CONFERENCE: Protein Folding on the Ribosome; December 14-16, 2019; Berlin, Germany

2019年核糖体蛋白质折叠年会将于2019年12月16日至18日在德国柏林夏里特大学举行。在细胞背景下理解新生蛋白质的行为在理论上和实验上都提出了许多挑战。本次会议将汇集领先的专家介绍他们的最新研究，确定可以通过理论和实验相结合的努力来解决的关键问题和关键挑战。本次国际会议将由教师、博士后和研究生参加。预计这次会议将把处于不同职业阶段的美国科学家聚集在一起，讨论遗传学和分子生物物理学交叉领域的前沿成果，从而加强美国的科学。为参加本次国际会议的美国研究生和博士后提供旅费援助，将促进全球劳动力的培训，并通过与世界各地的科学家建立各种联系机会，支持他们的职业发展。在过去的几年中，已经出现了描述共翻译蛋白质折叠和其他共翻译过程的高影响力出版物。利用单分子技术，低温电镜，深度测序和各种其他方法的实验已经产生了丰富的数据，可以为理论和模拟提供信息，从而为新生蛋白质折叠的物理原理提供基本见解。同时，理论和模拟方法也正在发展，以模拟这种大型生物系统的长度和时间尺度。在这个关键时刻，在许多方面都取得了进展，重要的是将理论家和实验家聚集在一起，共同规划这两个群体如何共同推动新生的蛋白质折叠领域向前发展。本次会议将涵盖的主题包括：共翻译过程约束下的mRNA序列进化，共翻译蛋白质量控制系统，实验和理论探测的核糖体蛋白折叠，共翻译过程与翻译延伸动力学的耦合，新生蛋白成熟：伴侣，靶向和膜易位以及受蛋白质生物发生过程影响的下游过程。本次会议由分子和细胞生物科学部的分子生物物理学和遗传机制集群支持。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The 2019 Annual Meeting on Protein Folding on the Ribosome will be held at the Charite University of Berlin in Berlin, Germany on December 16-18, 2019. Understanding nascent protein behavior in the cellular context presents a host of challenges both theoretically and experimentally. This meeting will bring together leading experts to present their latest research, identify crucial questions and key challenges that could be addressed through a combined theoretical and experimental effort. This international meeting will be attended by faculty, postdocs and graduate students. It is expected that this meeting will strengthen US science by bringing together US-based scientists at different career stages to discuss cutting-edge results on an exciting area at the intersection of genetics and molecular biophysics. Travel assistance to US graduate students and postdocs to attend this international meeting will promote the training of a global workforce and support their career development through various networking opportunities with scientists around the world. The past several years has seen high impact publications describing co-translational protein folding and other co-translational processes have emerged. Experiments utilizing single molecule techniques, cryo-EM, deep sequencing and a variety of other methods have generated a wealth of data that can inform both theory and simulation and thereby provide fundamental insights into the physical principles of nascent protein folding. Concurrently, theory and simulation methods are also being developed to model the length and time scales of such large biological systems. At this crucial juncture, with advances being made on many fronts, it is important to bring together theoreticians and experimentalists to map out how these two communities can move the nascent protein folding field forward together. The topics this conference will cover include: mRNA sequence evolution under the constraints of co-translational processes, co-translational protein quality control system, protein folding on the ribosome probed experimentally and theoretically, the coupling of co-translational processes to translation-elongation kinetics, nascent protein maturation: chaperones, targeting and membrane translocation and downstream processes influenced by what happens during protein biogenesis. This meeting is supported by the Molecular Biophysics and the Genetic Mechanism Clusters of the Division of Molecular and Cellular Biosciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.