Optimization of polymer and lipid nanocarriers and nanocrystals/particles for dermal delivery (A01)

结合高载药量（>80%）和缓释性能的联合收割机纳米胶囊，将通过新的物理方法制备，作为基质型纳米颗粒的替代品。通过组合不同的纳米载体以及通过pH和皮脂触发的纳米载体，将实现药物释放的更大灵活性，所述pH和皮脂触发的纳米载体将在所需的pH阈值下释放药物，或者通过在患病皮肤中或毛囊内的皮脂中溶解/塑化来释放药物。此外，将研究纳米载体在掺入最终皮肤媒介物中后的性能以及它们在其中的直接制备和制备后、储存期间和皮肤施用后的重要纳米载体稳定性问题。

Nanocapsules, which combine both high drug loading (>80%) and extended release properties, will be prepared by novel physical methods as an alternative to matrix-type nanoparticles. More flexibility in drug release will be achieved by combining different nanocarriers and by pH- and sebum-triggered nanocarriers, which will release the drug at a desired pH-threshold or by dissolution/plasticization in sebum in diseased skin or within hair follicles. In addition, the performance of nanocarriers after incorporation in final dermal vehicles as well as their direct preparation therein and important nanocarrier stability issues after preparation, during storage and after skin administration will be investigated.