Reconstituting Biology – a Chart to Minimal Cells

重建生物学——最小细胞图表

• 批准号: 2013809
• 负责人: Allen Po-Chih Liu
• 金额: $ 2.62万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2023-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2013809&HistoricalAwards=false
• 关键词: Reconstituting; Biology; Chart; Minimal; Cells

The Lorentz Center workshop on Reconstituting Biology will be held in Leiden, The Netherlands at the end of June and early July 2020. The workshop, capped at 55 participants, focuses on discussing the current state-of-the-art and challenges in research centering on engineering minimal synthetic cells. Building upon recent consortiums formed in Germany and The Netherlands and large research teams formed in the US, the workshop will feature leaders working in this space from Europe and the US. The workshop is mostly discussion-based in small groups and will include trainees from the invited groups and some selected junior faculty. The workshop provides unique opportunities for the trainees and junior faculty to network with expert researchers in the field, potentially leading to new research ideas. The workshop will focus on four questions/goals: 1) Will we ever be able to reconstitute anything life-like? 2) Define the role of human-designed elements or building blocks play in building synthetic minimal cells. 3) What are currently the main limitations for reconstituting cellular functionalities from the bottom up and how do we overcome them? 4) Define approaches/practices to set up research community that shares building blocks, techniques, and protocols to ensure findings are reproducible across many labs. The workshop discussion will be collected by the workshop co-chairs along with input from the participants, with an aim to publish it as a perspective article to reach a large community. This award was co-funded by the Cellular Dynamics and Function Cluster and the Systems and Synthetic Biology Cluster in the Division of Molecular and Cellular Biosciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

洛伦兹中心重构生物学研讨会将于 2020 年 6 月底至 7 月初在荷兰莱顿举行。该研讨会的参与者上限为 55 人，重点讨论以工程最小合成细胞为中心的研究的当前最新技术和挑战。该研讨会以德国和荷兰最近成立的联盟以及美国成立的大型研究团队为基础，将邀请来自欧洲和美国的该领域的领导者参加。研讨会主要以小组讨论为主，包括受邀小组的学员和一些选定的初级教师。该研讨会为学员和初级教师提供了与该领域的专家研究人员建立联系的独特机会，有可能产生新的研究想法。研讨会将重点讨论四个问题/目标：1）我们是否能够重建任何栩栩如生的东西？ 2) 定义人类设计的元素或构建块在构建合成最小细胞中的作用。 3）目前自下而上重建细胞功能的主要限制是什么？我们如何克服它们？ 4) 定义建立研究社区的方法/实践，共享构建模块、技术和协议，以确保研究结果可以在许多实验室中重现。研讨会联合主席将收集研讨会的讨论内容以及参与者的意见，旨在将其作为观点文章发布，以覆盖更大的社区。该奖项由分子和细胞生物科学部的细胞动力学和功能集群以及系统和合成生物学集群共同资助。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。