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CAREER: Transport and collective behavior of microswimmers in porous media

职业：微型游泳者在多孔介质中的传输和集体行为

基本信息

批准号：
1941716
负责人：
Sujit Datta
金额：
$ 51.01万
依托单位：
Princeton University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1941716&HistoricalAwards=false
关键词：
CAREER Transport collective behavior microswimmers

项目摘要

This CAREER award will investigate how bacteria move in porous environments such as tissue, gels, soils, and sediment. Bacteria are examples of microswimmers, a class of particles that can propel themselves through fluid. The investigators will use 3D printing to fabricate porous environments with controlled pore structures, and they will use microscopy to observe how the bacteria move. These studies will reveal how the motion and self-organization of bacteria depend on the properties of their environment, the properties of the cells themselves, and interactions among the cells. The project will provide new research experiences and educational modules for high school, undergraduate, and graduate students, with a specific focus on students from under-represented groups. It will also enable new presentations and demonstrations to inspire and engage K-12 students at the Princeton Public Library and at local schools. Finally, it will provide opportunities for discussion forums, workshops, and dissemination of computational tools to the broader scientific community.This project will develop new experimental techniques and mathematical models to generate a fundamental understanding of microswimmer transport and collective behavior in porous media. The work will focus on bacteria, an archetype of microswimmers that can move through fluid by flagellar propulsion. Two fundamental questions will be addressed. First, how is single-cell motility altered by pore-scale confinement - specifically, how does motility depend on the properties of the cells and of the porous medium? Second, how do cell-cell interactions guide collective behavior in porous media? By connecting cellular properties, porous medium properties, and motility/collective behavior, this work will generate knowledge to enable prediction and control over bacterial transport and organization. Results from this project will help practitioners control bacterial behavior in applications such as treating infections, microbial drug delivery, using soil bacteria for agriculture, and bioremediation. More broadly, this work will provide a foundation for future studies of microswimmers in complex environments and will guide the design and use of synthetic microswimmers for applications ranging from drug delivery to chemical sensing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该职业奖将研究细菌如何在多孔环境中移动，如组织，凝胶，土壤和沉积物。细菌是微泳者的例子，微泳者是一类可以在流体中推进自己的粒子。研究人员将使用3D打印来制造具有受控孔结构的多孔环境，并将使用显微镜观察细菌如何移动。这些研究将揭示细菌的运动和自组织如何取决于其环境的特性，细胞本身的特性以及细胞之间的相互作用。该项目将为高中生、本科生和研究生提供新的研究经验和教育模块，特别关注代表性不足群体的学生。它还将使新的演示和演示能够激励和吸引普林斯顿公共图书馆和当地学校的K-12学生。最后，它将提供讨论论坛，研讨会和传播的计算工具，以更广泛的科学界的机会。该项目将开发新的实验技术和数学模型，以产生在多孔介质中的microswimmer运输和集体行为的基本理解。这项工作将集中在细菌上，这是一种微型游泳者的原型，可以通过鞭毛推进在流体中移动。将讨论两个基本问题。首先，单细胞的运动性是如何被孔尺度限制改变的--具体地说，运动性是如何依赖于细胞和多孔介质的性质的？第二，细胞间的相互作用如何引导多孔介质中的集体行为？通过连接细胞特性，多孔介质特性和运动/集体行为，这项工作将产生知识，使预测和控制细菌的运输和组织。该项目的结果将帮助从业者在治疗感染、微生物药物输送、利用土壤细菌进行农业和生物修复等应用中控制细菌行为。更广泛地说，这项工作将提供一个基础，为未来的研究在复杂的环境中的microswimmer，并将指导设计和使用的合成microswimmer的应用范围从药物输送到化学sensing.This奖项反映了NSF的法定使命，并已被认为是值得的支持，通过评估使用基金会的智力价值和更广泛的影响审查标准。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Impact of confined geometries on hopping and trapping of motile bacteria in porous media

受限几何形状对多孔介质中运动细菌跳跃和捕获的影响

DOI：
10.1103/physreve.103.012611
发表时间：
2021
期刊：
Physical Review E
影响因子：
2.4
作者：
Perez, Lazaro J.;Bhattacharjee, Tapomoy;Datta, Sujit S.;Parashar, Rishi;Sund, Nicole L.
通讯作者：
Sund, Nicole L.

Cellular Sensing Governs the Stability of Chemotactic Fronts