MCA-PGR: Cycling below-ground: Circadian regulation in wild and domesticated potato

MCA-PGR：地下循环：野生和驯化马铃薯的昼夜节律调节

• 批准号: 1950376
• 负责人: Eva Farre
• 金额: $ 220.65万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950376&HistoricalAwards=false
• 关键词: MCA; PGR; Cycling; below; ground

The circadian clock allows organisms to adjust their physiology to daily light/dark cycles. In humans, jet lag and poor health associated with shift work are due to the desynchronization of our body's circadian clock with the current environmental cycle. In plants, the circadian clock regulates a wide array of processes ranging from photosynthesis to stress responses. Moreover, the circadian clock enables plants to measure day length, and therefore, anticipate seasonal changes, which vary depending on the latitude. With changes in global climate, growth of crops at more northern and cooler latitudes will require adaptation to altered daylengths. Circadian clocks generate oscillations with a period of about, but not exactly, 24h. Natural variation in this endogenous circadian period has been measured in animals, including humans, and plants. Potato displays natural variation of circadian period and changes in this period have been linked by the PI’s to the process of potato domestication. The project supported by this award will investigate the role of the circadian period in the optimization of potato growth under different daylengths. Moreover, this project will also impact future generations of science teachers. School teachers are at the frontline of improving public scientific literacy and this project will not only train pre-service science educators on science practices and science teaching but also investigate the role research experiences in teacher training.The broad objective of this project is to understand how circadian rhythms contribute to the development of heterotrophic organs and adaptation to different photoperiods using potato as a model. This work will define the circadian and photoperiod regulatory gene networks in potato and their association with physiological traits; identify loci involved in circadian rhythm variation using a diversity panel of wild potato species that spans geographic diversity; and employ functional genomics approaches to characterize the role of circadian clock-associated loci in potato growth and development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物钟允许生物体根据每天的光/暗周期来调整他们的生理。在人类中，与倒班工作相关的时差和健康状况不佳是由于我们身体的生物钟与当前环境周期不同步造成的。在植物中，生物钟调节从光合作用到胁迫反应的一系列广泛的过程。此外，生物钟使植物能够测量白天的长度，从而预测季节变化，这种变化取决于纬度。随着全球气候的变化，作物在更北部和更凉爽的纬度生长将需要适应改变的日长。生物钟产生的振荡周期约为24小时，但不完全是24小时。在包括人类和植物在内的动物身上，已经测量到了这种内源性昼夜节律的自然变化。马铃薯表现出自然的昼夜节律变化，这一周期的变化与马铃薯的驯化过程有关。该奖项支持的项目将调查昼夜节律在不同日长下马铃薯生长优化中的作用。此外，该项目还将影响未来几代科学教师。学校教师处于提高公众科学素养的第一线，该项目不仅将培训任职前的科学教育工作者关于科学实践和科学教学，还将调查教师培训中的角色研究经验。该项目的广泛目标是以马铃薯为模型，了解昼夜节律如何有助于异养器官的发育和对不同光周期的适应。这项工作将定义马铃薯的昼夜节律和光周期调控基因网络及其与生理特性的关联；使用跨越地理多样性的野生马铃薯物种多样性小组来识别与昼夜节律变化有关的基因座；并使用功能基因组学方法来表征与昼夜节律相关的基因座在马铃薯生长和发育中的作用。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。