CAREER: Picoliter Nuclear Magnetic Resonance Spectroscopy with Diamond Quantum Sensors

职业：使用金刚石量子传感器进行皮升核磁共振波谱分析

• 批准号: 1945148
• 负责人: Victor Acosta
• 金额: $ 65万
• 依托单位: University of New Mexico
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1945148&HistoricalAwards=false
• 关键词: CAREER; Picoliter; Nuclear; Magnetic; Resonance

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, and co-funding from the Established Program to Stimulate Competitive Research (EPSCoR) and the Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), Professor Acosta and his group at the University of New Mexico are developing new measurement tools called “quantum sensors” to identify the molecular composition of samples with spatial resolution compatible with analysis of single cells. A quantum sensor uses a qubit (the logical element of a quantum computer) to detect its local environment. Specifically, Acosta’s lab uses defects in diamond, called Nitrogen-Vacancy centers, as the qubit sensors. The Acosta group is using these sensors to detect the oscillating magnetic fields naturally produced by chemical and biological samples via a technique that is analogous to medical magnetic resonance imaging (MRI). The information obtained by these methods is being used to identify the type and quantity of molecules in samples of a size comparable to individual cells. Prof. Acosta is working with a startup company to develop portable quantum sensor technology that can be used in undergraduate chemistry and physics teaching labs. His educational efforts also include designing the curriculum for a summer school that will introduce undergraduates from a diverse range of backgrounds to the field of quantum sensing.Professor Acosta is implementing a synergistic research and educational plan to develop a platform for small-volume nuclear magnetic resonance (NMR) spectroscopy which uses diamond quantum sensors to generate and detect nuclear magnetization. Specifically, he seeks to develop two different implementations of diamond NMR hardware: (i) a microfluidic platform suitable for parallel chemical analysis of picoliter analyte volumes and (ii) a hyperspectral NMR microscope for quantifying metabolic composition with single cell resolution. The research is based on the hypothesis a non-inductive detection modality (diamond quantum sensors) can lead to improvements in sensitivity, spectral resolution, spatial resolution, and microfluidic integration beyond what is currently available in small-volume NMR spectroscopy. Dr. Acosta is integrating diamond NMR into undergraduate teaching labs and assessing the learning outcomes. He is also designing a curriculum for a one-week summer or winter school in quantum engineering targeting undergraduates, with an emphasis on women, under-represented minorities, and first-generation college students. His aim is to attract a diverse student body into the physical/chemical sciences and specifically to quantum sensing and engineering.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量和成像项目的支持下，以及来自刺激竞争研究既定项目（EPSCoR）和化学、生物工程、环境和运输系统部门（CBET）的共同资助，阿科斯塔教授和他在新墨西哥大学的团队正在开发一种名为“量子传感器”的新型测量工具，以识别样品的分子组成，其空间分辨率与单细胞分析相兼容。量子传感器使用量子位（量子计算机的逻辑元素）来检测其本地环境。具体来说，阿科斯塔的实验室使用金刚石中的缺陷，称为氮空位中心，作为量子比特传感器。阿科斯塔研究小组正在使用这些传感器，通过一种类似于医学磁共振成像（MRI）的技术，检测化学和生物样品自然产生的振荡磁场。通过这些方法获得的信息被用于识别与单个细胞大小相当的样品中分子的类型和数量。阿科斯塔教授正在与一家初创公司合作，开发可用于本科化学和物理教学实验室的便携式量子传感器技术。他的教育工作还包括为一所暑期学校设计课程，该学校将向来自不同背景的本科生介绍量子传感领域。Acosta教授正在实施一项协同研究和教育计划，以开发一个小体积核磁共振（NMR）光谱平台，该平台使用钻石量子传感器来产生和检测核磁化。具体来说，他试图开发两种不同的金刚石核磁共振硬件实现：(i)适合于皮升分析物体积平行化学分析的微流控平台和（ii）用于单细胞分辨率定量代谢成分的高光谱核磁共振显微镜。该研究基于一种假设，即一种非感应检测方式（金刚石量子传感器）可以提高灵敏度、光谱分辨率、空间分辨率和微流体集成，而不是目前在小体积核磁共振光谱中可用的。阿科斯塔博士正在将钻石核磁共振整合到本科教学实验室，并评估学习成果。他还在为本科生设计为期一周的量子工程暑期或冬季学校课程，重点关注女性、少数族裔和第一代大学生。他的目标是吸引不同的学生群体进入物理/化学科学，特别是量子传感和工程领域。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Super-Resolution Diamond Magnetic Microscopy of Superparamagnetic Nanoparticles

• DOI: 10.1021/acsnano.3c12283
• 发表时间: 2024-02-19
• 期刊: ACS NANO
• 影响因子: 17.1
• 作者: Mosavian，Nazanin;Hubert，Forrest;Acosta，Victor M.
• 通讯作者: Acosta，Victor M.

Temperature Sensitivity of 14N-V and 15N-V Ground-State Manifolds

14N-V 和 15N-V 基态流形的温度灵敏度

• DOI: 10.1103/physrevapplied.19.064084
• 发表时间: 2023
• 期刊: Physical Review Applied
• 影响因子: 4.6
• 作者: Lourette, Sean;Jarmola, Andrey;Acosta, Victor M.;Birdwell, A. Glen;Budker, Dmitry;Doherty, Marcus W.;Ivanov, Tony;Malinovsky, Vladimir S.
• 通讯作者: Malinovsky, Vladimir S.

Proposal for the search for new spin interactions at the micrometer scale using diamond quantum sensors

• DOI: 10.1103/physrevresearch.4.023162
• 发表时间: 2021-12
• 期刊: Physical Review Research
• 影响因子: 4.2
• 作者: P. Chu;N. Ristoff;J. Smits;N. Jackson;Y. J. Kim;I. Savukov;V. Acosta