上，人们对韵律的潜在生物学知之甚少。需要将多学科方法创新地结合起来，在大样本中收集新的数据，并利用现有的大规模资源，以获得有关韵律生物学和功能的重要知识。本研究的第一个目标将包括一系列结合脑电图、眼动追踪和标准化行为任务的研究，以探索在语音感知和阅读的生态有效情况下关注韵律线索的时间动态过程，并检查韵律敏感性对阅读个体差异的贡献。第二个目标将是韵律敏感性的全基因组关联研究，并将通过在美国各地在线招募的不同个体样本和在田纳西州中部地区当地社区和教育机构中亲自进行。尖端的基因组方法（PrediXcan和基因集富集分析）将用于鉴定导致韵律个体差异的遗传标记和新的神经内表型（脑组织中输入的基因表达）。这一系列研究为未来的计划研究奠定了基础，这些计划研究旨在解开韵律和语言功能其他方面的共同遗传结构与单独遗传结构的关系，并可能揭示有关驱动阅读和语言技能个体差异的生物机制的变革知识。合作研究项目利用了团队？他在认知神经科学、心理语言学、沟通障碍和人类遗传学方面有不同的背景。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Mental health and music engagement: review, framework, and guidelines for future studies.

• DOI: 10.1038/s41398-021-01483-8
• 发表时间: 2021-06-22
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Gustavson DE;Coleman PL;Iversen JR;Maes HH;Gordon RL;Lense MD
• 通讯作者: Lense MD

Linking the genomic signatures of human beat synchronization and learned song in birds

将人类节拍同步的基因组特征与鸟类学习的歌曲联系起来

• DOI: 10.1098/rstb.2020.0329
• 发表时间: 2021
• 期刊: Philosophical Transactions of the Royal Society B: Biological Sciences
• 作者: Gordon, Reyna L.;Ravignani, Andrea;Hyland Bruno, Julia;Robinson, Cristina M.;Scartozzi, Alyssa;Embalabala, Rebecca;Niarchou, Maria;Cox, Nancy J.;Creanza, Nicole
• 通讯作者: Creanza, Nicole

The Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) Framework for Understanding Musicality-Language Links Across the Lifespan.

• DOI: 10.1162/nol_a_00079
• 发表时间: 2022
• 期刊: NEUROBIOLOGY OF LANGUAGE
• 影响因子: 3.2
• 作者: Nayak, Srishti;Coleman, Peyton L.;Ladanyi, Eniko;Nitin, Rachana;Gustavson, Daniel E.;Fisher, Simon E.;Magne, Cyrille L.;Gordon, Reyna L.
• 通讯作者: Gordon, Reyna L.

A neurodevelopmental disorders perspective into music, social attention, and social bonding.

• DOI: 10.1017/s0140525x20001302
• 发表时间: 2021-09-30
• 期刊: BEHAVIORAL AND BRAIN SCIENCES
• 影响因子: 29.3
• 作者: Kasdan, Anna;Gordon, Reyna L.;Lense, Miriam D.
• 通讯作者: Lense, Miriam D.

Exploring the genetics of rhythmic perception and musical engagement in the Vanderbilt Online Musicality Study.

在范德比尔特在线音乐性研究中探索节奏感知和音乐参与的遗传学。

• DOI: 10.1111/nyas.14964
• 发表时间: 2023
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Gustavson,DanielE;Coleman,PeytonL;Wang,Youjia;Nitin,Rachana;Petty,LaurenE;Bush,CatherineT;Mosing,MiriamA;Wesseldijk,LauraW;Ullén,Fredrik;23andMeResearchTeam;Below,JenniferE;Cox,NancyJ;Gordon,ReynaL
• 通讯作者: Gordon,ReynaL