Reductive Radical Cyclizations for Heterocycle Synthesis
杂环合成的还原自由基环化
基本信息
- 批准号:240508776
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2013
- 资助国家:德国
- 起止时间:2012-12-31 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The development of modern and efficient methods for the synthesis of heterocyclic building blocks is of fundamental importance for the synthesis of natural products and drugs as well as industrial applications. The titanium(III)-catalyzed radical cyclizations that will be developed in this project will enable unconventional, flexible, and straightforward syntheses of central indole, pyrrole, indolizidine, and quinolizidine building blocks, as well as multifunctionalized pyridines. In addition, structural fragments such as 3-aminoindoles and 3-pyrroles will become directly available and can be derivatized in situ. Previously, these molecule classes were rarely employed in organic synthesis due to their instability and limited synthetic access. The applicability of the presented innovative cyclization methods will be demonstrated on highly efficient total syntheses of natural products such as isatisin A, mitragynin and mitragynin pseudoindoxyl. The successful completion of this project will further establish the titanium(III)-catalysis as a versatile method for heterocycle synthesis.
发展现代高效的杂环合成方法对天然产物和药物的合成以及工业应用具有重要意义。本项目将开发的钛(III)催化的自由基环化将使中心吲哚、吡咯、吲哚吡啶和喹啉吡啶的构建块以及多功能化吡啶的合成成为可能,这是非常规的、灵活的和直接的。此外,3-氨基吲哚和3-吡咯等结构片段将直接可用,并可原位衍生。以前,由于这些分子类的不稳定性和合成途径有限,很少用于有机合成。所提出的创新环化方法的适用性将在天然产物如板蓝藻素A、米特ragynin和米特ragynin pseudoindoxyl的高效全合成中得到证明。该项目的成功完成将进一步确立钛(III)催化合成杂环的多用途方法。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Jan Streuff其他文献
Professor Dr. Jan Streuff的其他文献
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{{ truncateString('Professor Dr. Jan Streuff', 18)}}的其他基金
Transition-metal catalysed reductive bond-forming and bond-cleavage reactions
过渡金属催化的还原成键和断键反应
- 批准号:
408295365 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Heisenberg Grants
Dinuclear and ansa-titanocenes for enantioselective catalyst-controlled radical reactions and further applications
用于对映选择性催化剂控制的自由基反应的双核和柄型二茂钛及其进一步应用
- 批准号:
333382543 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Research Grants
Revealing the mechanisms of titanium-catalyzed umpolung reactions by a combined experimental and theoretical approach
通过实验和理论相结合的方法揭示钛催化反极化反应的机理
- 批准号:
275167197 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Research Grants
Reductive umpolung reactions with low-valent titanium catalysts: From the development, application and mechanistic understanding to a new concept for photoreduction catalysis
低价钛催化剂的还原反极性反应:从开发、应用和机理理解到光还原催化的新概念
- 批准号:
275166688 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Heisenberg Fellowships
Neuartige Titan(III)-katalysierte Redoxumpolungsreaktionen
新型钛(III)催化氧化还原极化反应
- 批准号:
213717717 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Research Grants
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